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Evaluation of the Effects of Severe Depression on Global Cognitive Function and Memory

Published online by Cambridge University Press:  07 November 2014

Shawn M. McClintock ,
C. Munro Cullum ,
Mustafa M. Husain ,
A. John Rush ,
Rebedca G. Knapp ,
Martina Mueller ,
Georgios Petrides ,
Shirlene Sampson  and
Charles H. Kellner
Mustafa M. Husain
Affiliation:
University of Texas Southwestern Medical Center
A. John Rush
Affiliation:
Duke-NUS Graduate Medical School
Martina Mueller
Affiliation:
Medical University of South Carolina
Georgios Petrides
Affiliation:
Hillside Hospital/Long Island Jewish Health System
Shirlene Sampson
Affiliation:
Mayo Clinic
Charles H. Kellner
Affiliation:
Mount Sinai School of Medicine
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Abstract

Introduction: Major depressive disorder (MDD) is thought to negatively impact cognitive function; however, the relationship has not been well explored.

Objective: This study examined the association between depression severity and global cognitive function and memory in subjects with severe, treatment-resistant MDD.

Methods: We enrolled 66 subjects with Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition diagnosed unipolar MDD in a multicenter trial to assess the efficacy and neurocognitive effects of electroconvulsive therapy (ECT). We measured depression severity with the 24 item Hamilton Rating Scale for Depression (HRSD24). Neuropsychologic measures included the Mini Mental State Examination (MMSE), Rey Auditory Verbal Learning Test (RAVLT), and the Complex Figure Test (CFT). Correlational and regression analyses were conducted to explore associations between depression severity and cognitive function.

Results: The mean age of the subjects was 53.6 years (SD=15.8), 65% were female, and mean HRSD24 was 33.9 (SD=6.7). Mean demographic-corrected T-scores for each neurocognitive measure were in the average to borderline range, and HRSD24 values were unrelated to performance on the MMSE, RAVLT immediate and delayed recall, and CFT immediate and delayed recall.

Conclusion: In this sample of severely depressed subjects referred for ECT, depression severity was unrelated to global cognitive function or memory. Future research should examine the interactions between other depressive characteristics and neurocognitive function.

Type
Original Research
Information
CNS Spectrums , Volume 15 , Issue 5 , May 2010 , pp. 304 - 313
Copyright
Copyright © Cambridge University Press 2010

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References

REFERENCES

1.Minor, KL, Champion, JE, Gotlib, IH. Stability of DSM-IV criterion symptoms for major depressive disorder. J Psychiatr Res. 2005;39:415–420.CrossRefGoogle ScholarPubMed
2.Moussavi, S, Chatterji, S, Verdes, E, Tandon, A, Patel, V, Ustun, B. Depression, chronic diseases, and decriments in health: Results from the World Health Survey. Lancet. 2007;370:851–858.CrossRefGoogle Scholar
3.Rush, A., STAR*D: What have we learned? Am J Psychiatry. 2007;164:201–204.CrossRefGoogle ScholarPubMed
4.Zakzanis, KK, Leach, L, Kaplan, E. Neuropsychological Differential Diagnosis. Lisse, The Netherlands: Swets & Zeitlinger; 1999.Google Scholar
5.Shenal, BV, Harrison, DW, Demaree, HA. The neuropsychology of depression: A literature review and preliminary model. Neuropsychol Rev. 2003;13:33–42.CrossRefGoogle ScholarPubMed
6.McClintock, SM, Husain, MM, Greer, TL, Cullum, CM. Association between depression severity and neurocognitive function in major depressive disorder: A review and synthesis. Neuropsychology. 2010;24:9–34.CrossRefGoogle ScholarPubMed
7.Gualtieri, CT, Johnson, LG, Benedict, KB. Neurocognition in depression: Patients on and off medication versus healthy comparison subjects. J Neuropsychiatry Clin Neurosci. 2006;18:217–225.CrossRefGoogle ScholarPubMed
8.Rohling, ML, Green, P, Allen, LM 3rd, Iverson, GL. Depressive symptoms and neurocognitive test scores in patients passing symptom validity tests. Arch Clin Neuropsychol. 2002;17:205–222.CrossRefGoogle ScholarPubMed
9.Trichard, C, Martinot, JL, Alagille, M, et al.Time course of prefrontal lobe dysfunction in severely depressed in-patients: A longitudinal neuropsychological study. Psychol Med. 1995;25:79–85.CrossRefGoogle ScholarPubMed
10.Beck, AT, Steer, RA. Beck Depression Inventory. San Antonio, TX: The Psychological Corporation: 1993.Google Scholar
11.Elderkin-Thompson, V, Kumar, A, Bilker, WB, et al.Neuropsychological deficits among patients with late-onset minor and major depression. Arch Clin Neuropsychol. 2003;18:529–549.CrossRefGoogle ScholarPubMed
12.Burt, T, Prudic, J, Peyser, S, Clark, J, Sackeim, HA. Learning and memory in bipolar and unipolar major depression: Effects of aging. Neuropsychiatry Neuropsychol Behav Neurol. 2000;13:246–253.Google ScholarPubMed
13.Austin, MP, Mitchell, P, Wilhelm, K, et al.Cognitive function in depression: A distinct pattern of frontal impairment in melancholia? Psychol Med. 1999;29:73–85.CrossRefGoogle ScholarPubMed
14.Kellner, CH, Knapp, R, Husain, MM, et al.Comparing bifrontal, bitemporal, and right unilateral electrode placement in ECT: A multisite study from CORE. Br J Psychiatry. 2010;196:226–234.CrossRefGoogle Scholar
15.First, MB, Spitzer, RL, Gibbon, M, Williams, JBW. User's Guide for the Structured Clinical Interview for the DSM-IV Axis I Disorders-Research Version (SCID-I, Version 2.0). Washington, DC: American Psychiatric Press Inc: 1996.Google Scholar
16.Hamilton, M. A rating scale for depression. J Neurol Neurosurg Psychiatry. 1960;23:56–62.CrossRefGoogle ScholarPubMed
17.Hamilton, M. Development of a rating scale for primary depressive illness. Br J Soc Clin Psychol. 1967;6:278–296.CrossRefGoogle ScholarPubMed
18.Folstein, MF, Folstein, SE, Fanjiang, G. MMSE: Mini-Mental State Examination Clinical Guide. Lutz, FL: Psychological Assessment Resources, Inc; 2001.Google Scholar
19.Brown, RG, Scott, LC, Bench, CJ, Dolan, RJ. Cognitive function in depression: Its relationship to the presence and severity of intellectual decline. Psychol Med. 1994;24:829–847.CrossRefGoogle Scholar
20.Lamberty, GJ, Bieliauskas, LA. Distinguishing between depression and dementia in the elderly: A review of neuropsychological findings. Arch Clin Neuropsychol. 1993;8:149–170.CrossRefGoogle ScholarPubMed
21.Rush, AJ, Gullion, CM, Basco, MR, Jarrett, RB, Trivedi, MH. The Inventory of Depressive Symptomatology (IDS): Psychometric properties. Psychol Med. 1996;26:477–486.CrossRefGoogle ScholarPubMed
22.Trivedi, MH, Rush, AJ, Ibrahim, HM, et al.The Inventory of Depressive Symptomatology, Clinician Rating and Self-Report, and the Quick Inventory of Depressive Symptomatology, Clinician Rating and Self-Report in public sector patients with mood disorders: A psychometric evaluation. Psychol Med. 2004;34:73–82.CrossRefGoogle ScholarPubMed
23.Schmidt, M. Rey Auditory Verbal Learning Test: A Handbook. Los Angeles, CA: Western Psychological Services; 1996.Google Scholar
24.Rey, A. L'Examen Clinique en psychologie. Paris, France: Press Universitaire de France: 1964.Google Scholar
25.Rey, A, Osterrieth, PA. Translations of excerpts from Andre Rey's “Psychological examination of traumatic encephalopathy” and P.A. Osterrieth's “The complex figure test” (Corwin, J. & Bylsma, F. W., Trans). Clin Neuropsychol. 1993;7:3–21.Google Scholar
26.Taylor, LB. Localisation of cerebral lesions by psychological testing. Clin Neurosurg. 1969;16:269–287.CrossRefGoogle ScholarPubMed
27.Wilkinson, GS. Wide Range Achievement Test (WRAT-3) Administration Manual. Wilmington, DE: Wide Range Inc; 1993.Google Scholar
28.Spreen, O, Strauss, E. A Compendium of Neuropsychological Tests: Administration, norms, and commentary. 2nd edition. New York, NY: Oxford University Press; 1998.Google Scholar
29.Nunnally, JC, Bernstein, IH. Psychometric Theory. New York, NY: McGraw-Hill; 1994.Google Scholar
30.Strauss, E, Sherman, EMS, Spreen, O. A compendium of neuropsychological tests: Administration, norms, and commentary. Third edition. New York, NY: Oxford University Press: 2006.Google Scholar
31.Folstein, MRFolstein, SE, McHugh, PR. “Mini-Mental State”: A practical method for grading the cognitive state of patients for clinicians. J Psychiatr Res. 1975;12:189–198.CrossRefGoogle Scholar
32.Forsell, YJorm, AF, Winblad, B. Assocation of age, sex, cognitive dysfunction, and disability with major depressive symptoms in an elderly sample. Am J Psychiatry. 1994;151:1600–1604.Google Scholar
33.Alpert, JE, Uebelacker, LA, McLean, NE, Abraham, M, Rosenbaum, JF, Fava, M. The Mini-Mental State Examination among adult outpatients with major depressive disorder. Psychother Psychosom. 1995;63:207–211.CrossRefGoogle ScholarPubMed
34.Burt, DB, Zembar, MJ, Niederehe, G. Depression and memory impairment: A meta-analysis of the association, its pattern, and specificity. Psychol Bull. 1995;117:285–305.CrossRefGoogle ScholarPubMed
35.Delis, DC, Kramer, JH, Kaplan, E, Ober, BA. The California Verbal Learning Test: Research Edition. San Antonio, TX: The Psychological Corporation; 1987.Google Scholar
36.Sandson, J, Albert, MLVarieties of perseveration. Neuropsychologia. 1984;22:715–732.CrossRefGoogle ScholarPubMed
37.Hotz, G, Helm-Estabrooks, N. Perseveration Part I: A review. Brain Inj. 1995;9:151–159.CrossRefGoogle ScholarPubMed
38.Possin, KL, Filoteo, JV, Roesch, SC, Zizak, V, Rilling, LM, Davis, JD. Is a perseveration a perseveration? An evaluation of cognitive error types in patients with subcortical pathology. J Clin Exp Neuropsychol. 2005;27:953–966.CrossRefGoogle ScholarPubMed
39.Robins Wahlin, TB, Bäckman, L, Wahlin, A, Winblad, B. Trail Making Test performance in a community-based sample of healthy very old adults: effects of age on completion time, but not on accuracy. Arch Gerontol Geriatr. 1996;22:87–102.CrossRefGoogle Scholar
40.Ashendorf, L, Jefferson, AL, O'Connor, MK, Chaisson, C, Green, RC, Stern, RA. Trail Making Test errors in normal aging, mild cognitive impairment, and dementia. Arch Clin Neuropsychol. 2008;23:129–137.Google ScholarPubMed
41.Lezak, MD, Howieson, DB, Loring, DW. Neuropsychological Assessment [4th Edition). New York, NY: Oxford University Press; 2004.Google Scholar
42.Fossati, P, Ergis, AM, Allilaire, JF. Problem-solving abilities in unipolar depressed patients: Comparison of performance on the modified version of the Wisconsin and the California sorting tests. Psychiatry Res. 2001;104:145–156.CrossRefGoogle ScholarPubMed
43.Markela-Lerenc, J, Kaiser, S, Fiedler, RWeisbrod, M, Mundt, C. Stroop performance in depressive patients: A preliminary report. J Affect Disord. 2006;94:261–267.CrossRefGoogle ScholarPubMed
44.Delis, DC, Squire, LR, Bihrle, A, Massman, P. Componential analysis of problem-solving ability: Performance of patients with frontal lobe damage and amnesic patients on a new sorting test. Neuropsychologia. 1992;30:683–697.CrossRefGoogle ScholarPubMed
45.Reischies, FM, Neu, P. Comorbidity of mild cognitive disorder and depression: A neuropsychological analysis. Eur Arch Psychiatry Clin Neurosci. 2000;250:186–193.CrossRefGoogle ScholarPubMed
46.Airaksinen, E, Larsson, M, Lundberg, I, Forsell, Y. Cognitive functions in depressive disorders: Evidence from a population-based study. Psychol Med. 2004;34:83–91.CrossRefGoogle ScholarPubMed
47.Porter, RJ, Gallagher, PThompson, JM, Young, AH. Neurocognitive impairment in drug-free patients with major depressive disorder. Br J Psychiatry. 2003;182:214–220.CrossRefGoogle ScholarPubMed
48.Den Hartog, HM, Derix, MM, Van Bemmel, AL, Kremer, B, Jolies, J. Cognitive functioning in young and middle-aged unmedicated out-patients with major depression: Testing the effort and cognitive speed hypotheses. Psychol Med. 2003;33:1443–1451.CrossRefGoogle Scholar
49.Crum, RM, Anthony, JC, Bassett, SS, Folstein, MF. Population-based norms for the Mini-Mental State Examination byh age and education level. JAMA. 1993;269:2386–2391.CrossRefGoogle Scholar