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Stroop task among patients with obsessive-compulsive disorder (OCD) and pathological gambling (PG) in methadone maintenance treatment (MMT)

Published online by Cambridge University Press:  23 December 2013

Einat Peles ,
Aviv Weinstein ,
Anat Sason ,
Miriam Adelson  and
Shaul Schreiber
Einat Peles*
Affiliation:
Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse Treatment and Research, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel (affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel)
Aviv Weinstein
Affiliation:
Department of Nuclear Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Anat Sason
Affiliation:
Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse Treatment and Research, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel (affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel)
Miriam Adelson
Affiliation:
Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse Treatment and Research, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel (affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel)
Shaul Schreiber
Affiliation:
Dr. Miriam and Sheldon G. Adelson Clinic for Drug Abuse Treatment and Research, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel (affiliated with the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel)
*
Address for correspondence: Einat Peles, PhD, Adelson Clinic for Drug Abuse, Treatment & Research, Tel-Aviv Sourasky Medical Center, 1 Henrietta Szold Street, Tel Aviv 64924, Israel. (Email: [email protected])
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Abstract

Objectives

To evaluate the impaired attention selection (Stroop interference effect) and general performance [reaction times (RTs)] on the Stroop task among methadone maintenance treatment (MMT) patients with obsessive compulsive disorder (OCD), pathological gambling (PG), both PG/OCD or none, and the influence if having ADHD.

Methods

Eighty-six patients and 15 control subjects underwent the Stroop task, which measured RTs of condition-related words (color, obsessive compulsive disorder, pathological gambling, addiction) and neutral words.

Results

MMT patients had longer RTs on the Stroop task compared with controls. RTs were longer among patients with OCD and in those who abused drugs on the study day. The combined PG/OCD group had the longest RTs, but they were also characterized as abusing more drugs, being older, and having worse cognitive status. Stroop color interference differed only among MMT patients with ADHD, and it was higher among those with OCD than those without OCD. The modified condition-related Stroop did not show any interference effect of OCD, addiction, or gambling words.

Conclusions

MMT patients had generally poorer performance, as indicated by longer RTs, that were related to clinical OCD, drug abuse, poor cognitive state, and older age. Patients with both clinical OCD and ADHD had a higher Stroop interference effect, which is a reflection of an attention deficit. In order to improve clinical approach and treatment of MMT patients, OCD and ADHD should be evaluated (and treated as needed).

Keywords

Attention deficit hyperactivity disordermethadone maintenance treatmentobsessive compulsive disorderpathological gamblingStroop interference
Type
Original Research
Information
CNS Spectrums , Volume 19 , Issue 6 , December 2014 , pp. 509 - 518
Copyright
Copyright © Cambridge University Press 2013 

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Footnotes

Drs. Schreiber and Adelson contributed equally to the study and the manuscript preparation.

We thank Esther Eshkol for English editing and Erez Peles for the stroop programming.

References

1.Navaratnam, V, Foong, K. Sequence of onset of different drug use among opiate addicts. Curr Med Res Opin. 1989; 11(9): 600–609.Google Scholar
2.Assanangkornchai, S, Edwards, JG. Clinical and epidemiological assessment of substance misuse and psychiatric comorbidity. Curr Opin Psychiatry. 2012; 25(3): 187–193.Google Scholar
3.Bracken, BK, Trksak, GH, Penetar, DM, etal. Response inhibition and psychomotor speed during methadone maintenance: impact of treatment duration, dose, and sleep deprivation. Drug Alcohol Depend. 2012; 125(1–2): 132–139.CrossRefGoogle ScholarPubMed
4.Lin, WC, Chou, KH, Chen, HL, etal. Structural deficits in the emotion circuit and cerebellum are associated with depression, anxiety and cognitive dysfunction in methadone maintenance patients: a voxel-based morphometric study. Psychiatry Res. 2012; 201(2): 89–97.CrossRefGoogle ScholarPubMed
5.Marvel, CL, Faulkner, ML, Strain, EC, etal. An fMRI investigation of cerebellar function during verbal working memory in methadone maintenance patients. Cerebellum. 2012; 11(1): 300–310.Google Scholar
6.Soyka, M, Zingg, C, Koller, G, etal. Cognitive function in short- and long-term substitution treatment: are there differences? World J Biol Psychiatry. 2010; 11(2): 400–408.Google Scholar
7.Gruber, SA, Tzilos, GK, Silveri, MM, etal. Methadone maintenance improves cognitive performance after two months of treatment. Exp Clin Psychopharmacol. 2006; 14(2): 157–164.Google Scholar
8.Kollins, SH. A qualitative review of issues arising in the use of psycho-stimulant medications in patients with ADHD and co-morbid substance use disorders. Curr Med Res Opin. 2008; 24(5): 1345–1357.Google Scholar
9.Schubiner, H. Substance abuse in patients with attention-deficit hyperactivity disorder: therapeutic implications. CNS Drugs. 2005; 19(8): 643–655.Google Scholar
10.Wilens, TE. Impact of ADHD and its treatment on substance abuse in adults. J Clin Psychiatry. 2004; 65(3): 38–45.Google Scholar
11.Dopheide, JA, Pliszka, SR. Attention-deficit-hyperactivity disorder: an update. Pharmacotherapy. 2009; 29(6): 656–679.Google Scholar
12.Barkley, RA, Cox, D. A review of driving risks and impairments associated with attention-deficit/hyperactivity disorder and the effects of stimulant medication on driving performance. J Safety Res. 2007; 38(1): 113–128.Google Scholar
13.Minkoff, NB. ADHD in managed care: an assessment of the burden of illness and proposed initiatives to improve outcomes. Am J Manag Care. 2009; 15(5): S151–159.Google ScholarPubMed
14.Prosser, J, Cohen, LJ, Steinfeld, M, etal. Neuropsychological functioning in opiate-dependent subjects receiving and following methadone maintenance treatment. Drug Alcohol Depend. 2006; 84(3): 240–247.Google Scholar
15.Mintzer, MZ, Stitzer, ML. Cognitive impairment in methadone maintenance patients. Drug Alcohol Depend. 2002; 67(1): 41–51.Google Scholar
16.Perret, E. The left frontal lobe of man and the suppression of habitual responses in verbal categorical behavior. Neuropsychology. 1974; 12(3): 323–330.Google Scholar
17.Peterson, BS, Skudlarski, P, Gatenby, JC, etal. An fMRI study of Stroop word-color interference: evidence for cingulate subregions subserving multiple distributed attentional systems. Biol Psychiatry. 1999; 45(10): 1237–1258.Google Scholar
18.Peles, E, Adelson, M, Schreiber, S. Association of OCD with a history of traumatic events among patients in methadone maintenance treatment. CNS Spectr. 2009; 14(10): 547–554.Google Scholar
19.Peles, E, Schreiber, S, Adelson, M. Pathological gambling and obsessive compulsive disorder among methadone maintenance treatment patients. J Addict Dis. 2009; 28(3): 199–207.Google Scholar
20.Peles, E, Schreiber, S, Adelson, M. 15-Year survival and retention of patients in a general hospital-affiliated methadone maintenance treatment (MMT) center in Israel. Drug Alcohol Depend. 2010; 107(2–3): 141–148.Google Scholar
21.Hartston, HJ, Swerdlow, NR. Visuospatial priming and Stroop performance in patients with obsessive–compulsive disorder. Neuropsychology. 1999; 13(3): 447–455.Google Scholar
22.Galderisi, S, Mucci, A, Catapano, F, etal. Neuropsychological slowness in obsessive–compulsive patients: is it confined to tests involving the fronto-subcortical systems? Br J Psychiatry. 1995; 167(3): 394–398.Google Scholar
23.Purcell, R, Maruff, P, Kyrios, M, etal. Neuropsychological deficits in obsessive–compulsive disorder: a comparison with unipolar depression, panic disorder, and normal controls. Arch Gen Psychiatry. 1998; 55(5): 415–423.Google Scholar
24.Schlösser, RG, Wagner, G, Schachtzabel, C, etal. Fronto-cingulate effective connectivity in obsessive compulsive disorder: a study with fMRI and dynamic causal modeling. Hum Brain Mapp. 2010; 31(12): 1834–1850.Google Scholar
25.Abramovitch, A, Dar, R, Schweiger, A, etal. Neuropsychological impairments and their association with obsessive-compulsive symptom severity in obsessive-compulsive disorder. Arch Clin Neuropsychol. 2011; 26(4): 364–376.Google Scholar
26.Kertzman, S, Lowengrub, K, Aizer, A, etal. Stroop performance in pathological gamblers. Psychiatry Res. 2006; 142(1): 1–10.Google Scholar
27.Potenza, MN, Leung, HC, Blumberg, HP, etal. An FMRI Stroop task study of ventromedial prefrontal cortical function in pathological gamblers. Am J Psychiatry. 2003; 160(11): 1990–1994.Google Scholar
28.Peles, E, Schreiber, S, Sutzman, A, etal. Attention deficit hyperactivity disorder and obsessive-compulsive disorder among former heroin addicts currently in methadone maintenance treatment. Psychopathology. 2012; 45(5): 327–333.Google Scholar
29.Weinstein, A, Cox, WM. Cognitive processing of drug-related stimuli: the role of memory and attention. J Psychopharmacol. 2006; 20(6): 850–859.Google Scholar
30.Adelson, MO, Hayward, R, Bodner, G, etal. Replication of an effective opiate addiction pharmacotherapeutic treatment model: minimal need for modification in a different country. Journal of Maintenance in the Addictions. 2000; 1(4): 5–13.Google Scholar
31.Kessler, RC, Adler, L, Ames, M, etal. The World Health Organization Adult ADHD Self-Report Scale (ASRS): a short screening scale for use in the general population. Psychol Med. 2005; 35(2): 245–256.Google Scholar
32.Adler, LA, Spencer, T, Faraone, SV, etal. Validity of pilot Adult ADHD Self-Report Scale (ASRS) to rate adult ADHD symptoms. Ann Clin Psychiatry. 2006; 18(3): 145–148.Google Scholar
33.Ward, MF, Wender, PH, Reimherr, FW. The Wender Utah Rating Scale: an aid in the retrospective diagnosis of childhood attention deficit hyperactivity disorder. Am J Psychiatry. 1993; 150(8): 885–890.Google Scholar
34.Folstein, MF, Folstein, SE, McHugh, PR. “Mini-mental state”: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3): 189–198.Google Scholar
35.Lesieur, HR, Blume, SB. The South Oaks Gambling Screen (SOGS): a new instrument for the identification of pathological gamblers. Am J Psychiatry. 1987; 144(9): 1184–1188.Google Scholar
36.Goodman, WK, Price, LH, Rasmussen, SA, etal. The Yale-Brown Obsessive Compulsive Scale. I. Development, use, and reliability. Arch Gen Psychiatry. 1989; 46(11): 1006–1011.Google Scholar
37.McLellan, AT, Luborsky, L, O'Brien, CP, etal. The Addiction Severity Index in three different populations. NIDA Res Monogr. 1984; 55: 217–223.Google Scholar
38.Hawks, RL. Analytical methodology. NIDA Res Monogr. 1986; 73: 30–42.Google Scholar
39.Lusher, J, Chandler, C, Ball, D. Alcohol dependence and the alcohol Stroop paradigm: evidence and issues. Drug Alcohol Depend. 2004; 75(3): 225–231.Google Scholar
40.Moritz, S, Fischer, BK, Hottenrott, B, etal. Words may not be enough! No increased emotional Stroop effect in obsessive-compulsive disorder. Behav Res Ther. 2008; 46(9): 1101–1104.Google Scholar
41.Peles, E, Schreiber, S, Linzy, S, etal. Pathological gambling in methadone maintenance clinics where gambling is legal versus illegal. Am J Orthopsychiatry. 2010; 80(3): 311–316.CrossRefGoogle ScholarPubMed
42.Barkley, RA. ADHD and the Nature of Self-Control. New York: Guilford Press; 1997.Google Scholar
43.Lansbergen, MM, Kenemans, JL, van Engeland, H. Stroop interference and attention-deficit/hyperactivity disorder: a review and meta-analysis. Neuropsychology. 2007; 21(2): 251–262.Google Scholar
44.Verdejo, A, Toribio, I, Orozco, C, etal. Neuropsychological functioning in methadone maintenance patients versus abstinent heroin abusers. Drug Alcohol Depend. 2005; 78(3): 283–288.Google Scholar
45.Fadardi, JS, Ziaee, SS. A comparative study of drug-related attentional bias: evidence from Iran. Exp Clin Psychopharmacol. 2010; 18(6): 539–545.Google Scholar
46.Specka, M, Finkbeiner, T, Lodemann, E, etal. Cognitive-motor performance of methadone-maintained patients. Eur Addict Res. 2000; 6(1): 8–19.Google Scholar
47.Curran, HV. Psychopharmacological approaches to human memory. In: Gazzaniga MS, ed. The Cognitive Neurosciences, 2nd ed.Boston: MIT Press; 2000: 797–804.Google Scholar