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Investigating Tourette Syndrome as a Neurologic Sequela of Rheumatic Fever

Published online by Cambridge University Press:  07 November 2014

Roger Kurlan
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Abstract

Sydenham's chorea is currently recognized as the only neurologic sequela of rheumatic fever. Recent evidence suggests that there may be a spectrum of neurobehavioral disturbances, particularly including tics and obsessive-compulsive disorder, that develops following streptococcal infection by the process of molecular mimicry, whereby antibodies directed against bacterial antigens cross-react with brain targets. This proposed postinfectious, immune-mediated condition has been termed “pediatric autoimmune neuropsychiatric disorders after streptococcal infection” (PANDAS). This article reviews research evidence in favor and also against the PANDAS concept and discusses the implications of the hypothesis.

Type
Feature Articles
Information
CNS Spectrums , Volume 4 , Issue 2: Tourette Syndrome: Part One , February 1999 , pp. 62 - 67
Copyright
Copyright © Cambridge University Press 1999

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