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Clay-lipid nanohybrids: towards influenza vaccines and beyond

Published online by Cambridge University Press:  02 January 2018

Bernd Wicklein ,
Margarita Darder ,
Pilar Aranda ,
María Angeles Martín Del Burgo ,
Gustavo Del Real ,
Mariano Esteban  and
Eduardo Ruiz-Hitzky
Bernd Wicklein*
Affiliation:
Instituto de Ciencia de Materiales de Madrid, CSIC, C/ Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain
Margarita Darder
Affiliation:
Instituto de Ciencia de Materiales de Madrid, CSIC, C/ Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain
Pilar Aranda
Affiliation:
Instituto de Ciencia de Materiales de Madrid, CSIC, C/ Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain
María Angeles Martín Del Burgo
Affiliation:
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra. de la Coruña Km 7.5, 28040 Madrid, Spain
Gustavo Del Real
Affiliation:
Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra. de la Coruña Km 7.5, 28040 Madrid, Spain
Mariano Esteban
Affiliation:
Centro Nacional de Biotecnología, CSIC, Darwin 3, Campus de Cantoblanco, 28049 Madrid, Spain
Eduardo Ruiz-Hitzky
Affiliation:
Instituto de Ciencia de Materiales de Madrid, CSIC, C/ Sor Juana Inés de la Cruz 3, 28049 Madrid, Spain
*
*E-mail: [email protected]
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Abstract

The design of nanostructured materials based on natural components, such as clay minerals, offers new solutions to biomedical challenges such as more efficient and storage-stable vaccines. Clay-lipid hybrid materials have proved useful as adjuvants in influenza vaccines and with a possible projection to leishmaniasis vaccines and other pathogens. Self-assembly of phospholipid molecules on the surface of microfibrous sepiolite and lamellar Mg/Al layered double hydroxide renders a biocompatible lipid bilayer membrane that ensures non-degrading immobilization of proteins and other biological species including viral particles and DNA (deoxyribonucleic acid). Immunization tests in mice showed the superior immunogenicity of a clay-lipid-supported virus compared to a commercial aluminium hydroxide adjuvant.

Keywords

clay-lipid hybridinfluenza virusadjuvantimmunizationvaccine
Type
Research Article
Information
Clay Minerals , Volume 51 , Issue 4 , September 2016 , pp. 529 - 538
Copyright
Copyright © The Mineralogical Society of Great Britain and Ireland 2016

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Footnotes

†

This work was originally presented during the Euroclay 2015 conference held in July 2015 in Edinburgh, UK. This author was awarded the Martin Vivaldi Award.

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