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Neurobiological features of binge eating disorder

Published online by Cambridge University Press:  04 November 2015

Iris M. Balodis*
Affiliation:
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Carlos M. Grilo
Affiliation:
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA Department of Psychology, Yale University School of Medicine, New Haven, Connecticut, USA CASAColumbia, Yale University School of Medicine, New Haven, Connecticut, USA
Marc N. Potenza
Affiliation:
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA CASAColumbia, Yale University School of Medicine, New Haven, Connecticut, USA Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA
*
*Address for correspondence: Iris M. Balodis, Department of Psychiatry, Yale University, 1 Church Street, New Haven, CT 06511, USA. (Email: [email protected])

Abstract

Biobehavioral features associated with binge-eating disorder (BED) have been investigated; however, few systematic reviews to date have described neuroimaging findings from studies of BED. Emerging functional and structural studies support BED as having unique and overlapping neural features as compared with other disorders. Neuroimaging studies provide evidence linking heightened responses to palatable food cues with prefrontal areas, particularly the orbitofrontal cortex (OFC), with specific relationships to hunger and reward-sensitivity measures. While few studies to date have investigated non-food-cue responses; these suggest a generalized hypofunctioning in frontostriatal areas during reward and inhibitory control processes. Early studies applying neuroimaging to treatment efforts suggest that targeting neural function underlying motivational processes may prove important in the treatment of BED.

Type
Review Articles
Copyright
Copyright © Cambridge University Press 2015 

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Footnotes

This was supported by P20 DA027844, K24 DK070052, CASAColumbia and the National Center for Responsible Gaming.

References

1. Hudson, JI, Hiripi, E, Pope, HG Jr, Kessler, RC. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol Psychiatry. 2007; 61(3): 348358.Google Scholar
2. Kessler, RC, Berglund, PA, Chiu, WT, et al. The prevalence and correlates of binge eating disorder in the World Health Organization World Mental Health Surveys. Biol Psychiatry. 2013; 73(9): 904914.Google Scholar
3. Grilo, CM, Crosby, RD, Masheb, RM, et al. Overvaluation of shape and weight in binge eating disorder, bulimia nervosa, and sub-threshold bulimia nervosa. Behav Res Ther. 2009; 47(8): 692696.Google Scholar
4. Allison, KC, Grilo, CM, Masheb, RM, Stunkard, AJ. Binge eating disorder and night eating syndrome: a comparative study of disordered eating. J Consult Clin Psychol. 2005; 73(6): 11071115.Google Scholar
5. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 5th ed. Washington, DC: American Psychiatric Association; 2013.Google Scholar
6. Grilo, CM, Hrabosky, JI, White, MA, Allison, KC, Stunkard, AJ, Masheb, RM. Overvaluation of shape and weight in binge eating disorder and overweight controls: refinement of a diagnostic construct. J Abnorm Psychol. 2008; 117(2): 414419.Google Scholar
7. Hudson, JI, Lalonde, JK, Berry, JM, et al. Binge-eating disorder as a distinct familial phenotype in obese individuals. Arch Gen Psychiatry. 2006; 63(3): 313319.Google Scholar
8. Kandel, ER, Schwarz, JH, Jessell, TM. Principles of Neural Science, 4th ed. New York: McGraw-Hill; 2000.Google Scholar
9. Tataranni, PA, DelParigi, A. Functional neuroimaging: a new generation of human brain studies in obesity research. Obes Rev. 2003; 4(4): 229238.CrossRefGoogle ScholarPubMed
10. Schienle, A, Schafer, A, Hermann, A, Vaitl, D. Binge-eating disorder: reward sensitivity and brain activation to images of food. Biol Psychiatry. 2009; 65(8): 654661.Google Scholar
11. Weygandt, M, Schaefer, A, Schienle, A, Haynes, JD. Diagnosing different binge-eating disorders based on reward-related brain activation patterns. Hum Brain Mapp. 2012; 33(9): 21352146.Google Scholar
12. Filbey, FM, Myers, US, Dewitt, S. Reward circuit function in high BMI individuals with compulsive overeating: similarities with addiction. Neuroimage. 2012; 63(4): 18001806.CrossRefGoogle ScholarPubMed
13. Balodis, IM, Kober, H, Worhunsky, PD, et al. Monetary reward processing in obese individuals with and without binge eating disorder. Biol Psychiatry. 2013; 73(9): 877886.Google Scholar
14. Balodis, IM, Molina, ND, Kober, H, et al. Divergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity. Obesity (Silver Spring). 2013; 21(2): 367377.Google Scholar
15. Cambridge, VC, Ziauddeen, H, Nathan, PJ, et al. Neural and behavioral effects of a novel mu opioid receptor antagonist in binge-eating obese people. Biol Psychiatry. 2013; 73(9): 887894.Google Scholar
16. Balodis, IM, Grilo, CM, Kober, H, et al. A pilot study linking reduced fronto-striatal recruitment during reward processing to persistent bingeing following treatment for binge-eating disorder. Int J Eat Disord. 2014; 47(4): 376384.Google Scholar
17. Geliebter, A, Ladell, T, Logan, M, Schneider, T, Sharafi, M, Hirsch, J. Responsivity to food stimuli in obese and lean binge eaters using functional MRI. Appetite. 2006; 46(1): 3135.Google Scholar
18. Karhunen, LJ, Vanninen, EJ, Kuikka, JT, Lappalainen, RI, Tiihonen, J, Uusitupa, MI. Regional cerebral blood flow during exposure to food in obese binge eating women. Psychiatry Res. 2000; 99(1): 2942.CrossRefGoogle ScholarPubMed
19. Wang, GJ, Geliebter, A, Volkow, ND, et al. Enhanced striatal dopamine release during food stimulation in binge eating disorder. Obesity (Silver Spring). 2011; 19(8): 16011608.Google Scholar
20. Schäfer, A, Vaitl, D, Schienle, A. Regional grey matter volume abnormalities in bulimia nervosa and binge-eating disorder. Neuroimage. 2010; 50(2): 639643.Google Scholar
21. Rolls, ET, Yaxley, S, Sienkiewicz, ZJ. Gustatory responses of single neurons in the caudolateral orbitofrontal cortex of the macaque monkey. J Neurophysiol. 1990; 64(4): 10551066.Google Scholar
22. Baylis, LL, Rolls, ET, Baylis, GC. Afferent connections of the caudolateral orbitofrontal cortex taste area of the primate. Neuroscience. 1995; 64(3): 801812.Google Scholar
23. Levy, DJ, Glimcher, PW. The root of all value: a neural common currency for choice. Curr Opin Neurobiol. 2012; 22(6): 10271038.CrossRefGoogle ScholarPubMed
24. Kringelbach, ML. The human orbitofrontal cortex: linking reward to hedonic experience. Nat Rev Neurosci. 2005; 6(9): 691702.Google Scholar
25. Peters, J, Buchel, C. Neural representations of subjective reward value. Behav Brain Res. 2010; 213(2): 135141.CrossRefGoogle ScholarPubMed
26. Rolls, ET. Taste, olfactory, and food reward value processing in the brain. Prog Neurobiol. 2015; 127–128: 6490.Google Scholar
27. Small, DM, Zatorre, RJ, Dagher, A, Evans, AC, Jones-Gotman, M. Changes in brain activity related to eating chocolate: from pleasure to aversion. Brain. 2001; 124(Pt 9): 17201733.Google Scholar
28. Breiter, HC, Aharon, I, Kahneman, D, Dale, A, Shizgal, P. Functional imaging of neural responses to expectancy and experience of monetary gains and losses. Neuron. 2001; 30(2): 619639.Google Scholar
29. Kringelbach, ML, Rolls, ET. The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology. Prog Neurobiol. 2004; 72(5): 341372.CrossRefGoogle ScholarPubMed
30. Gormally, J, Black, S, Daston, S, Rardin, D. The assessment of binge eating severity among obese persons. Addict Behav. 1982; 7: 4755.Google Scholar
31. Carnell, S, Gibson, C, Benson, L, Ochner, CN, Geliebter, A. Neuroimaging and obesity: current knowledge and future directions. Obes Rev. 2012; 13(1): 4356.CrossRefGoogle ScholarPubMed
32. Knutson, B, Adams, CM, Fong, GW, Hommer, D. Anticipation of increasing monetary reward selectively recruits nucleus accumbens. J Neurosci. 2001; 21(16): RC159.Google Scholar
33. Vanderschuren, LJ, Di Ciano, P, Everitt, BJ. Involvement of the dorsal striatum in cue-controlled cocaine seeking. J Neurosci. 2005; 25(38): 86658670.Google Scholar
34. Epstein, LH, Leddy, JJ. Food reinforcement. Appetite. 2006; 46(1): 2225.Google Scholar
35. Carlezon, WA Jr, Wise, RA. Rewarding actions of phencyclidine and related drugs in nucleus accumbens shell and frontal cortex. J Neurosci. 1996; 16(9): 31123122.Google Scholar
36. Haber, SN, Knutson, B. The reward circuit: linking primate anatomy and human imaging. Neuropsychopharmacology. 2010; 35(1): 426.Google Scholar
37. Ito, R, Robbins, TW, Everitt, BJ. Differential control over cocaine-seeking behavior by nucleus accumbens core and shell. Nat Neurosci. 2004; 7(4): 389397.Google Scholar
38. Beck, A, Schlagenhauf, F, Wustenberg, T, et al. Ventral striatal activation during reward anticipation correlates with impulsivity in alcoholics. Biol Psychiatry. 2009; 66(8): 734742.Google Scholar
39. Balodis, IM, Kober, H, Worhunsky, PD, Stevens, MC, Pearlson, GD, Potenza, MN. Diminished frontostriatal activity during processing of monetary rewards and losses in pathological gambling. Biol Psychiatry. 2012; 71(8): 749757.Google Scholar
40. Strohle, A, Stoy, M, Wrase, J, et al. Reward anticipation and outcomes in adult males with attention-deficit/hyperactivity disorder. Neuroimage. 2008; 39(3): 966972.Google Scholar
41. Bohon, C, Stice, E. Reward abnormalities among women with full and subthreshold bulimia nervosa: a functional magnetic resonance imaging study. Int J Eat Disord. 2011; 44(7): 585595.Google Scholar
42. Woolley, JD, Gorno-Tempini, ML, Seeley, WW, et al. Binge eating is associated with right orbitofrontal-insular-striatal atrophy in frontotemporal dementia. Neurology. 2007; 69(14): 14241433.CrossRefGoogle ScholarPubMed
43. Small, DM. Taste representation in the human insula. Brain Struct Funct. 2010; 214(5–6): 551561.Google Scholar
44. Paulus, MP. Decision-making dysfunctions in psychiatry—altered homeostatic processing? Science. 2007; 318(5850): 602606.CrossRefGoogle ScholarPubMed
45. Paulus, MP, Rogalsky, C, Simmons, A, Feinstein, JS, Stein, MB. Increased activation in the right insula during risk-taking decision making is related to harm avoidance and neuroticism. Neuroimage. 2003; 19(4): 14391448.Google Scholar
46. Pelchat, ML, Johnson, A, Chan, R, Valdez, J, Ragland, JD. Images of desire: food-craving activation during fMRI. Neuroimage. 2004; 23(4): 14861493.Google Scholar
47. McCaffery, JM, Haley, AP, Sweet, LH, et al. Differential functional magnetic resonance imaging response to food pictures in successful weight-loss maintainers relative to normal-weight and obese controls. Am J Clin Nutr. 2009; 90(4): 928934.Google Scholar
48. Stice, E, Spoor, S, Bohon, C, Veldhuizen, MG, Small, DM. Relation of reward from food intake and anticipated food intake to obesity: a functional magnetic resonance imaging study. J Abnorm Psychol. 2008; 117(4): 924935.Google Scholar
49. Kober, H, Barrett, LF, Joseph, J, Bliss-Moreau, E, Lindquist, K, Wager, TD. Functional grouping and cortical-subcortical interactions in emotion: a meta-analysis of neuroimaging studies. Neuroimage. 2008; 42(2): 9981031.CrossRefGoogle ScholarPubMed
50. Chambers, RA, Taylor, JR, Potenza, MN. Developmental neurocircuitry of motivation in adolescence: a critical period of addiction vulnerability. Am J Psychiatry. 2003; 160(6): 10411052.Google Scholar
51. Fiorillo, CD, Tobler, PN, Schultz, W. Discrete coding of reward probability and uncertainty by dopamine neurons. Science. 2003; 299(5614): 18981902.CrossRefGoogle ScholarPubMed
52. Robbins, TW. Chemical neuromodulation of frontal-executive functions in humans and other animals. Exp Brain Res. 2000; 133(1): 130138.CrossRefGoogle ScholarPubMed
53. Chamberlain, SR, Mogg, K, Bradley, BP, et al. Effects of mu opioid receptor antagonism on cognition in obese binge-eating individuals. Psychopharmacology (Berl). 2012; 224(4): 501509.Google Scholar
54. Ziauddeen, H, Chamberlain, SR, Nathan, PJ, et al. Effects of the mu-opioid receptor antagonist GSK1521498 on hedonic and consummatory eating behaviour: a proof of mechanism study in binge-eating obese subjects. Mol Psychiatry. 2013; 18(12): 12871293.Google Scholar
55. Castro, DC, Berridge, KC. Advances in the neurobiological bases for food ‘liking’ versus ‘wanting’. Physiol Behav. 2014; 136: 2230.Google Scholar