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Relationship Between Residual Symptoms of Depression and Self-reported Cognitive Impairment

Published online by Cambridge University Press:  07 November 2014

Paola Pedrelli ,
Lee Baer ,
Dan V. Iosifescu  and
Maurizio Fava
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Abstract

Objective: The present study aimed to investigate the associations between residual symptoms of depression and specific self-reported symptoms in several cognitive domains.

Methods: The study investigated 117 patients with partially or fully remitted major depressive disorder (MDD) after treatment with antidepressant medications.

Results: Fatigue was significantly associated with inability to focus, alertness, and feeling “blue”; low interest and difficulty with concentration were associated with apathy. No associations were found between deficits in the cognitive domains considered and residual symptoms such as self-blaming, feeling worthless, feeling hopeless, having suicidal thoughts, difficulty with sleep, and lack of appetite.

Conclusion: Among MDD remitted patients endorsing residual symptoms such as fatigue and feeling “blue”, deficits in a range of cognitive domains should be carefully assessed and treated.

Type
Original Research
Information
CNS Spectrums , Volume 15 , Issue 1 , January 2010 , pp. 46 - 51
Copyright
Copyright © Cambridge University Press 2010

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