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Neuroimaging in Temporal Lobe Epilepsy

Published online by Cambridge University Press:  07 November 2014

Gerard J. Muro  and
John P. Karis
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Abstract

Various neuroimaging modalities are available for evaluating patients with temporal lobe epilepsy (TLE). All patients considering surgery should undergo magnetic resonance imaging, which is valuable in the detection and characterization of lesions, particularly mesial temporal sclerosis, the most common abnormality in TLE. A localized seizure focus is predictive of successful surgical outcome. Complimentary neuroimaging studies include positron emission tomography, single-photon emission tomography, and proton magnetic resonance spectroscopy.

Type
Feature Articles
Information
CNS Spectrums , Volume 2 , Issue 7: Imitators of Epilepsy: Treatment Options , August 1997 , pp. 31 - 42
Copyright
Copyright © Cambridge University Press 1997

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References

1.Mullan, BP, O'Connor, MK, Hung, JC. Single photon emission computed tomography. Neuroimaging Clin N Am. 1995;5:647–673.Google ScholarPubMed
2.Hauser, WA, Annegers, JF, Kurland, LT. Incidence of epilepsy and unprovoked seizures in Rochester, Minnesota: 1935–1984. Epilepsia. 1993;34:453–468.CrossRefGoogle ScholarPubMed
3.Margerison, JH, Corsellis, JA. Epilepsy and the temporal lobes. A clinical, electroencephalographic study of the brain in epilepsy, with particular reference to the temporal lobes. Brain. 1966;89:499–530.CrossRefGoogle Scholar
4.Tien, RD, Felsberg, GJ, Campi de Castro, C. Complex partial seizures and mesial temporal sclerosis: evaluation with fast spin-echo MR imaging. Radiology. 1993;189:835–842.CrossRefGoogle ScholarPubMed
5.Swartz, BE, Tomiyasu, U, Delgado-Escueta, AV, et al.Neuroimaging in temporal lobe epilepsy: test sensitivity and relationships to pathology and postoperative outcome. Epilepsia. 1992;33:624–634.CrossRefGoogle ScholarPubMed
6.Duvernoy, HM. The Human Hippocampus. An Atlas of Applied Anatomy. Munchen: JF Bergmann Verlag, 1988. (enclosed).Google Scholar
7.Gray, H. Gray's Anatomy. 37th ed. New York, NY: Churchill Livingstone; 1989:1034–1039.Google Scholar
8.Cendes, F, Anderman, F, Gloor, P, et al.MRI volumetric measurement of amygdala and hippocampus in temporal lobe epilepsy. Neurology. 1993;43:719–725.CrossRefGoogle ScholarPubMed
9.Ettinger, AB. Structural causes of epilepsy: tumors, cysts, stroke, and vascular malformations. Neurol Clin. 1994;12:41–55.CrossRefGoogle ScholarPubMed
10.Cascino, CD, Kelly, PJ, Sharbrough, FW, et al.Long-term follow-up of stereotactic lesionectomy in partial epilepsy: predictive factors and electroencephalographic results. Epilepsia. 1992;33:639–644.CrossRefGoogle ScholarPubMed
11.Berkovic, SF, McIntosh, AM, Kalnins, RM, et al.Preoperative MRI predicts outcome of temporal lobectomy: an actuarial analysis. Neurology. 1995;45:1358–1363.CrossRefGoogle ScholarPubMed
12.Raymond, AA, Fish, DR, Sisodiya, M, et al.Abnormalities of gyration, heterotopias, tuberous sclerosis, focal cortical dysplasia, microdysgenesis, dysembryoplastic neuroepithelial tumour and dysgenesis of the archicortex in epilepsy. Clinical, EEC and neuroimaging features in 100 adult patients. Brain. 1995;118:629–660.CrossRefGoogle Scholar
13.Barkovich, AJ, Koch, TK, Carrol, CL. The spectrum of lissencephaly: report of ten patients analyzed by magnetic resonance imaging. Ann Neurol. 1991;30:139–146.CrossRefGoogle ScholarPubMed
14.Otsubo, H, Hwang, PA, Jay, V, et al.Focal cortical dysplasia in children with localization-related epilepsy: EEC, MRI, and SPECT findings. Pediatr Neurol. 1993;9:101–107.CrossRefGoogle Scholar
15.Jack, CR, Mullan, BP, Sharbrough, FW, et al.Intractable nonlesional epilepsy of temporal lobe origin: lateralization by interictal SPECT versus MRI. Neurology. 1994;44:829–836.CrossRefGoogle ScholarPubMed
16.Palmini, A, Andermann, F, Olivier, A. Focal neuronal migration disorders and intractable partial epilepsy: a study of 30 patients. Ann Neurol. 1991;30:741–949.CrossRefGoogle ScholarPubMed
17.Barkovich, AJ, Gressens, P, Evrard, P. Formation, maturation, and disorders of brain neocortex. Am J Neuro Radiol. 1992;13:423–446.Google ScholarPubMed
18.Barkovich, AJ, Kjos, BO. Gray matter heterotopias: MR characteristics and correlation with developmental and neurologic manifestations. Radiology. 1992;182:493–499.CrossRefGoogle ScholarPubMed
19.Kuzniecky, R, Murro, A, King, D, et al.Magnetic resonance imaging in childhood intractable partial epilepsies: pathologic correlations. Neurology. 1993;43:681–687.CrossRefGoogle ScholarPubMed
20.Lehéricy, S, Dormont, D, Sémah, F, et al.Developmental abnormalities of the medial temporal lobe in patients with temporal lobe epilepsy. Am J Neuro Radiol. 1995;16:617–626.Google ScholarPubMed
21.Kraemer, DL, Awad, IA. Vascular malformations and epilepsy: clinical considerations and basic mechanisms. Epilepsia. 1994;35(suppl 6):30–43.CrossRefGoogle ScholarPubMed
22.Requena, I, Arias, M, López-Ibior, L, Pereiro, I, et al.Cavernomas of the central nervous system: clinical and neuroimaging manifestations in 47 patients. J Neurol Neurosurg Psychiatry. 1991;54:590–594.CrossRefGoogle ScholarPubMed
23.Robinson, JR, Awad, IA, Little, JR. Natural history of the cavernous angioma. J Neurosurg. 1991;75:709–714.CrossRefGoogle ScholarPubMed
24.Forster, DMC, Steiner L, Häkanson. Arteriovenous malformations of the brain: a long-term clinical study. J Neurosurg. 1972;37:562–570.CrossRefGoogle ScholarPubMed
25.Ondra, SL, Troupp, H, George, ED, et al.The natural history of symptomatic arteriovenous malformation of the brain: a 24-year follow-up assessment. J Neurosurg. 1990;73:387–391.CrossRefGoogle Scholar
26.Gomori, JM, Grossman, RI, Gobberg, HI. et al.Occult cerebral vascular malformations: high field MR imaging. Radiology. 1986;158:707–713.CrossRefGoogle ScholarPubMed
27.Lühdorf, K, Jensen, LK, Plesner, AM. Etiology of seizures in the elderly. Epilepsia. 1986;27:458–463.CrossRefGoogle ScholarPubMed
28.Morris, HM, Estes, ML, Gilmore, R, et al.Chronic intractable epilepsy as the only symptom of primary brain tumor. Epilepsia. 1993;34:1038–1043.CrossRefGoogle ScholarPubMed
29.Zentner, J, Wolf, HK, Ostertun, B, et al.Gangliogliomas: clinical, radiological, and histopathological findings in 51 patients. J Neurol Neurosurg Psychiatary. 1994;57:1497–1502.CrossRefGoogle ScholarPubMed
30.Krouwer, HGJ, Davis, RL, McDermott, MW, et al.Gangliogliomas: a clinicopathological study of 25 cases and review of the literature. J Neurooncol. 1993;17:139–154.CrossRefGoogle ScholarPubMed
31.Koeller, KK, Dillon, WP. Dysembryoplastic neuroepithelial tumors: MR appearance. Am J Neuro Radiol. 1992;13:1319–1325.Google ScholarPubMed
32.Daumas-Duport, C, Scheithauer, BW, Chodkiewicz, JP, et al.Dysembryoplastic neuroepithelial tumor: a surgically curable tumor of young patients with intractable partial seizures. Neurosurgery. 1988;23:545–556.CrossRefGoogle ScholarPubMed
33.Annegers, JF, Grabow, JD, Groover, RV, et al.Seizures after head trauma: a population study. Neurology. 1980;30:683–689.CrossRefGoogle ScholarPubMed
34.Annegers, JF, Hauser, WA, Beghi, E, et al.The risk of unprovoked seizures after encephalitis and meningitis. Neurology. 1988;38:1407–1410.CrossRefGoogle Scholar
35.Sanchetee, PC, Venkataraman, CA, Djamija, RM, et al.Epilepsy as a manifestation of neurocysticercosis. J Assoc Physicians India. 1991;39:325–328.Google ScholarPubMed
36.Grattan-Smith, JD, Harvey, AS, Desmond, PM. et al.Hippocampal sclerosis in children with intractable temporal lobe epilepsy: detection with MR imaging. Am J Roentgenol. 1993;161:1045–1048.CrossRefGoogle ScholarPubMed
37.Kido, DK, Tien, RD, Lee, B, et al.Hippocampal pathology. Neuroimaging Clin N Am. 1997;7:51–65.Google ScholarPubMed
38.Prayson, RA, Reith, JD, Najm, IM. Mesial temporal sclerosis: a clinicopathologic study of 27 patients, including 5 with coexistent cortical dysplasia. Arch Pathol Lab Med. 1996;120:532–536.Google ScholarPubMed
39.Liu, Z, Mikati, M, Holmes, GL. Mesial temporal sclerosis: pathogenesis and significance. Pediair Neurol. 1995;12:5–16.CrossRefGoogle ScholarPubMed
40.Sloviter, RS. The functional organization of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsy. Ann Neurol. 1994;35:640–654.CrossRefGoogle Scholar
41.Babb, TL, Brown, WJ, Pretorius, J, et al.Temporal lobe volumetric cell densities in temporal lobe epilepsy. Epilepsia. 1984;25:729–740.CrossRefGoogle ScholarPubMed
42.Mathern, GW, Babb, TI, Vickrey, BG, et al.Traumatic compared to non-traumatic clinical-pathologic associations in temporal lobe epilepsy. Epilepsy Res. 1994;19:129–139.CrossRefGoogle ScholarPubMed
43.McNamara, JO. Cellular and molecular basis of epilepsy. J Neurosci. 1994;14:3413–3425.CrossRefGoogle ScholarPubMed
44.Kuzniecky, R, de la Sayette, V, Ethier, R, et al.Magnetic resonance imaging in temporal lobe epilepsy: pathological correlations. Ann Neurol. 1987;22:341–347.CrossRefGoogle ScholarPubMed
45.Spencer, SS. The relative contributions of MRI, SPECT, and PET imaging in epilepsy. Epilepsia. 1994;35(suppl 6):72–89.CrossRefGoogle ScholarPubMed
46.Meiners, LC, van Gils, A, Jansen, GH, et al.Temporal lobe epilepsy: the various MR appearances of histologically proven mesial temporal sclerosis. Am J Neuro Radiol. 1994;15:1547–1555.Google ScholarPubMed
47.Heinz, R, Ferris, N, Lee, EK, et al.MR and positron emission tomography in the diagnosis of surgically correctable temporal lobe epilepsy. Am J Neuro Radiol. 1994;15:1341–1348.Google ScholarPubMed
48.Jack, CR Jr, Sharbrough, FW, Cascino, GD, et al.Magnetic resonance image-based hippocampal volumetry: correlation with outcome after temporal lobectomy. Ann Neurol. 1992;31:138–146.CrossRefGoogle ScholarPubMed
49.Jackson, GD, Connelly, A, Duncan, JS, et al.Detection of hippocampal pathology in intractable partial epilepsy: increased sensitivity with quantitative magnetic resonance T2 relaxometry. Neurology. 1993;43:1793–1799.CrossRefGoogle ScholarPubMed
50.Kim, JH, Tien, RD, Felsberg, GJ, et al.Clinical significance of asymmetry of the fornix and mamillary body on MR in hippocampal sclerosis. Am J Neuro Radiol. 1995;16:509–515.Google ScholarPubMed
51.Garcia, PA, Laxer, KD, Barbaro, NM, et al.Prognostic value of qualitative magnetic resonance imaging hippocampal abnormalities in patients undergoing temporal lobectomy for medically refractory seizures. Epilepsia. 1994;35:520–524.CrossRefGoogle ScholarPubMed
52.Jack, CR Jr, Trenerry, MR, Cascino, GD, et al.Bilaterally symmetric hippocampi and surgical outcome. Neurology. 1995;45:1353–1358.CrossRefGoogle ScholarPubMed
53.Léveillé, J, Demonceau, G, Walovitch, RC. Intrasubject comparison between technetium-99m-ECD and technetium-99m-HMPAO in healthy human subjects. J Nucl Med. 1992;33:480–484.Google ScholarPubMed
54.Lavy, S, Malamed, E, Portnoy, Z, et al.Interictal regional cerebral blood flow in patients with partial seizures. Neurology. 1976;26:418–422.CrossRefGoogle ScholarPubMed
55.Rowe, CC, Berkovic, SF, Austin, MC, et al.Patterns of postictal cerebral blood flow in temporal lobe epilepsy: qualitative and quantitative analysis. Neurology. 1991;41:1096–1103.CrossRefGoogle ScholarPubMed
56.DeCarli, C, McIntosh, AR, Blaxton, TA. Use of positron emission tomography for the evaluation of epilepsy. Neuroimaging Clin N Am. 1995;5:623–645.Google ScholarPubMed
57.Saha, GP, MacIntyre, WJ. Go, RT. Radiopharmaceuticals for brain imaging. Semin Nucl Med. 1994;24:324–349.CrossRefGoogle ScholarPubMed
58.Engel, J, Henry, TR, Risinger, MW, et al.Presurgical evaluation for partial epilepsy: relative contributions of chronic depth-electrode recordings versus FDG-PET and scalpsphenoidal ictal EEG. Neurology. 1990;40:1670–1677.CrossRefGoogle ScholarPubMed
59.Delbeke, D, Lawrence, SK, Abou-Khalil, BW, et al.Postsurgical outcome of patients with uncontrolled complex partial seizures and temporal lobe hypometabolism on 18FDG-positron emission tomography. Invest Radiol. 1996;31:261–166.CrossRefGoogle ScholarPubMed
60.Dungan, DH, Karis, JP, Blum, DE, et al.Imaging evaluation of temporal lobe epilepsy. Proceedings of the ASNR. Chicago, Ill: April 26, 1995; Paper #288 on page 154.Google Scholar
61.Castillo, M, Kwock, L, Mukherji, SK. Clinical applications of proton MR spectroscopy. Am J Neuro Radiol. 1996;17:1–15.Google ScholarPubMed
62.Urenjak, J, Williams, SR, Gadian, DG, et al.Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-w astrocyte progenitors, and immature oligodendrocytes in vitro. J Neurochem. 1992;59:55–61.CrossRefGoogle ScholarPubMed
63.Hugg, JW, Duijn, JH, Matson, GB, et al.Elevated lactate and alkalosis in chronic human brain infarction observed by 1H and 31P MR spectroscopic imaging. J Cereb Blood Flow Metab. 1992;12:734–744.CrossRefGoogle ScholarPubMed
64.Breiter, SN, Arroyo, S, Mathews, VP, et al.Proton MR spectroscopy in patients with seizure disorders. Am J Neuro Radiol. 1994;15:373–384.Google ScholarPubMed
65.Ende, GR, Laxer, KD, Knowlton, RD, et al.Temporal lobe epilepsy: bilateral hippocampal metabolite changes revealed at proton MR spectroscopic imaging. Radiology. 1997;202:809–817.CrossRefGoogle ScholarPubMed