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Adherence to Treatment and Therapeutic Strategies in Schizophrenic Patients: The ADHERE Study

Published online by Cambridge University Press:  07 November 2014

José Ramón Gutiérrez-Casares ,
Fernando Cañas ,
David Alonso-Escolano ,
Rebeca Hidalgo-Borrajo  and
Alexander Rodríguez-Morales
José Ramón Gutiérrez-Casares*
Affiliation:
Complejo Hospitalario Universitario de Badajoz
Fernando Cañas
Affiliation:
Hospital Rodríguez Lafora
David Alonso-Escolano
Affiliation:
Janssen-Cilag Spain
*
José Ramón Gutiérrez-Casares, MD, Hospital Infanta Cristina Avda. de Elvas s/n, 06080 Badajoz, Spain; Tel: 34-650-944-021, Fax:, 34-924-24-11-53; E-mail:, [email protected].
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Abstract

Aim: To assess the degree of compliance and adherence to treatment during the follow-up of schizophrenic outpatients after a new therapeutic strategy had been initiated.

Methods: A multicenter, retrospective, prospective, observational study of 1,848 outpatients with schizophrenia or schizoaffective disorders (Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition criteria) was conducted. Patients were treated either with oral or injectable conventional or second generation antipsychotics, and were followed up for 3 months at mental health centers. Patient compliance with the pharmacological treatment was assessed by the use of questionnaires, scales, medication accountability, and the Medication Event Monitoring System. Patients were considered compliant if they reported a high compliance rate (≥80%).

Results: At baseline only 29% of patients on oral medication were compliant compared with 79% of patients on injectable medication (injection counting) (OR= 9.11; 95% CI 6.02-13.77; P<.0001). At the 3 month visit, 84% of patients had changed their treatment and in these, the compliance rate of those on injectable medication was 94% versus 87% of patients taking oral medication (OR= 2.47; 95% CI 1.21-5.05; P=.022).

Conclusion: The use of long-acting injectable antipsychotics, which improves compliance rates and patient follow-up, should facilitate the management of Spanish patients with schizophrenia in mental health centers.

Type
Original Research
Information
CNS Spectrums , Volume 15 , Issue 5 , May 2010 , pp. 327 - 338
Copyright
Copyright © Cambridge University Press 2010

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