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Lack of Association of Apolipoprotein E Polymorphism in Obsessive-Compulsive Disorder

Published online by Cambridge University Press:  07 November 2014

Humberto Nicolini ,
Nora Urraca ,
Beatriz Camarena ,
Amalia Gómez ,
Hortensia Martínez ,
Gina Rinetti ,
Carlos Campillo ,
Paola Castelli ,
Rogelio Apiquián  and
Ana Fresán
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Abstract

Obsessive-compulsive disorder (OCD) could be considered a neurodevelopmental disorder, from several lines of evidence. One of the most widely studied genes in these disorders is the apolipoprotein E gene, particularly allele 4. We analyzed for association among patients with OCD versus normal controls and cognitively impaired patients. There were no significant differences between OCD probands compared with population controls. However, the cognitively impaired group showed a higher frequency of allele apolipoprotein E gene compared with normal controls and patients with OCD.

Type
Original Research
Information
CNS Spectrums , Volume 6 , Issue 12: The White Paper Issue 2001 , December 2001 , pp. 978 - 979, 992
Copyright
Copyright © Cambridge University Press 2001

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References

REFERENCES

1. Nicolini, H, Cruz, C, Camarena, B, Páez, F, De la Fuente, JR. Understanding the genetic basis of obsessive-compulsive disorder. CNS Spectrums. 1999;4:32–48.CrossRefGoogle Scholar
2. Bradshaw, J, Sheppard, D. The neurodevelopmental frontostriatal disorders: evolutionary adaptiveness and anomalous lateralization. Brain & Lang. 2000;73:297–320.CrossRefGoogle ScholarPubMed
3. Cavedini, P, Ferri, S, Scarone, S, Bellodi, L. Frontal lobe dysfunction in obsessive-compulsive disorder and major depression: a clinical-neuropsychological study. Psychiatry Res. 1998;79:21–28.CrossRefGoogle Scholar
4. Stevens, K, Hoffman, J, Curtis, H. Sensory-motor aspects of obsessive-compulsive disorder. CNS Spectrums. 1998;3:31–34.CrossRefGoogle Scholar
5. Hymas, N. The neurology of obsessive-compulsive disorder. CNS Spectrums. 1998;3:22–27.CrossRefGoogle Scholar
6. Rosenberg, DR, Keshavan, MS. Toward a neurodevelopmental model of obsessive-compulsive disorder. Biol Psychiatry. 1998;43:623–640.CrossRefGoogle Scholar
7. Purcell, R, Maruff, P, Kyrias, M, Pantelis, C. Cognitive deficits in obsessive-compulsive disorder on testes of frontal-striatal function. Biol Psychiatry. 1998;43:348–357.CrossRefGoogle Scholar
8. Eisen, J, Philips, K, Rasmussen, S. Obsessions and delusions. The relationship Ann. 1999;29:515–522.Google Scholar
9. Selkoe, D. Alzheimer's disease: genotypes, phenotype, and treatments. Science. 1997;275:630–631.CrossRefGoogle ScholarPubMed
10. Harrington, C, Roth, M, Xuereb, J, McKenna, P, Wischik, C. Apolipoprotein E type ε4 allele frequency is increased in patients with schizophrenia. Neurosci Lett. 1995;202:101–104.CrossRefGoogle Scholar
11. Igata-Yi, R, Igata, T, Ishizuka, K, et al. Apolipoprotein E genotype and psychosis. Biol Psychiatry. 1997;41:906–908.CrossRefGoogle ScholarPubMed
12. Chen, J, Hong, C, Chiu, H, et al. Apolipoprotein E genotype and schizophrenia. Neumpsychobiology. 1999;39:141–143.CrossRefGoogle ScholarPubMed
13. Kimura, T, Yokota, S, Igata, R, et al. Apolipoprotein E ε2 and early-onset schizophrenia. Neurosci Lett. 1997;231:53–55.CrossRefGoogle ScholarPubMed
14. Martorell, L, Virgos, C, Valero, J, et al. Schizophrenic women with the APOE ε4 allele have a worse prognosis than those without it. Mol Psychiatry. 2001;6:307–310.CrossRefGoogle Scholar
15. Jönsson, E, Klannfelt, L, Engvall, F, Sedvall, G. Lack of association between schizophrenia and the apolipoprotein E ε4. Eur Arch Psychiatry Clin Neurosci. 1996;246:182–184.CrossRefGoogle Scholar
16. Joöber, R, Rouleau, G, Fon, E, et al. Apolipoprotein E genotype in schizophrenia [letter]. Am J Med Genet. 1996;67:235.CrossRefGoogle ScholarPubMed
17. Zhuy, S, Nöthe, MM, Uhlhass, S, et al. Apolipoprotein E genotype distribution in schizophrenia. Psychiatr Genet. 1996;6:75–79.CrossRefGoogle Scholar
18. Lan, T, Hong, C, Chen, J, Sim, C. Apolipoprotein E-ε4 frequency in patients with schizophrenia. Biol Psychiatry. 1997;42:225–227.Google Scholar
19. Thibaut, F, Coron, B, Hannequin, D, et al. No association of apolipoprotein epsilon 4 allele with schizophrenia even in cognitively impaired patients. Schizophr Res. 1998;30:149–153.CrossRefGoogle ScholarPubMed
20. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. Washington, DC: American Psychiatric Press; 1994;428–434.Google Scholar
21. Caraveo, J, González, C, Ramos, L. Concurrent validity of the DIS experience with psychiatric patient in Mexico City. Hispanic J Behav Sci. 1991;13:63–67.Google Scholar
22. Nicolini, H, Orozco, B, Sánchez de Carmona, M, Páez, F, Loreido, G, de la Fuente, JR. Estudio de traducción y confiabilidad de la escala Yale-Brown en espaeñol para el trastorno obsesivo-compulsivo. Salud Mental. 1996;19(suppl 3):13–16.Google Scholar
23. Apiquicán, R. Escalas de evaluatión en la psicosis. In: Apiquián, R, Fresán, A, Nicolini, H, eds. Evaluación de la Psicopatología Escalas en Espaeñol. Mexico, DF: Ciencias y Cultura Latino Americana; 2000:19–36.Google Scholar
24. Castelli, P, Sosa, AL, Campillo, C, Nicolini, H, Cruz, C. Apolipoprotein E genotypes in a group of elderly subjects of Spanish origin living in Mexico City. Int J Psychogeriatry. In press.Google Scholar
25. Ostrosky-Solis, F, Ardila, A, Roselli, M. Examen neuropsicológico básico en espaeñol. NEUROPSI. Mexico, DF: Laboratorios Bayer SA; 1994.Google Scholar
26. Lahiri, DK, Nurnberger, JI. A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucl Acids Res. 1991;19:5444.CrossRefGoogle ScholarPubMed
27. Wenham, P, Price, W, Blundell, G. Apolipoprotein E genotyping by on-stage PCR. Lancet. 1991;337:1158–1159.CrossRefGoogle Scholar
28. Martinot, JL, Allilaire, JF, Mazoyer, BM, et al. Obsessive-compulsive disorder: a clinical, neuropsychological and positron emission tomography study. Ada Psychiatr Scand. 1990;82:233–242.CrossRefGoogle ScholarPubMed
29. Schmidtke, K, Schorb, A, Winkelmann, G, Hohagen, F. Cognitive frontal lobe dysfunction in obsessive-compulsive disorder. Biol Psychiatry. 1998;43:666–673.CrossRefGoogle ScholarPubMed
30. Schwab, C, Steele, JC, Akiyama, H, McGeer, P. Distinct distribution of apolipoprotein E and beta-amyloid immunoreactivity in the hippocampus of Parkinson dementia complex of Guam. Acta Neuropathol (Berl). 1996;92:378–385.CrossRefGoogle ScholarPubMed