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Cognitive-Affective Neuroscience of Depersonalization

Published online by Cambridge University Press:  07 November 2014

Dan J. Stein  and
Daphne Simeon
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Abstract

Depersonalization disorder (DPD) is characterized by a subjective sense of detachment from one's own being and a sense of unreality. An examination of the psychobiology of depersonalization symptoms may be useful in understanding the cognitive-affective neuroscience of embodiment. DPD may be mediated by neurocircuitry and neurotransmitters involved in the integration of sensory processing and of the body schema, and in the mediation of emotional experience and the identification of feelings. For example, DPD has been found to involve autonomic blunting, deactivation of sub-cortical structures, and disturbances in molecular systems in such circuitry. An evolutionary perspective suggests that attenuation of emotional responses, mediated by deactivation of limbic structures, may sometimes be advantageous in response to inescapable stress.

Type
Pearls in Clinical Neuroscience
Information
CNS Spectrums , Volume 14 , Issue 9 , September 2009 , pp. 467 - 471
Copyright
Copyright © Cambridge University Press 2009

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