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The Cerebrovascular Model of Depression in Late Life

Published online by Cambridge University Press:  07 November 2014

Jeffrey M. Lyness
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Abstract

Depression in older people, especially depression with an older age of onset, may be a manifestation of acquired brain disease. The cerebrovascular model of depression, often referred to as “vascular depression,” hypothesizes that otherwise clinically occult small vessel brain disease contribute to the pathogeneses of some late-life depressive conditions. This paper reviews several lines of evidence supporting the cerebrovascular model and addresses the limitations of the existing literature. Several directions for future research are noted, including empirical testing of the notion that cerebrovascular disease might underlie the pathogeneses of depression with prominent executive dysfunction or other cognitive impairments. At this time, there are no specific therapeutic options for patients with suspected vascular depression beyond standard approaches to depression treatments, although education about the possibly greater risks of chronicity should be included in treatment planning. Therapy of cerebrovascular risk factors and stroke-risk reduction are important as consistent with general practice guidelines, although it is not known whether this will reduce the incidence or improve the outcome of late-life depression.

Type
Feature Articles
Information
CNS Spectrums , Volume 7 , Issue 10: Geriatric Psychiatry: Emerging Concepts , October 2002 , pp. 712 - 715
Copyright
Copyright © Cambridge University Press 2002

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