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The role of the metabotropic glutamate receptor 5 in nicotine addiction

Published online by Cambridge University Press:  27 July 2020

Funda Akkus ,
Sylvia Terbeck ,
Connor J. Haggarty Open the ORCID record for Connor J. Haggarty [Opens in a new window] ,
Valerie Treyer ,
Janan J. Dietrich ,
Stefanie Hornschuh  and
Gregor Hasler Open the ORCID record for Gregor Hasler [Opens in a new window]
Funda Akkus*
Affiliation:
Department of Psychiatry, University of Fribourg, Fribourg, Switzerland Psychiatrie St. Gallen Nord, Wil, Switzerland
Sylvia Terbeck
Affiliation:
School of Psychology, Liverpool John Moores University, LiverpoolUnited Kingdom
Connor J. Haggarty
Affiliation:
School of Psychology, Liverpool John Moores University, LiverpoolUnited Kingdom
Valerie Treyer
Affiliation:
Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
Janan J. Dietrich
Affiliation:
Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Stefanie Hornschuh
Affiliation:
Perinatal HIV Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
Gregor Hasler
Affiliation:
Department of Psychiatry, University of Fribourg, Fribourg, Switzerland
*
*Author for correspondence: Funda Akkus, Email: [email protected]
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Abstract

This review summarizes the evidence for the potential involvement of metabotropic glutamate receptor 5 (mGluR5) in the development of nicotine addiction. Nicotine is consumed worldwide and is highly addictive. Previous research has extensively investigated the role of dopamine in association with reward learning and addiction, which has provided strong evidence for the involvement of dopaminergic neuronal circuitry in nicotine addiction. More recently, researchers focused on glutamatergic transmission after nicotine abuse, and its involvement in the reinforcing and rewarding effects of nicotine addiction. A number of robust preclinical and clinical studies have shown mGluR5 signaling as a facilitating mechanism of nicotine addiction and nicotine withdrawal. Specifically, clinical studies have illustrated lower cortical mGluR5 density in smokers compared to nonsmokers in the human brain. In addition, mGluR5 might selectively regulate craving and withdrawal. This suggests that mGluR5 could be a key receptor in the development of nicotine addiction and therefore clinical trials to examine the therapeutic potential of mGluR5 agents could help to contribute to reduce nicotine addiction in society.

Keywords

NicotineaddictionrelapsemGluR5
Type
Review
Information
CNS Spectrums , Volume 26 , Issue 6: Special Issue: Functional Neurological Disorder , December 2021 , pp. 601 - 606
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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