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Catatonia secondary to anti-N-methyl-D-aspartate receptor (NMDAr) encephalitis: a review

Published online by Cambridge University Press:  30 October 2019

Inês Marques Macedo  and
João Gama Marques Open the ORCID record for João Gama Marques [Opens in a new window]
Inês Marques Macedo
Affiliation:
Clínica Universitária de Psiquiatria e Psicologia Médica, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Europa
João Gama Marques*
Affiliation:
Clínica Universitária de Psiquiatria e Psicologia Médica, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal, Europa Consulta de Esquizofrenia Resistente, Hospital Júlio de Matos, Centro Hospitalar Psiquiátrico de Lisboa, Lisboa, Portugal, Europa .
*
*João Gama Marques Email: [email protected]
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Abstract

Anti-N-methyl-D-aspartate receptor (NMDAr) encephalitis is a relatively recent autoimmune entity, as it was first described in 2007. Given that it is a condition with neuropsychiatric symptoms, its initial symptom is frequently psychiatric in nature. Hence, psychiatrists are often the first physicians to assess these patients and, as so, must recognize this type of encephalitis as a possible cause. Catatonia may be inaugural or develop throughout the course of the disease. Management of patients with anti-NMDAr encephalitis is based on etiologic treatment with immunotherapy and removal of the associated tumor, if any. However, these catatonic patients may have variable responses to etiologic treatment, sometimes with refractory catatonic symptoms, which attests to the necessary urgency to know how to manage these patients. In the clinical setting, physicians appear to be using guidelines originally created to the management of catatonia due to primary psychiatric conditions. In this literature review, catatonia was historically contextualized and anti-NMDAr encephalitis overall described. Finally, catatonia secondary to this type of encephalitis was discussed.

Keywords

Catatoniaanti-NMDAr encephalitisanti-N-methyl-D-aspartate receptor encephalitisneuropsychiatry
Type
Review
Information
CNS Spectrums , Volume 25 , Issue 4 , August 2020 , pp. 475 - 492
Copyright
© Cambridge University Press 2019

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References

Carroll, BTThe universal field hypothesis of catatonia and neuroleptic malignant syndrome. CNS Spectr. 2000; 5(07): 26–33. doi:10.1017/S1092852900013365Google Scholar
Judd, FK, Burrows, GDEncephalitis, catatonia and schizophreniform illness. Aust New Zeal J Psychiatry. 1983; 17(4): 394–396. doi:10.1080/00048678309160020Google Scholar
Peralta, V, Cuesta, MJ, Serrano, JF, Mata, I.The Kahlbaum syndrome: a study of its clinical validity, nosological status, and relationship with schizophrenia and mood disorder. Compr Psychiatry. 38(1): 61–67.Google Scholar
Kaestner, F, Mostert, C, Behnken, A, et al.Therapeutic strategies for catatonia in paraneoplastic encephalitis. World J Biol Psychiatry. 2008; 9(3): 236–240. doi:10.1080/15622970701459802Google Scholar
Ferrafiat, V, Raffin, M, Freri, E, et al.A causality algorithm to guide diagnosis and treatment of catatonia due to autoimmune conditions in children and adolescents. Schizophr Res. 200: 68–76. doi:10.1016/j.schres.2017.06.036Google Scholar
Carroll, BT, Kirkhart, R, Ahuja, N, et al.Katatonia: a new conceptual understanding of catatonia and a new rating scale. Psychiatry. 2008; 5(12): 42–50.Google Scholar
Dhossche, DM, Wachtel, LECatatonia is hidden in plain sight among different pediatric disorders: a review article. Pediatr Neurol. 2010; 43(5): 307–315. doi:10.1016/j.pediatrneurol.2010.07.001Google Scholar
Fink, M.Catatonia from its creation to DSM-V: considerations for ICD. Indian J Psychiatry. 2011; 53(3): 214. doi:10.4103/0019-5545.86810Google Scholar
Carroll, BT, Goforth, HW, Thomas, C, et al.Review of adjunctive glutamate antagonist therapy in the treatment of catatonic syndromes. J Neuropsychiatry Clin Neurosci. 2007; 19(4): 406–412. doi:10.1176/jnp.2007.19.4.406Google Scholar
Carroll, BT, Anfinson, TJ, Kennedy, JC, Yendrek, R, Boutros, M, Bilon, A.Catatonic disorder due to general medical conditions. J Neuropsychiatry Clin Neurosci. 1994; 6(2): 122–133. doi:10.1176/jnp.6.2.122Google Scholar
Daniels, J.Catatonia: clinical aspects and neurobiological correlates. J Neuropsychiatry Clin Neurosci. 2009; 21(4): 371–380. doi:10.1176/jnp.2009.21.4.371Google Scholar
Lee, A, Glick, DB, Dinwiddie, SH, Rosa, MO, Marcolin, MAElectroconvulsive therapy in a pediatric patient with malignant catatonia and paraneoplastic limbic encephalitis. J ECT. 2006; 22(4): 267–270. doi:10.1097/01.yct.0000244236.72049.9eGoogle Scholar
van der Heijden, FMMA, Tuinier, S, Arts, NJM, Hoogendoorn, MLC, Kahn, RS, Verhoeven, WMA. Catatonia: disappeared or under-diagnosed? Psychopathology. 2005; 38(1): 3–8. doi:10.1159/000083964Google Scholar
Carroll, BT, Spetie, L.Catatonia on the consultation-liaison service: a replication study. Int J Psychiatry Med. 1994; 24(4): 329-337. doi:10.2190/GTPP-MHH3-HKCP-R2NHGoogle Scholar
Cottencin, O, Warembourg, F, de Chouly de Lenclave, MB, et al.Catatonia and consultation-liaison psychiatry study of 12 cases. Prog Neuropsychopharmacol Biol Psychiatry. 2007; 31(6): 1170–1176. doi:10.1016/j.pnpbp.2007.04.006Google Scholar
Jaimes-Albornoz , W, Serra-Mestres , J.Prevalence and clinical correlations of catatonia in older adults referred to a liaison psychiatry service in a general hospital. Gen Hosp Psychiatry. 2013; 35(5): 512–516. doi:10.1016/j.genhosppsych.2013.04.009Google Scholar
Oldham, MA, Lee, HBCatatonia vis-à-vis delirium: the significance of recognizing catatonia in altered mental status. Gen Hosp Psychiatry. 2015; 37(6): 554–559. doi:10.1016/j.genhosppsych.2015.06.011Google Scholar
Ramírez-Bermúdez, J, Aguilar-Venegas , LC, Calero-Moscoso , C, et al.Neurology-psychiatry interface in central nervous system diseases. Gac Med Mex. 146(2): 108–111.Google Scholar
Smith, JH, Smith, VD, Philbrick, KL, Kumar, N.Catatonic disorder due to a general medical or psychiatric condition. J Neuropsychiatry Clin Neurosci. 2012; 24(2): 198–207. doi:10.1176/appi.neuropsych.11060120Google Scholar
Lahutte, B, Cornic, F, Bonnot, O, et al.Multidisciplinary approach of organic catatonia in children and adolescents may improve treatment decision making. Prog Neuropsychopharmacol Biol Psychiatry. 2008; 32(6): 1393–1398. doi:10.1016/j.pnpbp.2008.02.015Google Scholar
Fink, M, Taylor, MACatatonia: subtype or syndrome in DSM? Am J Psychiatry. 2006; 163(11): 1875–1876. doi:10.1176/ajp.2006.163.11.1875Google Scholar
Taylor, MA, Fink, M.Catatonia in Psychiatric Classification: A Home of Its Own. Am J Psychiatry. 2003; 160(7): 1233–1241. doi:10.1176/appi.ajp.160.7.1233Google Scholar
Sahaya, K, Lardizabal, D.Catatonia in encephalitis and nonconvulsive seizures: a case report and review of the literature. Epilepsy Behav. 2010; 17(3): 420–425. doi:10.1016/j.yebeh.2010.01.008Google Scholar
Philbrick, KL, Rummans, TAMalignant catatonia. J Neuropsychiatry Clin Neurosci. 1994; 6(1): 1–13. doi:10.1176/jnp.6.1.1Google Scholar
Looper, KJPotential medical and surgical complications of serotonergic antidepressant medications. Psychosomatics. 2007; 48(1): 1–9. doi:10.1176/appi.psy.48.1.1Google Scholar
Gillman, PKUnderstanding toxidromes: serotonin toxicity: a commentary on Montanes-Rada et al. J Clin Psychopharmacol. 2005; 25(6): 625– 626http://www.ncbi.nlm.nih.gov/pubmed/16282860Google Scholar
Boyer, EW, Shannon, M.The serotonin syndrome. N Engl J Med. 2005; 352(11): 1112–1120. doi:10.1056/NEJMra041867Google Scholar
Benarous, X, Consoli, A, Raffin, M, et al.Validation of the pediatric catatonia rating scale (PCRS). Schizophr Res. 2016; 176(2-3): 378–386. doi:10.1016/j.schres.2016.06.020Google Scholar
Bush, G, Fink, M, Petrides, G, Dowling, F, Francis, A. Catatonia., I. Rating scale and standardized examination. Acta Psychiatr Scand. 1996; 93(2): 129–136http://www.ncbi.nlm.nih.gov/pubmed/8686483 10.1111/j.1600-0447.1996.tb09814.xGoogle Scholar
Romanowicz, M, Sola, CLElectroconvulsive therapy-responsive catatonia in a medically complicated patient. J ECT. 2010; 26(3): 234–237. doi:10.1097/YCT.0b013e3181c18a8cGoogle Scholar
Ali, S, Welch, CA, Park, LT, et al.Encephalitis and catatonia treated with ECT. Cogn Behav Neurol. 2008; 21(1): 46–51. doi:10.1097/WNN.0b013e318168464aGoogle Scholar
Talbot-Stern , JK, Green, T, Royle, TJPsychiatric manifestations of systemic illness. Emerg Med Clin North Am. 2000; 18(2): 199–209, vii-viii.10.1016/S0733-8627(05)70118-8Google Scholar
Frame, DS, Kercher, EEAcute psychosis. Functional versus organic. Emerg Med Clin North Am. 1991; 9(1): 123–136.Google Scholar
Larson, EW, Richelson, E.Organic causes of mania. Mayo Clin Proc. 1988; 63(9): 906–912.Google Scholar
Barry, H, Hardiman, O, Healy, DG, et al.Anti-NMDA receptor encephalitis: an important differential diagnosis in psychosis. Br J Psychiatry. 2011; 199(6): 508–509.Google Scholar
Marsh, CMPsychiatric presentations of medical illness. Psychiatr Clin North Am. 1997; 20(1): 181–204.Google Scholar
Babington, PW, Spiegel, DRTreatment of catatonia with olanzapine and amantadine. Psychosomatics. 2007; 48(6): 534–536. doi:10.1176/appi.psy.48.6.534Google Scholar
Falkai, P, Wobrock, T, Lieberman, J, et al.World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 1: acute treatment of schizophrenia. World J Biol Psychiatry. 2005; 6(3): 132–191http://www.ncbi.nlm.nih.gov/pubmed/16173147 10.1080/15622970510030090Google Scholar
Dhossche, DM, Carroll, BT, Carroll, TDIs there a common neuronal basis for autism and catatonia? Int Rev Neurobiol. 72; 2006: 151–164. doi:10.1016/S0074-7742(05)72009-2Google Scholar
Shill, HA, Stacy, MAMalignant catatonia secondary to sporadic encephalitis lethargica. J Neurol Neurosurg Psychiatry. 2000; 69(3): 402–403.Google Scholar
Mann, SC, Caroff, SN, Bleier, HR, Antelo, RE, Un, H.Electroconvulsive therapy of the lethal catatonia syndrome. Convuls Ther. 1990; 6(3): 239–247.Google Scholar
Dekleva, KB, Husain, MMSporadic encephalitis lethargica: a case treated successfully with ECT. J Neuropsychiatry Clin Neurosci. 1995; 7(2): 237–239. doi:10.1176/jnp.7.2.237Google Scholar
Slooter, AJC, Braun, KPJ, Balk, FJE, van Nieuwenhuizen, O, van der Hoeven, J.Electroconvulsive therapy for malignant catatonia in childhood. Pediatr Neurol. 2005; 32(3): 190–192. doi:10.1016/j.pediatrneurol.2004.10.004Google Scholar
Consoli, A, Ronen, K, An-Gourfinkel , I, et al.Malignant catatonia due to anti-NMDA-receptor encephalitis in a 17-year-old girl: case report. Child Adolesc Psychiatry Ment Health. 2011; 5(1): 15. doi:10.1186/1753-2000-5-15Google Scholar
Cai, C, Khawaja, L. “Angel dust blues”- a case of phencyclidine-induced catatonia, abstract. Hosp Med. 2018 https://www.shmabstracts.com/abstract/angel-dust-blues-a-case-of-phencyclidine-induced-catatonia/Google Scholar
Lin, C-C , Hung, Y-Y , Tsai, M-C , Huang, T-L Increased serum anti-N-methyl-D-aspartate receptor antibody immunofluorescence in psychiatric patients with past catatonia. PLoS One. 2017; 12(10): e0187156. doi:10.1371/journal.pone.0187156Google Scholar
Northoff, G.What catatonia can tell us about ‘top-down modulation’: a neuropsychiatric hypothesis. Behav Brain Sci. 2002; 25(5): 555–577; discussion 578–604.Google Scholar
Northoff, G, Eckert, J, Fritze, J. Glutamatergic dysfunction in catatonia? Successful treatment of three acute akinetic catatonic patients with the NMDA antagonist amantadine. J Neurol Neurosurg Psychiatry. 1997; 62(4): 404–406.Google Scholar
Thomas, C, Carroll, BT, Maley, RT, Jayanti, K, Koduri, A.Memantine and catatonic schizophrenia. Am J Psychiatry. 2005; 162(3): 626. doi:10.1176/appi.ajp.162.3.626Google Scholar
Whitley, RJ. Viral encephalitis. N Engl J Med. 1990; 323(4): 242–250. doi:10.1056/NEJM199007263230406Google Scholar
Lipkin, WI European consensus on viral encephalitis. Lancet. 1997; 349(9048): 299–300. doi:10.1016/S0140-6736(05)62821-8Google Scholar
Skuster, DZ, Digre, KB, Corbett, JJNeurologic conditions presenting as psychiatric disorders. Psychiatr Clin North Am. 1992; 15(2): 311–333.Google Scholar
Cummings, JLOrganic delusions: phenomenology, anatomical correlations, and review. Br J Psychiatry. 1985; 146: 184–197.Google Scholar
Schimmel, M, Bien, CG, Vincent, A, Schenk, W, Penzien, J.Successful treatment of anti-N-methyl-D-aspartate receptor encephalitis presenting with catatonia. Arch Dis Child. 2009; 94(4): 314–316. doi:10.1136/adc.2008.149021Google Scholar
Kruse, JL, Jeffrey, JK, Davis, MC, Dearlove, J, IsHak, WW, Brooks, JOAnti-N-methyl-D-aspartate receptor encephalitis: a targeted review of clinical presentation, diagnosis, and approaches to psychopharmacologic management. Ann Clin Psychiatry. 2014; 26(2): 111–119.Google Scholar
Bataller, L, Kleopa, KA, Wu, GF, Rossi, JE, Rosenfeld, MR, Dalmau, J.Autoimmune limbic encephalitis in 39 patients: immunophenotypes and outcomes. J Neurol Neurosurg Psychiatry. 2007; 78(4): 381–385. doi:10.1136/jnnp.2006.100644Google Scholar
Ances, BM, Vitaliani, R, Taylor, RA, et al.Treatment-responsive limbic encephalitis identified by neuropil antibodies: MRI and PET correlates. Brain. 2005; 128(Pt 8): 1764–1777. doi:10.1093/brain/awh526Google Scholar
Chapman, MR, Vause, HEAnti-NMDA receptor encephalitis: diagnosis, psychiatric presentation, and treatment. Am J Psychiatry. 2011; 168(3): 245–251. doi:10.1176/appi.ajp.2010.10020181Google Scholar
Lancaster, E, Dalmau, J.Neuronal autoantigens—pathogenesis, associated disorders and antibody testing. Nat Rev Neurol. 2012; 8(7): 380–390. doi:10.1038/nrneurol.2012.99Google Scholar
Dalmau, J, Gleichman, AJ, Hughes, EG, et al.Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol. 2008; 7(12): 1091–1098. doi:10.1016/S1474-4422(08)70224-2Google Scholar
Gultekin, SH, Rosenfeld, MR, Voltz, R, Eichen, J, Posner, JB, Dalmau, J.Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients. Brain. 2000; 123 (Pt 7): 1481–1494.Google Scholar
Lai, M, Hughes, EG, Peng, X, et al.AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location. Ann Neurol. 2009; 65(4): 424–434. doi:10.1002/ana.21589Google Scholar
Lancaster, E, Lai, M, Peng, X, et al.Antibodies to the GABA(B) receptor in limbic encephalitis with seizures: case series and characterisation of the antigen. Lancet Neurol. 2010; 9(1): 67–76. doi:10.1016/S1474-4422(09)70324-2Google Scholar
Hutchinson, M, Waters, P, McHugh, J, et al.Progressive encephalomyelitis, rigidity, and myoclonus: a novel glycine receptor antibody. Neurology. 2008; 71(16): 1291–1292. doi:10.1212/01.wnl.0000327606.50322.f0Google Scholar
Lancaster, E, Martinez-Hernandez , E, Titulaer, MJ, et al.Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome. Neurology. 2011; 77(18): 1698–1701. doi:10.1212/WNL.0b013e3182364a44Google Scholar
Ryan, SA, Costello, DJ, Cassidy, EM, Brown, G, Harrington, HJ, Markx, S.Anti-NMDA receptor encephalitis. J Psychiatr Pract. 2013; 19(2): 157– 161. doi:10.1097/01.pra.0000428562.86705.cdGoogle Scholar
Lynch, DR, Anegawa, NJ, Verdoorn, T, Pritchett, DBN-methyl-D-aspartate receptors: different subunit requirements for binding of glutamate antagonists, glycine antagonists, and channel-blocking agents. Mol Pharmacol. 1994; 45(3): 540–545.Google Scholar
Lau, CG, Zukin, RSNMDA receptor trafficking in synaptic plasticity and neuropsychiatric disorders. Nat Rev Neurosci. 2007; 8(6): 413–426. doi:10.1038/nrn2153Google Scholar
Waxman, EA, Lynch, DRN-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease. Neurosci. 2005; 11(1): 37–49. doi:10.1177/1073858404269012Google Scholar
Dalmau, J, Tüzün, E, Wu, H, et al.Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol. 2007; 61(1): 25–36. doi:10.1002/ana.21050Google Scholar
Gulyayeva, NA, Massie, MJ, Duhamel, KNAnti-NMDA receptor encephalitis: psychiatric presentation and diagnostic challenges from psychosomatic medicine perspective. Palliat Support Care. 2014; 12(02): 159–163. doi:10.1017/S1478951513000515Google Scholar
Vitaliani, R, Mason, W, Ances, B, Zwerdling, T, Jiang, Z, Dalmau, J. Paraneoplastic encephalitis, psychiatric symptoms, and hypoventilation in ovarian teratoma. Ann Neurol. 2005; 58(4): 594–604. doi:10.1002/ana.20614Google Scholar
Iizuka, T, Sakai, F.Anti-nMDA receptor encephalitis–clinical manifestations and pathophysiology. Brain Nerve. 2008; 60(9): 1047–1060http://www.ncbi.nlm.nih.gov/pubmed/18807939Google Scholar
Jones, KC, Schwartz, AC, Hermida, AP, Kahn, DAA case of anti-NMDA receptor encephalitis treated with ECT. J Psychiatr Pract. 2015; 21(5): 374–380. doi:10.1097/PRA.0000000000000100Google Scholar
Dalmau, J, Lancaster, E, Martinez-Hernandez , E, et al.Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol. 2011; 10: 63–74. doi:10.1016/S1474-4422(10)70253-2Google Scholar
Neyens, RR, Gaskill, GE, Chalela, JACritical care management of anti-N-methyl-d-aspartate receptor encephalitis. Crit Care Med. 2018; 46(9): 1514–1521. doi:10.1097/CCM.0000000000003268Google Scholar
Sarkis, RA, Coffey, MJ, Cooper, JJ, Hassan, I, Lennox, B.Anti-N-methyl-d-aspartate receptor encephalitis: a review of psychiatric phenotypes and management considerations: a Report of the American Neuropsychiatric Association Committee on Research. J Neuropsychiatry Clin Neurosci. 2018; 31: 137–142. doi:10.1176/appi.neuropsych.18010005Google Scholar
Florance-Ryan , N, Dalmau, J.Update on anti-N-methyl-D-aspartate receptor encephalitis in children and adolescents. Curr Opin Pediatr. 2010; 22(6): 739–744. doi:10.1097/MOP.0b013e3283402d2fGoogle Scholar
Kayser, MS, Titulaer, MJ, Gresa-Arribas , N, Dalmau, J.Frequency and characteristics of isolated psychiatric episodes in anti–N-methyl-d-aspartate receptor encephalitis. JAMA Neurol. 2013; 70(9): 1133–1139. doi:10.1001/jamaneurol.2013.3216Google Scholar
Hermans, T, Santens, P, Matton, C, et al.Anti-NMDA receptor encephalitis: still unknown and underdiagnosed by physicians and especially by psychiatrists? Acta Clin Belg. 2017; 73(5): 1–4. doi:10.1080/17843286.2017.1392077Google Scholar
Heekin, RD, Catalano, MC, Frontera, AT, Catalano, G. Anti-NMDA receptor encephalitis in a patient with previous psychosis and neurological abnormalities: a diagnostic challenge. Case Rep Psychiatry. 2015; 2015: 253891. doi:10.1155/2015/253891Google Scholar
Titulaer, M, McCracken, L, Gabilondo Cuellar, I, et al.Clinical features, treatment, and outcome of 500 patients with anti-NMDA receptor encephalitis (PL01.001). Neurology. 2012; 78(1 Supplement): PL01.001.Google Scholar
Mohammad, S, Ramanathan, S, Brilot, F, Dale, R.Autoantibody-associated movement disorders. Neuropediatrics. 2013; 44(06): 336–345. doi:10.1055/s-0033-1358603Google Scholar
Titulaer, MJ, McCracken, L, Gabilondo, I, et al.Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol. 2013; 12(2): 157–165. doi:10.1016/S1474-4422(12)70310-1Google Scholar
Irani, SR, Bera, K, Waters, P, et al.N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain. 2010; 133(Pt 6): 1655–1667. doi:10.1093/brain/awq113Google Scholar
Yeshokumar, AK, Sun, LR, Baranano, KW, Klein, JL, Pardo, CAGait disturbance as the presenting symptom in young children with anti-NMDA receptor encephalitis. Pediatrics. 2016; 138(3): e20160901. doi:10.1542/peds.2016-0901Google Scholar
Granata, T, Matricardi, S, Ragona, F, et al.Pediatric NMDAR encephalitis: A single center observation study with a closer look at movement disorders. Eur J Paediatr Neurol. 2018; 22(2): 301–307. doi:10.1016/j.ejpn.2018.01.012Google Scholar
Duan, B-C , Weng, W-C , Lin, K-L , et al.Variations of movement disorders in anti-N-methyl-D-aspartate receptor encephalitis: A nationwide study in Taiwan. Medicine. 2016; 95(37): e4365. doi:10.1097/MD.0000000000004365Google Scholar
Florance, NR, Davis, RL, Lam, C, et al.Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis in children and adolescents. Ann Neurol. 2009; 66(1): 11–18. doi:10.1002/ana.21756Google Scholar
Luca, N, Daengsuwan, T, Dalmau, J, et al.Anti-N-methyl-D-aspartate receptor encephalitis: a newly recognized inflammatory brain disease in children. Arthritis Rheum. 2011; 63(8): 2516–2522. doi:10.1002/art.30437Google Scholar
Armangue, T, Petit-Pedrol , M, Dalmau, J.Autoimmune encephalitis in children. J Child Neurol. 2012; 27(11): 1460–1469. doi:10.1177/0883073812448838Google Scholar
Chatterjee, SS, Ghosal, MK, Mitra, S.Psychosis and catatonia as presenting features of anti-N-methyl-D-aspartate (anti-NMDA) receptor encephalitis. Asian J Psychiatr. 2017; 27: 112. doi:10.1016/j.ajp.2017.02.017Google Scholar
Tsutsui, K, Kanbayashi, T, Takaki, M, et al.N-Methyl-D-aspartate receptor antibody could be a cause of catatonic symptoms in psychiatric patients: case reports and methods for detection. Neuropsychiatr Dis Treat. 2017; 13: 339–345. doi:10.2147/NDT.S125800Google Scholar
Khadem, GM, Heble, S, Kumar, R, White, C.Anti-N-methyl-d-aspartate receptor antibody limbic encephalitis. Intern Med J. 2009; 39(1): 54–56. doi:10.1111/j.1445-5994.2008.01808.xGoogle Scholar
Türkdoğan, D, Orengul, AC, Zaimoğlu, S, Ekinci, G.Anti-N -methyl-d-aspartate (anti-NMDA) receptor encephalitis: rapid and sustained clinical improvement with steroid therapy starting in the late phase. J Child Neurol. 2014; 29(5): 684–687. doi:10.1177/0883073813520497Google Scholar
Tüzün, E, Dalmau, J.Limbic encephalitis and variants: classification, diagnosis and treatment. Neurologist. 2007; 13(5): 261–271. doi:10.1097/NRL.0b013e31813e34a5Google Scholar
Kuo, YL, Tsai, HF, Lai, MC, Lin, CH, Yang, YKAnti-NMDA receptor encephalitis with the initial presentation of psychotic mania. J Clin Neurosci. 2012; 19(6): 896–898. doi:10.1016/j.jocn.2011.10.006Google Scholar
Sansing, LH, Tüzün, E, Ko, MW, Baccon, J, Lynch, DR, Dalmau, J.A patient with encephalitis associated with NMDA receptor antibodies. Nat Clin Pract Neurol. 2007; 3(5): 291–296. doi:10.1038/ncpneuro0493Google Scholar
Seki, M, Suzuki, S, Iizuka, T, et al.Neurological response to early removal of ovarian teratoma in anti-NMDAR encephalitis. J Neurol Neurosurg Psychiatry. 2008; 79(3): 324–326. doi:10.1136/jnnp.2007.136473Google Scholar
Novillo-López, ME, Rossi, JE, Dalmau, J, Masjuan, J.Treatment-responsive subacute limbic encephalitis and NMDA receptor antibodies in a man. Neurology. 2008; 70(9): 728–729. doi:10.1212/01.wnl.0000305981.53537.d9Google Scholar
Nasky, KM, Knittel, DR, Manos, GHPsychosis associated with anti-N-methyl-D-aspartate receptor antibodies. CNS Spectr. 2008; 13(8): 699–703.Google Scholar
Parratt, KL, Allan, M, Lewis, SJG, Dalmau, J, Halmagyi, GM, Spies, JMAcute psychiatric illness in a young woman: an unusual form of encephalitis. Med J Aust. 2009; 191(5): 284–286http://www.ncbi.nlm.nih.gov/pubmed/19740054Google Scholar
Gable, MS, Sheriff, H, Dalmau, J, Tilley, DH, Glaser, CAThe frequency of autoimmune N-methyl-D-aspartate receptor encephalitis surpasses that of individual viral etiologies in young individuals enrolled in the California Encephalitis Project. Clin Infect Dis. 2012; 54(7): 899–904. doi:10.1093/cid/cir1038Google Scholar
Verhelst, H, Verloo, P, Dhondt, K, et al.Anti-NMDA-receptor encephalitis in a 3 year old patient with chromosome 6p21.32 microdeletion including the HLA cluster. Eur J Paediatr Neurol. 2011; 15(2): 163–166. doi:10.1016/j.ejpn.2010.07.004Google Scholar
van de Riet, EHCW, Esseveld, MM, Cuypers, L, Schieveld, JNM. Anti-NMDAR encephalitis: a new, severe and challenging enduring entity. Eur Child Adolesc Psychiatry. 2013; 22(5): 319–323. doi:10.1007/s00787-012-0351-0Google Scholar
Hughes, EG, Peng, X, Gleichman, AJ, et al.Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis. J Neurosci. 2010; 30(17): 5866–5875. doi:10.1523/JNEUROSCI.0167-10.2010Google Scholar
Parenti, A, Jardri, R, Geoffroy, PAHow anti-NMDAR encephalitis sheds light on the mechanisms underlying catatonia: the neural excitatory/inhibitory imbalance model. Psychosomatics. 2016; 57(3): 336–338. doi:10.1016/j.psym.2016.01.007Google Scholar
Lebas, A, Husson, B, Didelot, A, Honnorat, J, Tardieu, M.Expanding spectrum of encephalitis with NMDA receptor antibodies in young children. J Child Neurol. 2010; 25(6): 742–745. doi:10.1177/0883073809343319Google Scholar
McCarthy, A, Dineen, J, McKenna, P, et al.Anti-NMDA receptor encephalitis with associated catatonia during pregnancy. J Neurol. 2012; 259(12): 2632–2635. doi:10.1007/s00415-012-6561-zGoogle Scholar
Yu, AYX, Moore, FGAParaneoplastic encephalitis presenting as postpartum psychosis. Psychosomatics. 2011; 52(6): 568–570. doi:10.1016/j.psym.2011.01.043Google Scholar
Wilson, JE, Shuster, J, Fuchs, C.Anti-NMDA receptor encephalitis in a 14-year-old female presenting as malignant catatonia: medical and psychiatric approach to treatment. Psychosomatics. 2013; 54(6): 585–589. doi:10.1016/j.psym.2013.03.002Google Scholar
Kiani, R, Lawden, M, Eames, P, et al.Anti-NMDA-receptor encephalitis presenting with catatonia and neuroleptic malignant syndrome in patients with intellectual disability and autism. BJPsych Bull. 2015; 39(1): 32–35. doi:10.1192/pb.bp.112.041954Google Scholar
Verfaillie, L, Bissay, V, Vanderbruggen, N, Van Eetvelde, E, Honoré, P, Spapen, H.An unusual case of acute psychosis in an adolescent. Acta Clin Belg. 2013; 68(2): 138–139. doi:10.2143/ACB.3252Google Scholar
Warren, N, Siskind, D, O’Gorman, C.Refining the psychiatric syndrome of anti-N-methyl-d-aspartate receptor encephalitis. Acta Psychiatr Scand. 2018; 138(5): 401–408. doi:10.1111/acps.12941Google Scholar
Graus, F, Titulaer, MJ, Balu, R, et al.A clinical approach to diagnosis of autoimmune encephalitis. Lancet Neurol. 2016; 15(4): 391–404. doi:10.1016/S1474-4422(15)00401-9Google Scholar
Zandi, MS, Paterson, RW, Ellul, MA, et al.Clinical relevance of serum antibodies to extracellular N-methyl-D-aspartate receptor epitopes. J Neurol Neurosurg Psychiatry. 2015; 86(7): 708–713. doi:10.1136/jnnp-2014-308736Google Scholar
Mackay, G, Ahmad, K, Stone, J, et al.NMDA receptor autoantibodies in sporadic Creutzfeldt-Jakob disease. J Neurol. 2012; 259(9): 1979–1981. doi:10.1007/s00415-012-6489-3Google Scholar
Steiner, J, Walter, M, Glanz, W, et al.Increased prevalence of diverse N-methyl-d-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia. JAMA Psychiatry. 2013; 70(3): 271. doi:10.1001/2013.jamapsychiatry.86Google Scholar
Muni, RH, Wennberg, R, Mikulis, DJ, Wong, AMFBilateral horizontal gaze palsy in presumed paraneoplastic brainstem encephalitis associated with a benign ovarian teratoma. J Neuroophthalmol. 2004; 24(2): 114–118.Google Scholar
Vincent, A, Bien, CG, Irani, SR, Waters, P. Autoantibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol. 2011; 10(8): 759–772. doi:10.1016/S1474-4422(11)70096-5Google Scholar
Schmitt, SE, Pargeon, K, Frechette, ES, Hirsch, LJ, Dalmau, J, Friedman, D.Extreme delta brush: a unique EEG pattern in adults with anti-NMDA receptor encephalitis. Neurology. 2012; 79(11): 1094–1100. doi:10.1212/WNL.0b013e3182698cd8Google Scholar
Breese, EH, Dalmau, J, Lennon, VA, Apiwattanakul, M, Sokol, DKAnti-N-methyl-d-aspartate receptor encephalitis: early treatment is beneficial. Pediatr Neurol. 2010; 42(3): 213–214. doi:10.1016/j.pediatrneurol.2009.10.003Google Scholar
Yoshimura, B, Yada, Y, Horigome, T, Kishi, Y.Anti–N-methyl-d-aspartate receptor encephalitis presenting with intermittent catatonia. Psychosomatics. 2015; 56(3): 313–315. doi:10.1016/j.psym.2014.06.005Google Scholar
Irani, SR, Vincent, A. NMDA receptor antibody encephalitis. Curr Neurol Neurosci Rep. 2011; 11(3): 298–304. doi:10.1007/s11910-011-0186-yGoogle Scholar
Barry, H, Byrne, S, Barrett, E, Murphy, KC, Cotter, DRAnti-N-methyl-d-aspartate receptor encephalitis: review of clinical presentation, diagnosis and treatment. BJPsych Bull. 2015; 39(1): 19–23. doi:10.1192/pb.bp.113.045518Google Scholar
Voice, J, Ponterio, JM, Lakhi, N.Psychosis secondary to an incidental teratoma: a “heads-up” for psychiatrists and gynecologists. Arch Womens Ment Health. 2017; 20: 703–707. doi:10.1007/s00737-017-0751-8Google Scholar
Mythri, SV, Mathew, V.Catatonic Syndrome in Anti-NMDA Receptor Encephalitis. Indian J Psychol Med. 2016; 38(2): 152–154. doi:10.4103/0253-7176.178812Google Scholar
Kramina, S, Kevere, L, Bezborodovs, N, et al.Acute psychosis due to non-paraneoplastic anti-NMDA-receptor encephalitis in a teenage girl: case report. PsyCh J. 2015; 4(4): 226–230. doi:10.1002/pchj.121Google Scholar
Kuppuswamy, PS, Takala, CR, Sola, CLManagement of psychiatric symptoms in anti-NMDAR encephalitis: a case series, literature review and future directions. Gen Hosp Psychiatry. 2014; 36(4): 388–391. doi:10.1016/j.genhosppsych.2014.02.010Google Scholar
Liba, Z, Sebronova, V, Komarek, V, Sediva, A, Sedlacek, P.Prevalence and treatment of anti-NMDA receptor encephalitis. Lancet Neurol. 2013; 12(5): 424–425. doi:10.1016/S1474-4422(13)70070-XGoogle Scholar
Scheibe, F, Prüss, H, Mengel, AM, et al.Bortezomib for treatment of therapy-refractory anti-NMDA receptor encephalitis. Neurology. 2017; 88(4): 366–370. doi:10.1212/WNL.0000000000003536Google Scholar
Bowes, E, Levy, F, Lawson, J, Mandalis, A, Mohan, A, Shannon Weickert, C.Anti-N-methyl-D-aspartate encephalitis – a case study of symptomatic progression. Australas Psychiatry. 2015; 23(4): 422–425. doi:10.1177/1039856215588229Google Scholar
Keller, S, Roitman, P, Ben-Hur , T, Bonne, O, Lotan, A. Anti-NMDA receptor encephalitis presenting as an acute psychotic episode in a young woman: an underdiagnosed yet treatable disorder. Case Rep Psychiatry. 2014; 2014: 868325. doi:10.1155/2014/868325Google Scholar
Wong-Kisiel , LC, Ji, T, Renaud, DL, et al.Response to immunotherapy in a 20-month-old boy with anti-NMDA receptor encephalitis. Neurology. 2010; 74(19): 1550–1551. doi:10.1212/WNL.0b013e3181dd41a1Google Scholar
Kashyape, P, Taylor, E, Ng, J, Krishnakumar, D, Kirkham, F, Whitney, A.Successful treatment of two paediatric cases of anti-NMDA receptor encephalitis with cyclophosphamide: the need for early aggressive immunotherapy in tumour negative paediatric patients. Eur J Paediatr Neurol. 2012; 16(1): 74–78. doi:10.1016/j.ejpn.2011.07.005Google Scholar
Kamran Mirza, M, Pogoriler, J, Paral, K, et al.Adjunct therapeutic plasma exchange for anti-N-methyl-D-aspartate receptor antibody encephalitis: a case report and review of literature. J Clin Apher. 2011; 26(6): 362–365. doi:10.1002/jca.20312Google Scholar
DeSena, AD, Greenberg, BM, Graves, D.Three phenotypes of anti–N-methyl-d-aspartate receptor antibody encephalitis in children: prevalence of symptoms and prognosis. Pediatr Neurol. 2014; 51(4): 542–549. doi:10.1016/j.pediatrneurol.2014.04.030Google Scholar
Lee, EM, Kang, JK, Oh, JS, Kim, JS, Shin, Y-W , Kim, C-Y 18F-fluorodeoxyglucose positron-emission tomography findings with anti-N-methyl-D-aspartate receptor encephalitis that showed variable degrees of catatonia: three cases report. J Epilepsy Res. 2014; 4(2): 69–73.Google Scholar
Graus, F, Keime-Guibert , F, Reñe, R, et al.Anti-Hu-associated paraneoplastic encephalomyelitis: analysis of 200 patients. Brain. 2001; 124(Pt 6): 1138–1148.Google Scholar
Iizuka, T, Yoshii, S, Kan, S, et al.Reversible brain atrophy in anti-NMDA receptor encephalitis: a long-term observational study. J Neurol. 2010; 257(10): 1686–1691. doi:10.1007/s00415-010-5604-6Google Scholar
Gabilondo, I, Saiz, A, Galan, L, et al.Analysis of relapses in anti-NMDAR encephalitis. Neurology. 2011; 77 (10): 996–999. doi:10.1212/WNL.0b013e31822cfc6bGoogle Scholar
Alexopoulos, H, Kosmidis, ML, Dalmau, J, Dalakas, MCParaneoplastic anti-NMDAR encephalitis: long term follow-up reveals persistent serum antibodies. J Neurol. 2011; 258(8): 1568–1570. doi:10.1007/s00415-011-5982-4Google Scholar
Tan, A, Shuey, N, Bladin, C.A modern perspective on the differential diagnosis between encephalitis lethargica or anti-NMDA-receptor encephalitis. J Clin Neurosci. 2010; 17(9): 1204–1206. doi:10.1016/j.jocn.2010.01.010Google Scholar
Ramanathan, S, Wong, CH, Fung, VSCLong duration between presentation of probable anti-N-methyl-D-aspartate receptor encephalitis and either clinical relapse or positive serum autoantibodies. J Clin Neurosci. 2013; 20(9): 1322–1323. doi:10.1016/j.jocn.2012.10.023Google Scholar
Uchida, Y, Kato, D, Yamashita, Y, Ozaki, Y, Matsukawa, N.Failure to improve after ovarian resection could be a marker of recurrent ovarian teratoma in anti-NMDAR encephalitis: a case report. Neuropsychiatr Dis Treat. 2018; 14: 339–342. doi:10.2147/NDT.S156603Google Scholar
Kayser, MS, Kohler, CG, Dalmau, J.Psychiatric manifestations of paraneoplastic disorders. Am J Psychiatry. 2010; 167(9): 1039–1050. doi:10.1176/appi.ajp.2010.09101547Google Scholar
Tham, S-L , Kong, K-H A case of anti-NMDAR (N-methyl-D-aspartate receptor) encephalitis: a rehabilitation perspective. NeuroRehabilitation. 2012; 30(2): 109–112. doi:10.3233/NRE-2012-0733Google Scholar
Houtrow, AJ, Bhandal, M, Pratini, NR, Davidson, L, Neufeld, JAThe rehabilitation of children with anti–N-methyl-d-aspartate–receptor encephalitis. Am J Phys Med Rehabil. 2012; 91(5): 435–441. doi:10.1097/PHM.0b013e3182465da6Google Scholar
Keskin, AO, Tanburoglu, A, Idiman, E, Ozturk, V.Anti-N-methyl-d-aspartate receptor encephalitis during pregnancy: a case report. J Obstet Gynaecol Res. 2019; 43: 768–774. doi:10.1111/jog.13892Google Scholar
Ponte, A, Gama Marques, J, Carvalhão Gil, L, Nobrega, C, Pinheiro, S, Brito, A. Catatonic schizophrenia vs anti-NMDA receptor encephalitis – A video case report. Eur Psychiatry. 2016; 33: S584. doi:10.1016/j.eurpsy.2016.01.2168Google Scholar
Palakkuzhiyil, N, Uvais, NA, Moideen, S, Shihabudheen, P.Anti-NMDA-receptor encephalitis presenting with catatonia in a middle aged male. Asian J Psychiatr. 2018; 35: 26–27. doi:10.1016/j.ajp.2018.04.034Google Scholar
Braakman, HMH, Moers-Hornikx , VMP, Arts, BMG, Hupperts, RMM, Nicolai, J.Pearls and Oysters: electroconvulsive therapy in anti-NMDA receptor encephalitis. Neurology. 2010; 75(10): e44–e46. doi:10.1212/WNL.0b013e3181f11dc1Google Scholar
Dhossche, D, Fink, M, Shorter, E, Wachtel, LEAnti-NMDA receptor encephalitis versus pediatric catatonia. Am J Psychiatry. 2011; 168(7): 749–750. doi:10.1176/appi.ajp.2011.11030471Google Scholar
Mann, AP, Grebenciucova, E, Lukas, R VAnti-N-methyl-d-aspartate-receptor encephalitis: diagnosis, optimal management, and challenges. Ther Clin Risk Manag. 2014; 10: 517–525. doi:10.2147/TCRM.S61967Google Scholar
Rey, JM, Walter, G.Half a century of ECT use in young people. Am J Psychiatry. 1997; 154(5): 595–602. doi:10.1176/ajp.154.5.595Google Scholar
Coffey, MJ, Cooper, JJElectroconvulsive therapy in anti-N-methyl-d-aspartate receptor encephalitis. J ECT. 2016; 32(4): 225–229. doi:10.1097/YCT.0000000000000334Google Scholar
Matsumoto, T, Matsumoto, K, Kobayashi, T, Kato, S.Electroconvulsive therapy can improve psychotic symptoms in anti-NMDA-receptor encephalitis. Psychiatry Clin Neurosci. 2012; 66(3): 242–243. doi:10.1111/j.1440-1819.2012.02324.xGoogle Scholar
Mann, A, Machado, NM, Liu, N, Mazin, A-H , Silver, K, Afzal, KIA multidisciplinary approach to the treatment of anti-nmda-receptor antibody encephalitis: a case and review of the literature. J Neuropsychiatry Clin Neurosci. 2012; 24(2): 247–254. doi:10.1176/appi.neuropsych.11070151Google Scholar
Gough, JL, Coebergh, J, Chandra, B, Nilforooshan, R.Electroconvulsive therapy and/or plasmapheresis in autoimmune encephalitis? World J Clin cases. 2016; 4(8): 223–228. doi:10.12998/wjcc.v4.i8.223Google Scholar
Sunwoo, J-S , Jung, DC, Choi, JY, et al.Successful treatment of refractory dyskinesia secondary to anti-N-methyl-d-aspartate receptor encephalitis with electroconvulsive therapy. J ECT. 2016; 32(3): e13–e14. doi:10.1097/YCT.0000000000000313Google Scholar
Amorim, E, McDade, EMRapidly-progressive catatonia responsive to zolpidem in a patient with ovarian teratoma-associated paraneoplastic encephalitis. J Clin Neurosci. 2016; 30: 136–138. doi:10.1016/j.jocn.2016.01.028Google Scholar
Zaw, ZF, Bates, GDReplication of zolpidem test for catatonia in an adolescent. Lancet. 1997; 349(9069): 1914.Google Scholar
Thomas, P, Rascle, C, Mastain, B, Maron, M, Vaiva, G.Test for catatonia with zolpidem. Lancet. 1997; 349(9053): 702. doi:10.1016/S0140-6736(05)60139-0Google Scholar
Medina, M, Cooper, JJRefractory catatonia due to N-methyl-D-aspartate receptor encephalitis responsive to electroconvulsive therapy. J ECT. 2017; 33: 223–224. doi:10.1097/YCT.0000000000000436Google Scholar
Moussa, T, Afzal, K, Cooper, J, Rosenberger, R, Gerstle, K, Wagner-Weiner , L.Pediatric anti-NMDA receptor encephalitis with catatonia: treatment with electroconvulsive therapy. Pediatr Rheumatol. 2019; 17(1): 8. doi:10.1186/s12969-019-0310-0Google Scholar
Tanguturi, YC, Cundiff, AW, Fuchs, C.Anti-N-methyl d-aspartate receptor encephalitis and electroconvulsive therapy. Child Adolesc Psychiatr Clin N Am. 2019; 28(1): 79–89. doi:10.1016/j.chc.2018.07.005Google Scholar
Warren, N, Grote, V, O’Gorman, C, Siskind, D.Electroconvulsive therapy for anti-N-methyl-d-aspartate (NMDA) receptor encephalitis: A systematic review of cases. Brain Stimul. 2019; 12(2): 329–334. doi:10.1016/j.brs.2018.11.016Google Scholar