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Montreal cognitive assessment for evaluating cognitive impairment in Huntington’s disease: a systematic review

Published online by Cambridge University Press:  07 October 2020

Elena Cecilia Rosca Open the ORCID record for Elena Cecilia Rosca [Opens in a new window]  and
Mihaela Simu
Elena Cecilia Rosca*
Affiliation:
Department of Neurology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania Department of Neurology, Clinical Emergency County Hospital, Timisoara, Romania
Mihaela Simu
Affiliation:
Department of Neurology, “Victor Babes” University of Medicine and Pharmacy, Timisoara, Romania Department of Neurology, Clinical Emergency County Hospital, Timisoara, Romania
*
*Author for correspondence: Elena Cecilia Rosca, Email: [email protected]
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Abstract

Objective

This study aims to systematically review evidence of the accuracy of the Montreal Cognitive Assessment (MoCA) for evaluating the presence of cognitive impairment in patients with Huntington’s disease (HD) and to outline the quality and quantity of research evidence available about the use of the MoCA in this population.

Methods

We conducted a systematic literature review, searching four databases from inception until April 2020.

Results

We identified 26 studies that met the inclusion criteria: two case–control studies comparing the MoCA to a battery of tests, three studies comparing MoCA to Mini-Mental State Examination, two studies estimating the prevalence of cognitive impairment in individuals with HD and 19 studies or clinical trials in which the MoCA was used as an instrument for the cognitive assessment of participants with HD. We found no cross-sectional studies in which participants received the index test (MoCA) and a reference standard diagnostic assessment composed of an extensive neuropsychological battery. The publication period ranged from 2010 to 2020.

Conclusions

In patients with HD, the MoCA provides information about disturbances in general cognitive function. Even if the MoCA demonstrated good sensitivity and specificity when used at the recommended threshold score of 26, further cross-sectional studies are required to examine the optimum cutoff score for detecting cognitive impairments in patients with HD. Moreover, more studies are necessary to determine whether the MoCA adequately assesses cognitive status in individuals with HD.

Keywords

Huntington’s diseasecognitionscreeningMontreal Cognitive Assessmentsystematic review
Type
Review
Information
CNS Spectrums , Volume 27 , Issue 1 , February 2022 , pp. 27 - 45
Copyright
© The Author(s), 2020. Published by Cambridge University Press

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