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Antipsychotic long-term treatment in children and young people: a systematic review and meta-analysis of efficacy and tolerability across mental health and neurodevelopmental conditions

Published online by Cambridge University Press:  24 May 2021

Pushpika Singappuli Open the ORCID record for Pushpika Singappuli [Opens in a new window] ,
Edmund Sonuga-Barke  and
Marinos Kyriakopoulos Open the ORCID record for Marinos Kyriakopoulos [Opens in a new window]
Pushpika Singappuli*
Affiliation:
Child and Adolescent Mental Health Services Clinical Academic Group, South London and Maudsley NHS Foundation Trust, London, United Kingdom
Edmund Sonuga-Barke
Affiliation:
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom
Marinos Kyriakopoulos
Affiliation:
Child and Adolescent Mental Health Services Clinical Academic Group, South London and Maudsley NHS Foundation Trust, London, United Kingdom Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom
*
*Author for correspondence: Pushpika Singappuli Email: [email protected]
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Abstract

Antipsychotic medications are used in a wide range of mental health and neurodevelopmental conditions in children and adolescents. Their efficacy and tolerability with long-term use have not been clearly established. We aimed to conduct a systematic review and meta-analysis to evaluate the long-term use of antipsychotics in children and adolescents. All relevant double-blind randomized control trials (RCTs), on any antipsychotic used for 12 weeks or longer in any mental health/neurodevelopmental condition in this age group, were included. We evaluated several efficacy and tolerability measures. Meta-analysis was performed for adverse events. Seven RCTs were identified (n = 939, age = 5-17 years), four on aripiprazole and three on risperidone. All studies reported symptomatic/functional improvements or more time before discontinuation with antipsychotics compared to placebo. Weight gain was identified as a significant side effect with antipsychotics. Serum prolactin was reduced with aripiprazole and increased with risperidone, and abdominal pain/discomfort, respiratory tract infections, were more common with Aripiprazole compared to placebo. Musculoskeletal pain may be more common with aripiprazole compared to placebo. Use of antipsychotics for 12 weeks or longer may be associated with symptomatic/functional improvements, but may be associated with additional side effects compared to short-term treatment. Further research in this population is needed.

Keywords

Antipsychoticslong-termchildrenadolescentsefficacytolerability
Type
Review
Information
CNS Spectrums , Volume 27 , Issue 5 , October 2022 , pp. 570 - 587
Copyright
© The Author(s), 2021. Published by Cambridge University Press

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