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Are the ICD-10 or DSM-5 diagnostic systems able to define those who will benefit from treatment for depression?

Published online by Cambridge University Press:  15 July 2016

Stuart Montgomery
Stuart Montgomery*
Affiliation:
Department of Psychiatry, Imperial College, London, UK
*
*Address for correspondence: Stuart Montgomery, Imperial College London, PO Box 8751, London W13 8WH, UK. (Email: [email protected])
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Abstract

Two widely used diagnostic systems, the International Statistical Classification of Diseases and Related Health Problems (ICD-10) and the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), are reviewed for their ability to define those who will benefit from active treatment rather than placebo. Both systems suffer from a weakness in defining symptoms sufficiently clearly to separate depression from normal mood variations in the general population. Consequently, normal individuals may be medicalized and defined as suffering from and treated for depression. Also, in mild depression, unlike moderate depression, a lack of significant separation of active treatment from placebo has been shown in individual double-blind, placebo-controlled studies and in meta-analyses of these treatment studies. Both systems would be more useful for treatment purposes if they provided a clearer symptomatic definition of moderate depression, as is widely used in pivotal regulatory standard efficacy studies.

Keywords

DepressionDSM-5ICD-10treatmentweaknesses
Type
Opinions
Information
CNS Spectrums , Volume 21 , Special Issue 4: Nosology in DSM5 vs. ICD , August 2016 , pp. 283 - 288
Copyright
© Cambridge University Press 2016 

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