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Serum levels of brain-derived neurotrophic factor (BDNF), BDNF gene Val66Met polymorphism, or plasma catecholamine metabolites, and response to mirtazapine in Japanese patients with major depressive disorder (MDD)

Published online by Cambridge University Press:  10 August 2012

Asuka Katsuki ,
Reiji Yoshimura ,
Taro Kishi ,
Hikaru Hori ,
Wakako Umene-Nakano ,
Atsuko Ikenouchi-Sugita ,
Kenji Hayashi ,
Kiyokazu Atake ,
Nakao Iwata  and
Jun Nakamura
Asuka Katsuki
Affiliation:
Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan
Reiji Yoshimura*
Affiliation:
Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan
Taro Kishi
Affiliation:
Department of Psychiatry, Zucker Hillside Hospital, Glen Oaks, New York, USA Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
Hikaru Hori
Affiliation:
Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan
Wakako Umene-Nakano
Affiliation:
Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan
Atsuko Ikenouchi-Sugita
Affiliation:
Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan
Kenji Hayashi
Affiliation:
Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan
Kiyokazu Atake
Affiliation:
Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan
Nakao Iwata
Affiliation:
Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan
Jun Nakamura
Affiliation:
Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan
*
*Address for correspondence: Reiji Yoshimura, Department of Psychiatry, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kiyakyushu 8078555, Japan. (Email [email protected])
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Abstract

Object

We investigated an association between the polymorphism of brain-derived neurotrophic factor (BDNF) gene Val66Met and the response to mirtazapine in Japanese patients with major depressive disorder (MDD). We also examined mirtazapine's effects on the serum BDNF and plasma levels of catecholamine metabolites in these patients.

Methods

Eighty-four patients who met the DSM-IV-TR criteria for MDD were treated with only mirtazapine for 4 weeks. The BDNF Val66Met polymorphism was detected by direct sequencing in the region, and serum BDNF levels and plasma levels of catecholamine metabolites were measured by ELISA and HPLC-ECD, respectively.

Results

Mirtazapine treatment for 4 weeks significantly increased serum BDNF levels in the responders, whereas nonresponders showed significant decreases. No association was found between either of the two genotypes (Val/Val vs. Met-carriers) and the response to mirtazapine at T4 or the serum BDNF levels at T0. Mirtazapine did not alter the plasma levels of homovanillic acid (HVA) or 3-methoxy-4-hydroxyphenylglycol (MHPG).

Discussion

The dynamics of serum BDNF levels, but not plasma levels of HVA and MHPG, reflect the response to mirtazapine treatment; the BDNF Val66Met polymorphism in patients with depression is, however, associated with neither a particular response to mirtazapine treatment nor baseline serum BDNF levels.

Conclusion

Serum BDNF levels, but not plasma levels of HVA or MHPG, and BDNF Val66Met polymorphism are related to the mirtazapine response in MDD.

Keywords

brain-derived neurotrophic factormirtazapine3-methoxy-4-hydroxyphenylglycolhomovanillic acidmajor depressive disorder
Type
Original Research
Information
CNS Spectrums , Volume 17 , Issue 3 , September 2012 , pp. 155 - 163
Copyright
Copyright © Cambridge University Press 2012

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Footnotes

We thank Ms. Kazuko Shimizu for her great help in sampling. This study was supported by a Health and Labour Science Research grants from the Japanese government.

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