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Preparation of drug-montmorillonite UV-radiation protection compounds by gas-solid adsorption

Published online by Cambridge University Press:  09 July 2018

C. del Hoyo ,
M. A. Vicente  and
V. Rives
C. del Hoyo
Affiliation:
Departamento de Química Inorgánica, Universidad de Salamanca, 37008-Salamanca, Spain Unidad Asociada IRNASA(CSIC)-Universidad de Salamanca, c/ Cordel de Merinas, s/n, 37008-Salamanca, Spain
M. A. Vicente*
Affiliation:
Unidad Asociada IRNASA(CSIC)-Universidad de Salamanca, c/ Cordel de Merinas, s/n, 37008-Salamanca, Spain Instituto de Recursos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, c/Cordel deMerinas, s/n, 37008- Salamanca, Spain
V. Rives*
Affiliation:
Departamento de Química Inorgánica, Universidad de Salamanca, 37008-Salamanca, Spain Unidad Asociada IRNASA(CSIC)-Universidad de Salamanca, c/ Cordel de Merinas, s/n, 37008-Salamanca, Spain
*
†Deceased
*E-mail: [email protected]
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Abstract

Ethyl cinnamate/montmorillonite intercalation complexes were obtained by gaseous adsorption of the drug on the clay surface. They were characterized by powder X-ray diffraction, differential thermal and thermogravimetric analyses and by visible-UV and IR spectroscopies. It was found that after 1 day of adsorption, most of the drug enters the interlayer space of the clay by substitution of water molecules, and is removed only after heating at high temperature. In addition, a portion is physisorbed on the external surface of the crystallites, being removed easily below 100°C. The interlayer complex improves the protecting ability of the pure clay or the pure drug against ultraviolet radiation, specially in the so-called ‘C’ range (290–190 nm).

Keywords

montmorilloniteethyl cinnamatedrug-clay interactiongas-solid adsorptionUV radiation protection
Type
Research Article
Information
Clay Minerals , Volume 36 , Issue 4 , December 2001 , pp. 541 - 546
Copyright
Copyright © The Mineralogical Society of Great Britain and Ireland 2001

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