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Mood Disorders During Pregnancy and Lactation: Defining Issues of Exposure and Treatment

Published online by Cambridge University Press:  07 November 2014

Zachary N. Stowe ,
Kelley Calhoun ,
Clayton Ramsey ,
Noha Sadek  and
Jeffrey Newport
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Abstract

Epidemiologic studies have consistently demonstrated a greater incidence of depressive disorders and anxiety among women. Many women experience these conditions during the reproductive years. The dramatic expanse of literature focusing on the use of medications often has failed to pay homage to the potential impact of the disorders. When considering the extant human and laboratory data on mental illness and stress during pregnancy and the postpartum period, it is evident that some degree of exposure (be it treatment or illness) always occurs. The primary goal of the risk-benefit assessment for the treatment of mental illness during these periods is to assist patients and their families in choosing the path of potential exposure that possesses the least risk for them. Once this decision is made, the goal is to limit the number of exposures for the fetus/neonate.

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Feature Articles
Information
CNS Spectrums , Volume 6 , Issue 2: Female-Specific Mood Disorders , February 2001 , pp. 150 - 166
Copyright
Copyright © Cambridge University Press 2001

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References

REFERENCES

1.Baugh, CL, Stowe, ZN. Treatment issues during pregnancy and lactation. CNS Spectrums. 1999;4(10):34–39.CrossRefGoogle ScholarPubMed
2.Buesching, DP, Glasser, ML, Frate, DA, et al.Progression of depression in the prenatal and postpartum periods. Women Health. 1988;11:61–78.Google Scholar
3.Cutrona, CE. Causal attributions and perinatal depression. J Abnorm Psychol. 1986;92:161–172.CrossRefGoogle Scholar
4.Manly, PC, McMahon, RJ, Bradley, CF, et al.Depressive attributional style and depression following childbirth. J Abnorm Psychol. 1982;91:245–254.CrossRefGoogle ScholarPubMed
5.O'Hara, MW, Rehm, LP, Campbell, SB. Predicting depressive symptomatology: cognitive-behavioural models and postpartum depression. J Abnorm Psychol. 1982;91:457–461.CrossRefGoogle Scholar
6.Watson, J P, Elliott, SA, Rugg, AJ, et al.Psychiatric disorder in pregnancy and the first postnatal year. Br J Psychiatry. 1984;144:453–462.CrossRefGoogle ScholarPubMed
7.Kumar, R, Robson, KM. A prospective study of emotional disorders in childbearing women. Br J Psychiatry. 1984;144:35–47.CrossRefGoogle ScholarPubMed
8.O'Hara, MW, Neunaber, DJ, Zekoski, EM. Prospective study of postpartum depression: prevalence, course, and predictive factors. J Abnorm Psychol. 1984;93:158–171.CrossRefGoogle ScholarPubMed
9.Beck, CT. Screening methods for postpartum depression. J Obstet Gynecol Neonatal Nurs. 1995;24:308–312.CrossRefGoogle ScholarPubMed
10.Affonso, DD, Lovett, S, Paul, SM, et al.A standardized interview that differentiates pregnancy and postpartum symptoms from perinatal clinical depression. Birth. 1990;17:121–130.CrossRefGoogle ScholarPubMed
11.Weissman, MM, Olfson, M. Depression in women: implications for health care research. Science. 1995;269:799–801.CrossRefGoogle ScholarPubMed
12.O'Hara, MW. Postpartum mental disorders. In: Droegemeuller, W, Sciarra, J, eds. Gynecology and Obstetrics. Philadelpia, Pa: Lippincott; 1991.Google Scholar
13.Viguera, AC, Tondo, L, Baldessarini, RJ. Sex differences in response to lithium treatment. Am J Psychiatry. 2000;157:1509–1511.CrossRefGoogle ScholarPubMed
14.McNeil, TF, Kaij, L, Malmquist-Larsson, A. Women with nonorganic psychosis: mental disturbance during pregnancy. Acta Psychiatr Scand. 1984;70:127–139.CrossRefGoogle ScholarPubMed
15.Neziroglu, F, Anemone, R, Yaryura-Tobias, JA. Onset of obsessive compulsive disorder in pregnancy. Am J Psychiatry. 1992;149:947–950.Google ScholarPubMed
16.Pedersen, CA, Stern, RA, Pate, J, et al.Thyroid and adrenal measures during late pregnancy and the puerperium in women who have been major depressed or who become dysphoric postpartum. J Affect Disord. 1993;29:201–211.CrossRefGoogle ScholarPubMed
17.Kendler, KS, Kessler, RC, Neale, MC, et al.The prediction of major depression in women: toward an integrated etiologic model. Am J Psychiatry. 1993;150:1139–1148.Google ScholarPubMed
18.Duffy, CL. Postpartum depression: identifying women at risk. Genesis. 1983;June/July:11–12.Google Scholar
19.Diagnostic and Statistical Manual of Mental Disorders. 4th Ed. Washington, DC: American Psychiatric Association; 1994.Google Scholar
20.Levy, V. The maternity blues in post-partum and postoperative women. Br J Psychiatry. 1987;151:368–372.CrossRefGoogle Scholar
21.Hapgood, CC, Elkind, GS, Wright, JJ. Maternity blues: phenomena and relationship to later postpartum depression. Aust N Z J Psychiatry. 1988;22:299–306.CrossRefGoogle Scholar
22.Kennerley, H, Gath, D. Maternity blues: I. detection and measurement by questionnaire. Br J Psychiatry. 1989;155:356–362.CrossRefGoogle ScholarPubMed
23.O'Hara, MW, Schlechte, JA, Lewis, DA, et al.Prospective study of postpartum blues: biologic and psychosocial factors. Arch Gen Psychiatry. 1991;48:801–806.CrossRefGoogle ScholarPubMed
24.Campbell, SB, Cohn, JF, Flanagan, C, et al.Course and correlates of postpartum depression during the transition to parenthood. Dev Psychopathol. 1992;4:29–47.CrossRefGoogle Scholar
25.Richards, JP. Postnatal depression: a review of recent literature. Br J Gen Pract. 1990;40:472–476.Google ScholarPubMed
26.Cooper, PJ, Murray, L. Course and recurrence of postnatal depression evidence for the specificity of the diagnostic concept. Br J Psychiatry. 1995;166:191–195.CrossRefGoogle ScholarPubMed
27.Troutman, BR, Cutrona, CE. Nonpsychotic postpartum depression among adolescent mothers. J Abnorm Psychol. 1990;99:69–78.CrossRefGoogle ScholarPubMed
28.Stowe, ZN, Nemeroff, CB. Women at risk for postpartum-onset major depression. Am J Obstet Gynecol. 1995;173:639–645.CrossRefGoogle ScholarPubMed
29.Stowe, ZN, Landry, JC, Porter, M. The use of rating scales in postpartum depression. Paper presented at: Annual Meeting of the American Psychiatric Association; May 20–25, 1995; Miami, Fla.Google Scholar
30.O'Hara, MW. Social support, life events and depression during pregnancy and the puerperium. Arch Gen Psychiatry. 1986;43:569–573.CrossRefGoogle ScholarPubMed
31.McGorry, P, Connell, S. The nosology and prognosis of puerperal psychosis: a review. Compr Psychiatry. 1990;31:519–534.CrossRefGoogle ScholarPubMed
32.Schell, LM. Environmental noise and human prenatal growth. Am J Phys Anthropol. 1981;56:63–70.CrossRefGoogle ScholarPubMed
33.Hedegaard, M, Henriksen, TB, Sabroe, S, et al.The relationship between psychological distress during pregnancy and birth weight for gestational age. Acta Obstet Gynecol Scand. 1996;75:32–39.CrossRefGoogle ScholarPubMed
34.Korebrits, C, Ramirez, MM, Watson, L, et al.Maternal corticotropin-releasing hormone is increased with impending preterm birth. J Clin Endocrinold Metab. 1998;83:1585–1591.CrossRefGoogle ScholarPubMed
35.Orr, ST, Miller, CA. Maternal depressive symptoms and the risk of poor pregnancy outcome. Epidemiol Rev. 1995;17:165–171.CrossRefGoogle ScholarPubMed
36.Steer, RA, Scholl, TO, Hediger, ML, et al.Self-reported depression and negative pregnancy outcomes. J Clin Epidemiol. 1992;45:1093–1099.CrossRefGoogle ScholarPubMed
37.Perkins, MR, Bland, JM, Peacock, JL, et al.The effect of anxiety and depression during pregnancy on obstetric complications. Br J Obstet Gynaecol. 1993;100:629–634.CrossRefGoogle Scholar
38.Meijer, A. Child psychiatric sequelae of maternal war stress. Acta Psychiatr Scand. 1985;72:505–511.CrossRefGoogle ScholarPubMed
39.Stott, DH. Follow-up study from birth of the effects of prenatal stresses. Dev Med Child Neurol. 1973;15:770–787.CrossRefGoogle ScholarPubMed
40.Campbell, SB, Cohn, JF, Meyers, T, et al.Depression in first-time mothers: mother-infant interaction and depression chronicity. Dev Psychol. 1995;31:349–357.CrossRefGoogle Scholar
41.Zuckerman, B, Amaro, H, Bauchner, H, et al.Depressive symptoms during pregnancy: relationship to poor health behaviors. Am J Obstet Gynecol. 1989;160:1107–1111.CrossRefGoogle ScholarPubMed
42.Taylor, A, Fisk, NM, Glover, V. Mode of delivery and subsequent stress response [letter]. Lancet. 2000;355:120.CrossRefGoogle ScholarPubMed
43.Meaney, M, Tannenbaum, B, Francis, D, et al.Early environmental programming hypothalamic-pituitary-adrenal responses to stress. Semin Neurosci. 1994;247–259.Google Scholar
44.Herrenkohl, LR, Gala, RR. Serum prolactin levels and maintenance of progeny by prenatally-stressed female offspring. Experientia. 1979;35:702–704.CrossRefGoogle ScholarPubMed
45.Schneider, ML, Roughton, EC, Koehler, AJ, et al.Growth and development following prenatal stress exposure in primates: an examination of ontogenetic vulnerability. Child Dev. 1999;70:263–274.CrossRefGoogle ScholarPubMed
46.Smith, BL, Wills, G, Naylor, D. The effects of prenatal stress on rat offsprings' learning ability. J Psychol. 1981;107:45–51.CrossRefGoogle ScholarPubMed
47.Weller, A, Glaubman, H, Yehuda, S. et al.Acute and repeated gestational stress affect offspring learning and activity in rats. Physiol Behav. 1988;43:139–143.CrossRefGoogle ScholarPubMed
48.Jaiswal, AK, Bhattacharya, SK. Effects of gestational undernutrition, stress and diazepam treatment on spatial discrimination learning and retention in young rats. Indian J Exp Biol. 1993;31:353–359.Google ScholarPubMed
49.Fride, E, Weinstock, M. The effects of prenatal exposure to predictable or unpredictable stress on early development in the rat. Dev Psychobiol. 1984;17:651–660.CrossRefGoogle ScholarPubMed
50.Takahashi, LK. Prenatal stress: consequences of glucocorticoids on hippocampal development and function. Int J Dev Neurosci. 1998;16:199–207.CrossRefGoogle ScholarPubMed
51.McCormick, CM, Smythe, JW, Sharma, S, et al.Sex-specific effects of prenatal stress on hypothalamic-pituitary-adrenal responses to stress and brain glucocorticoid receptor density in adult rats. Brain Res Dev Brain Res. 1995;84:55–61.CrossRefGoogle ScholarPubMed
52.Takahashi, LK, Kalin, NH. Early developmental and temporal characteristics of stress-induced secretion of pituitary-adrenal hormones in prenatally stress rat pups. Brain Res. 1991;558:75–78.CrossRefGoogle ScholarPubMed
53.Fujioka, T, Sakata, Y, Yamaguchi, K, et al.The effects of prenatal stress on the development of hypothalamic paraventricular neurons in fetal rats. Neuroscience. 1999;92:1079–1088.CrossRefGoogle ScholarPubMed
54.Weinstock, M, Matlina, E, Maor, GI, et al.Prenatal stress selectively alters the reactivity of the hypothalamic-pituitary-adrenal system in the female rat. Brain Res. 1992;595:195–200.CrossRefGoogle ScholarPubMed
55.Henry, C, Kabbaj, M, Simon, H, et al.Prenatal stress increases the hypothalamo-pituitary-adrenal axis response in young and adult rats. J Neuroendocrinal. 1994;6:341–345.CrossRefGoogle ScholarPubMed
56.Peters, DA. Prenatal stress: effects on brain biogenic amine and plasma corticosterone levels. Pharmacol Biochem Behav. 1982;17:721–725.CrossRefGoogle ScholarPubMed
57.Koehl, M, Barbazanges, A, Le Moal, M, et al.Prenatal stress induces a phase advance of circadian corticosterone rhythm in adult rats which is prevented by postnatal stress. Brain Res. 1997;759:317–320.CrossRefGoogle ScholarPubMed
58.Barbazanges, A, Piazza, PV, Le Moal, M, et al.Maternal glucocorticoid secretion mediates long-term effects of prenatal stress. J Neurosci. 1996;16:3943–3949.CrossRefGoogle ScholarPubMed
59.Maccari, S, Piazza, PV, Kabbaj, M, et al.Adoption reverses the long-term impairment in glucocorticoid feedback induced by prenatal stress. J Neurosci. 1995;15:110–116.CrossRefGoogle ScholarPubMed
60.Moore, CL, Power, KL. Prenatal stress affects mother-infant interaction in Norway rats. Dev Psychobiol. 1986;19:235–245.CrossRefGoogle ScholarPubMed
61.Power, KL, Moore, CL. Prenatal stress eliminates differential maternal attention to male offspring in Norway rats. Physiol Behav. 1986;38:667–671.CrossRefGoogle ScholarPubMed
62.Clarke, AS, Wittwer, DJ, Abbott, DH, et al.Long-term effects of prenatal stress on HPA axis activity in juvenile rhesus monkeys. Dev Psychobiol. 1994;27:257–269.CrossRefGoogle ScholarPubMed
63.Schneider, ML, Coe, CL, Luback, GR. Endocrine activation mimics the adverse effects of prenatal stress on the neuromotor development of the infant primate. Dev Psychobiol. 1992;25:427–439.CrossRefGoogle ScholarPubMed
64.Alonso, SJ, Navarro, E, Rodriguez, M. Permanent dopaminergic alterations in the nucleus accumbens after prenatal stress. Pharmacol Biochem Behav. 1994;49:353–358.CrossRefGoogle Scholar
65.Alonso, SJ, Navarro, E, Santana, C, et al.Motor lateralization, behavioral despair and dopaminergic brain asymmetry after prenatal stress. Pharmacol Biochem Behav. 1997;58:443–448.CrossRefGoogle ScholarPubMed
66.Fride, E, Dan, Y, Gavish, M, et al.Prenatal stress impairs maternal behavior in a conflict situation and reduces hippocampal benzodiazepine receptors. Life Sci. 1985;36:2103–2109.CrossRefGoogle Scholar
67.Peters, DA. Prenatal stress: effect on development of rat brain adrenergic receptors. Pharmacol Biochem Behav. 1984;21:417–422.CrossRefGoogle ScholarPubMed
68.Henry, C, Guegant, G, Cador, M, et al.Prenatal stress in rats facilitates amphetamine-induced sensitization and induces long-lasting changes in dopamine receptors in the nucleus accumbens. Brain Res. 1995;685:179–186.CrossRefGoogle ScholarPubMed
69.Hayashi, A, Nagaoka, M, Yamada, K, et al.Maternal stress induces synaptic loss and developmental disabilities of offspring. Int J Dev Neurosci. 1998;16:209–216.CrossRefGoogle ScholarPubMed
70.Peters, DA. Maternal stress increases fetal brain and neonatal cerebral cortex 5-hydroxytryptamine synthesis in rats: a possible mechanism by which stress influences brain development. Pharmacol Biochem Behav. 1990;35:943–947.CrossRefGoogle ScholarPubMed
71.Peters, DA. Effects of maternal stress during different gestational periods on the serotonergic system in adult rat offspring. Pharmacol Biochem Behav. 1988;31:839–843.CrossRefGoogle ScholarPubMed
72.Peters, DA. Prenatal stress increases the behavioral response to serotonin agonists and alters open field behavior in the rat. Pharmacol Biochem Behav. 1986;25:873–877.CrossRefGoogle ScholarPubMed
73.Slotkin, TA, Barnes, GA, McCook, EC, et al.Programming of brainstem serotonin transporter development by prenatal glucocorticoids. Brain Res Dev Brain Res. 1996;93:155–161.CrossRefGoogle ScholarPubMed
74.Kay, G, Tarcic, N, Poltyrev, T, et al.Prenatal stress depresses immune function in rats. Physiol Behav. 1998;63:397–402.CrossRefGoogle ScholarPubMed
75.Mazur-Kolecka, B, Kubera, M, Skowron-Cendrzak, A, et al.Effect of prenatal stress on ontogenesis of immunoregulatory cell maturation in mice. Pol J Pharmacol. 1996;48:621–625.Google ScholarPubMed
76.Takahashi, LK, Haglin, C, Kalin, NH. Prenatal stress potentiates stress-induced behavior and reduces the propensity to play in juvenile rats. Physiol Behav. 1992;51:319–323.CrossRefGoogle ScholarPubMed
77.Fride, E, Weinstock, M. Prenatal stress increases anxiety related behavior and alters cerebral lateralization of dopamine activity. Life Sci. 1988;42:1059–1065.CrossRefGoogle ScholarPubMed
78.Weinstock, M, Fride, E, Hertzberg, R. Prenatal stress effects on functional development of the offspring. Prog Brain Res. 1988;73:319–331.CrossRefGoogle ScholarPubMed
79.Vallee, M, Mayo, W, Dellu, F, et al.Prenatal stress induces high anxiety and postnatal handling induces low anxiety in adult offspring: correlation with stress-induced corticosterone secretion. J Neurosci. 1997;17:2626–2636.CrossRefGoogle ScholarPubMed
80.Szuran, T, Zimmerman, E, Pliska, V, et al.Prenatal stress effects on exploratory activity and stress-induced analgesia in rats. Dev Psychobiol. 1991;24:361–372.CrossRefGoogle ScholarPubMed
81.Poltyrev, T, Keshet, GI, Kay, G, et al.Role of experimental conditions in determining differences in exploratory behavior of prenatally stressed rats. Dev Psychobiol. 1996;29:453–462.3.0.CO;2-N>CrossRefGoogle ScholarPubMed
82.Secoli, SR, Teixeira, NA. Chronic prenatal stress affects development and behavioral depression in rats. Stress. 1998;2:273–280.CrossRefGoogle ScholarPubMed
83.Wakshlak, A, Weinstock, M. Neonatal handling reverses behavioral abnormalities induced in rats by prenatal stress. Physiol Behav. 1990;48:289–292.CrossRefGoogle ScholarPubMed
84.Pfister, HP, Muir, JL. Prenatal exposure to predictable and unpredictable novelty stress and oxytocin treatment affects offspring development and behavior in rats. Int J Neurosci. 1992;62:227–241.CrossRefGoogle ScholarPubMed
85.Fride, E, Dan, Y, Feldon, J, et al.Effects of prenatal stress on vulnerability to stress in prepubertal and adult rats. Physiol Behav. 1986;37:681–687.CrossRefGoogle ScholarPubMed
86.Schneider, ML. Prenatal stress exposure alters postnatal behavioral expression under conditions of novelty challenge in rhesus monkey infants. Dev Psychobiol. 1992;25:529–540.CrossRefGoogle ScholarPubMed
87.Clarke, AS, Schneider, ML. Prenatal stress has long-term effects on behavioral responses to stress in juvenile rhesus monkeys. Dev Psychobiol. 1993;26:293–304.CrossRefGoogle ScholarPubMed
88.Avant, KC. Anxiety as a potential factor affecting maternal attachment. J O G N Nurs. 1981;10:416–419.Google ScholarPubMed
89.Brazelton, TB, Tronick, E, Adamson, L, et al.Early mother-infant reciprocity. Ciba Found Symp. 1975;33:137–154.Google Scholar
90.Field, T, Sandberg, D, Garcia, R, et al.Pregnancy problems, postpartum depression, and early mother-infant interactions. Dev Psychol. 1985;21:1152–1156.CrossRefGoogle Scholar
91.Murray, L, Fiori-Cowley, A, Hooper, R, et al.The impact of postnatal depression and associated adversity on early mother-infant interactions and later infant outcome. Child Dev. 1996;67:2512–2526.CrossRefGoogle ScholarPubMed
92.Teti, DM, Messinger, DS, et al.Maternal depression and the quality of early attachment: an examination of infants, preschoolers, and their mothers. Dev Psychol. 1995;31:364–376.CrossRefGoogle Scholar
93.Zahn-Waxler, C, Cummings, EM, McKnew, DH, et al.Altruism, aggression, and social interactions in young children with a manic-depressive parent. Child Dev. 1984;55:112–122.CrossRefGoogle ScholarPubMed
94.Cox, MT, Stowe, ZN, Hostetter, A, et al. Cortisol concentrations in the breast milk of women with major depression. Paper presented at: Annual Meeting of the American Psychiatric Association; May 15, 2000; Chicago, Ill.Google Scholar
95.Anand, KJ, Coskun, V, Thrivikraman, KV, et al.Long-term behavioral effects of repetitive pain in neonatal rat pups. Physiol Behav. 1999;66:627–637.CrossRefGoogle ScholarPubMed
96.Zaharia, MD, Kulczycki, J, Shanks, N, et al.The effects of early postnatal stimulation on Morris water-maze acquisition in adult mice: genetic and maternal factors. Psychopharmacology. 1996;128:227–239.CrossRefGoogle ScholarPubMed
97.Meaney, MJ, Aitken, DH, Van Berkel, C, et al.Effect of neonatal handling on age-related impairments associated with the hippocampus. Science. 1988;239:766–768.CrossRefGoogle ScholarPubMed
98.McCarty, R, Horbaly, WG, Brown, MS, et al.Effects of handling during infancy on the sympathetic-adrenal medullary system of rats. Dev Psychobiol. 1981;14:533–539.CrossRefGoogle ScholarPubMed
99.Levine, S. Maternal and environmental influences on the adrenocortical response to stress in weanling rats. Science. 1967;156:258–260.CrossRefGoogle ScholarPubMed
100.Schreiber, H, Bell, R, Wood, G, et al.Early handling and maternal behavior: Effect on d-amphetamine responsivenes in rats. Pharmacol Biochem Behav. 1978;9:785–789.CrossRefGoogle Scholar
101.Hennessy, MB, Li, J, Lowe, EL, et al.Maternal behavior, pup vocalizations, and pup temperature changes following handling in mice of 2 inbred strains. Dev Psychobiol. 1980;13:573–584.CrossRefGoogle ScholarPubMed
102.Hennessy, MB, Vogt, J, Levine, S. Strain of foster mother determines long-term effects of early handling: Evidence for maternal mediation. Physiol Psychol. 1982;10:153–157.CrossRefGoogle Scholar
103.Smotherman, WP. Mother infant interaction and the modulation of pituitary-adrenal activity in rat pups after early stimulation. Dev Psychobiol. 1983;16:169–176.CrossRefGoogle ScholarPubMed
104.Huot, R, Smith, M, Plotsky, P. Alterations of maternal-infant interaction as a result of maternal separation in Long Evans rats and its behavioral and neuroendocrine consequences. Paper presented at: XXVIIIth Congress of the International Society of Psychoneuroendocrinology; August 1997; San Francisco, Calif.Google Scholar
105.Pauk, J, Kuhn, CM, Field, TM, et al.Positive effects of tactile vs. kinesthetic or vestibular stimulation on neuroendocrine and ODC activity in maternally deprived rat pups. Life Sci. 1986;39:2081–2087.CrossRefGoogle ScholarPubMed
106.Pihoker, C, Owens, MJ, Kuhn, CM, et al.Maternal separation in neonatal rats elicits activation of the hypothalamic-pituitary-adrenocortical axis: a putative role for corticotropin-releasing factor. Psychoneuroendocrinology. 1993;18:485–493.CrossRefGoogle Scholar
107.Walker, CO, Scribner, KA, Cascio, CS, et al.The pituitary-adrenocortical system of neonatal rats is responsive to stress throughout development in a time-dependent and stressor-specific fashion. Endocrinology. 1991;128:1385–1395.CrossRefGoogle Scholar
108.King, JA, Edwards, E. Early stress and genetic influences on hypothalamic-pituitary-adrenal axis functioning in adulthood. Horm Behav. 1999;36:79–85.CrossRefGoogle ScholarPubMed
109.Bremner, J, Southwick, S, Charney, D. The neurobiology of posttraumatic stress disorder: An integration of animal and human research. In: Saigh, P, Bremner, J, eds. Posttraumatic Stress Disorder: A Comprehensive Text. Needham Heights, Mass: Allyn & Bacon; 1999;103–143.Google Scholar
110.Yehuda, R. Psychoneuroendocrinology of post-traumatic stress disorder. Psychiatr Clin North Am. 1998;21:359–379.CrossRefGoogle ScholarPubMed
111.Yehuda, R, Giller, E, Levengood, R, et al.Hypothalamic-pituitary-adrenal functioning in post-traumatic stress disorder. In: Friedman, M, Charney, D, Deutch, A, eds. Neurobiological and Clinical Consequences of Stress: From Normal Adaptation to Post-traumatic Stress Disorder. Philadelphia, Pa: Lippincott-Raven; 1995;351–365.Google Scholar
112.Eghbal-Ahmadi, M, Avishai-Eliner, S, Hatalski, CG, et al.Differential regulation of the expression of corticotropin-releasing factor receptor type 2 (CRF-sub-2) in hypothalamus and amygdala of the immature rat by sensory input and food intake. J Neurosci. 1999;19:3982–3991.CrossRefGoogle Scholar
113.Maestripieri, D, Carroll, KA. Child abuse and neglect: usefulness of the animal data. Psychol Bull. 1998;123:211–223.CrossRefGoogle ScholarPubMed
114.Levine, S, Johnson, DF, Gonzalez, CA. Behavioral and hormonal responses to separation in infant rhesus monkeys and mothers. Behav Neurosci. 1985;99:399–410.CrossRefGoogle ScholarPubMed
115.Wiener, SG, Bayart, F, Faull, KF, et al.Behavioral and physiological responses to maternal separation in squirrel monkeys (Saimiri sciureus). Behav Neurosci. 1990;104:108–115.CrossRefGoogle ScholarPubMed
116.Rosenblum, LA, Paully, GS. The effects of varying environmental demands on maternal and infant behavior. Child Dev. 1984;55:305–314.CrossRefGoogle ScholarPubMed
117.Andrews, M, Rosenblum, L. Developmental consequences of altered dyadic coping patterns in bonnet macaques. In: Roeder, J, Thierry, B, Anderson, J, et al, eds. Current Primatology: Social Development, Learning and Behavior. Strasbourg, France: Universitie Louis Pasteur; 1994;265–271.Google Scholar
118.Andrews, MW, Rosenblum, LA. Attachment in monkey infants raised in variable and low-demand environments. Child Dev. 1991;62:686–693.CrossRefGoogle ScholarPubMed
119.Andrews, M, Rosenblum, L. Relationship between foraging and affiliative social referencing in primates. In: Fa, J, Southwick, C, eds. Ecology and Behavior of Food-Enhanced Primate Groups. New York, NY: Alan R. Liss; 1988;247–268.Google Scholar
120.Coplan, JD, Trost, RC, Owens, MJ, et al.Cerebrospinal fluid concentrations of somatostatin and biogenic amines in grown primates reared by mothers exposed to manipulated foraging conditions. Arch Gen Psychiatry. 1998;55:473–477.CrossRefGoogle ScholarPubMed
121.Coplan, JD, Andrews, M, Rosenblum, L, et al.Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. Proc Natl Acad Sci USA. 1996;93:1619–1623.CrossRefGoogle ScholarPubMed
122.Parry, BL, Javeed, S, Laughlin, GA, et al.Cortisol circadian rhythms during the menstrual cycle and with sleep deprivation in premenstrual dysphoric disorder and normal control subjects. Biol Psychiatry. 2000;48:920–931.CrossRefGoogle ScholarPubMed
123.Miller, LJ. Clinical strategies for the use of psychotropic drugs during pregnancy. Psychiatr Med. 1991;9:275–298.Google ScholarPubMed
124.Altshuler, LL, Cohen, L, Szuba, MP, et al.Pharmacologic management of psychiatric illness in pregnancy: dilemmas and guidelines. Am J Psychiatry. 1996;153:592–606.Google ScholarPubMed
125.Cohen, LS, Heller, VL, Rosenbaum, JF. Treatment guidelines for psychotropic drug use in pregnancy. Psychosomatics. 1989;30:25–33.CrossRefGoogle ScholarPubMed
126.Cohen, LS. Psychotropic drug use in pregnancy. Hosp Community Psychiatry. 1989;40:566–567.Google ScholarPubMed
127.Elia, J, Katz, IR, Simpson, GM. Teratogenicity of psychotherapeutic medications. Psychopharmacol Bull. 1987;23:531–586.Google ScholarPubMed
128.Kerns, LL. Treatment of mental disorders in pregnancy: a review of psychotropic drug risks and benefits. J Nerv Ment Dis. 1986;174:652–659.CrossRefGoogle ScholarPubMed
129.Miller, LJ. Psychiatric medication during pregnancy: understanding and minimizing the risks. Psychiatr Ann. 1994;24:69–75.CrossRefGoogle Scholar
130.Robinson, GE, Stewart, DE, Flak, E. The rational use of psychotropic drugs in pregnancy and postpartum. Can J Psychiatry. 1986;31:183–190.CrossRefGoogle ScholarPubMed
131.Stowe, Z, Newport, D. Depression in women: recognition and treatment. Womens Health Primary Care. 1998;1(suppl):29–39.Google Scholar
132.Wisner, KL, Perel, JM. Psychopharmacologic agents and electroconvulsive therapy during pregnancy and the puerperium. In: Cohen, RL, ed. Psychiatric Consultation in Childbirth Settings: Parent- and Child-Oriented Approaches. New York, NY: Plenum Medical; 1988;165–206.CrossRefGoogle Scholar
133.Wisner, KL, Zarin, DA, Holmboe, ES, et al.Risk-benefit decision making for treatment of depression during pregnancy. Am J Psychiatry. 2000;157:1933–1940.CrossRefGoogle ScholarPubMed
134.Buist, A, Norman, TR, Dennerstein, L, et al.Breastfeeding and the use ol psychotropic medication: a review. J Affect Disord. 1990;19:197–206.CrossRefGoogle Scholar
135.Llewellyn, A, Stowe, Z. Psychotropic medications in lactation. J Clin Psychiatry. 1998;59(suppl 2):41–52.Google ScholarPubMed
136.Wisner, KL, Perel, JM, Findling, RL. Antidepressant treatment during breastfeeding. Am J Psychiatry. 1996;153:1132–1137.Google ScholarPubMed
137.Bolden-Watson, C, Richelson, E. Blockade by newly-developed antidepressants of biogenic amine uptake in rat brain synaptosomes. Life Sci. 1993;52:1023–1029.CrossRefGoogle ScholarPubMed
138.Cusack, B, Nelson, A, Richelson, E. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology. 1994;114:559–565.CrossRefGoogle ScholarPubMed
139.McElhatton, PR, Garbis, HM, Elefant, E, et al.The outcome of pregnancy in 689 women exposed to therapeutic doses of antidepressants. A collaborative study of the European Network of Teratology Information Services (FNTIS). Repro Toxicol. 1996;10:285–294.CrossRefGoogle Scholar
140.Nulman, I, Rovet, J, Stewart, DE, et al.Neturodevelopment ol children exposed in utero to antidepressant drugs. N Engl J Med. 1997;336:258–262.CrossRefGoogle Scholar
141.Goldstein, DJ. Effects of third trimester fluoxetine exposure on the newborn. J Clin Psychopharmacol. 1995;15:417–420.CrossRefGoogle ScholarPubMed
142.Goldstein, DJ, Sundell, KL, Corbin, LA. Birth outcomes in pregnant women taking fluoxetine [letter]. N Engl J Med. 1997;336:872–873.Google ScholarPubMed
143.Ericson, A, Kallen, B, Wiholm, BE. Delivery outcome after the use of antidepressants in early pregnancy. Eur J Clin Pharmacol. 1999;55:503–508.CrossRefGoogle ScholarPubMed
144.Wisner, KL, Perel, JM. Serum nortriptyline levels in nursing mothers and their infants. Am J Psychiatry. 1991;148:1234–1236.Google ScholarPubMed
145.Hostetter, A, Ritchie, JC, Stowe, ZN. Amniotic fluid and umbilical cord blood concentrations of antidepressants in three women. Biol Psychiatry. 2000;48:1032–1034.CrossRefGoogle ScholarPubMed
146.Stowe, ZN, Llewellyn, AM, Strader, JR, et al. Placental passage of antidepressants. Abstract presented at: Annual Meeting of the American Psychiatric Association; May 1997; Toronto, Canada.Google Scholar
147.Eggermont, E. Withdrawal symptoms in neonates associated with maternal imipramine therapy. Lancet. 1973;2(7830):680.CrossRefGoogle ScholarPubMed
148.Misiri, S, Sivertz, K. Tricyclic drugs in pregnancy and lactation: a preliminary report. Int J Psychiatry Med. 1991;21:157–171.CrossRefGoogle Scholar
149.Prentice, A, Brown, R. Fetal tachyarrhythmia and maternal antidepressant treatment. Br Med J. 1989;298:190.CrossRefGoogle ScholarPubMed
150.Webster, PAC. Withdrawal symptoms in neonates associated with maternal antidepressant therapy. Lancet. 1973;2:318–319.CrossRefGoogle ScholarPubMed
151.Spencer, MJ. Fluoxetine hydrochloride (Prozac) toxicity in a neonate. Pediatrics. 1993;92:721–722.CrossRefGoogle ScholarPubMed
152.Dahl, ML, Olhager, E, Ahlner, J, et al.Paroxetine withdrawal syndrome in a neonate [letter]. Br J Psychiatry. 1997;171:391–392.CrossRefGoogle ScholarPubMed
153.Kent, LS, Laidlaw, JD. Suspected congenital sertraline dependence [letter]. Br J Psychiatry. 1995;167:412–413.CrossRefGoogle ScholarPubMed
154.Schou, M. What happened later to the lithium babies? A follow-up study of children born without malformations. Acta Psychiatr Scand. 1976;54:193–197.CrossRefGoogle Scholar
155.Weinstein, MR, Goldfield, M. Cardiovascular malformations with lithium use during pregnancy. Am J Psychiatry. 1975;132:529–531.Google ScholarPubMed
156.Cohen, LS, Friedman, JM, Jefferson, JW, et al.A reevaluation of risk of in utero exposure to lithium. JAMA. 1994;271:146–150.CrossRefGoogle ScholarPubMed
157.Wood, SM, Hytten, FE. The fate of drugs in pregnancy. Clin Obstet Gynaecol. 1981;8:255–259.CrossRefGoogle ScholarPubMed
158.Jones, KL, Lacro, RV, Johnson, KA, et al.Pattern of malformations in the children of women treated with carbamazepine during pregnancy. N Engl J Med. 1989;320:1661–1666.CrossRefGoogle ScholarPubMed
159.Lindhout, D, Schimdt, D. In utero exposure to valproate and neural tube defects. Lancet. 1986;1:1392–1393.CrossRefGoogle ScholarPubMed
160.Rosa, FW. Spina bifida in infants of women treated with carbamazepine during pregnancy. N Engl J Med. 1991;324:674–677.CrossRefGoogle ScholarPubMed
161.Briggs, GG, Freeman, RK, Yaffe, SJ. Drugs in Pregnancy and Lactation. 4th Ed. Baltimore, Md: Williams & Wilkins; 1994.Google Scholar
162.Jensen, PN, Olesen, OV, Bertelsen, A, et al.Citalopram and desmethylcitalopram concentrations in breast milk and in serum of mother and infant. Ther Drug Monit. 1997;19:236–239.CrossRefGoogle ScholarPubMed
163.Kim, J, Misri, S, Riggs, KW, et al. Steroselective excretion of fluoxetine and norfluoxetine in breast milk and neonatal exposure. Paper presented at: Annual Meeting of the American Psychiatric Association; May 1997; San Diego, Calif.Google Scholar
164.Lester, BM, Cucca, J, Andreozzi, L, et al.Possible association between fluoxetine hydrochloride and colic in an infant. J Am Acad Child Adolesc Psychiatry. 1993;32:1253–1255.CrossRefGoogle ScholarPubMed
165.Yoshida, K, Smith, B, Craggs, M, et al.Fluoxetine in breast-milk and developmental outcome of breast-fed infants. Br J Psychiatry. 1998;172:175–178.CrossRefGoogle ScholarPubMed
166.Cohen, LS, Stowe, ZN, Murray, AM, et al. Maternal use of psychotropics during lactation: quantifying infant exposure. Paper presented at: Annual Meeting of the American Psychiatric Association; May 1999; Toronto, Canada.Google Scholar
167.Wright, S, Dawling, S, Ashford, JJ. Excretion of fluvoxamine in breast milk. Br J Clin Pharmacol. 1991;31:209.CrossRefGoogle ScholarPubMed
168.Stowe, ZN, Cohen, LS, Hostetter, A, et al.Paroxetine in breast milk and nursing infants. Am J Psychiatry. 2000;157:185–189.CrossRefGoogle ScholarPubMed
169.Stowe, ZN, Owens, MJ, Landry, JC, et al.Sertraline and desmethylsertraline in human breast milk and nursing infants. Am J Psychiatry. 1997;154:1255–1260.Google ScholarPubMed
170.Mammen, OK, Perel, JM, Rudolph, G, et al.Sertraline and norsertraline levels in three breastfed infants. J Clin Psychiatry. 1997;58:100–103.CrossRefGoogle ScholarPubMed
171.Wisner, KL, Perel, JM, Blumer, J. Serum sertraline and N–desmethylsertraline levels in breast-feeding mother-infant pairs. Am J Psychiatry. 1998;155:690–692.CrossRefGoogle ScholarPubMed
172.Eppersen, CN, Anderson, GM, McDougle, CJ. Sertraline and breast feeding [letter]. N Engl J Med. 1997;336:1189–1190.CrossRefGoogle Scholar
173.Altshuler, LL, Burt, VK, McMullen, M, et al.Breast feeding and sertraline: a 24 hour analysis. J Clin Psychiatry. 1995;56:243–245.Google ScholarPubMed
174.Schmidt, K, Olesen, OV, Jensen, PN. Citalopram and breast-feeding: serum concentration and side effects in the infant. Biol Psychiatry. 2000;47:164–165.CrossRefGoogle ScholarPubMed
175.Lester, BM, Cucca, J, Andreozzi, L, et al.Possible association between fluoxetine hydrochloride and colic in an infant. J Am Acad Child Adolesc Psychiatry. 1993;32:1253–1255.CrossRefGoogle ScholarPubMed
176.Chaudron, LH, Jefferson, JW. Mood stabilizers during breastfeeding: a review. J Clin Psychiatry. 2000;61:79–90.CrossRefGoogle ScholarPubMed
177.Schou, M, Goldfield, MD, Weinstein, MR, et al.Lithium and pregnancy—I. Report from the register of lithium babies. Br Med J. 1973;2:135–136.CrossRefGoogle ScholarPubMed
178.Kirksey, A, Groziak, SM. Maternal drug use: evaluation of risks to breast-fed infants. World Rev Nutr Diet. 1984;43:60–79.CrossRefGoogle ScholarPubMed