Hostname: page-component-cd9895bd7-dzt6s Total loading time: 0 Render date: 2024-12-28T11:48:09.718Z Has data issue: false hasContentIssue false
  • English
  • Français

Advances in the development of animal gene transfer

Published online by Cambridge University Press:  01 October 2008

Shi Zhen-Dan ,
Li Wan-Li ,
Zhang Yong-Liang  and
Chen Xue-Jin
Shi Zhen-Dan*
Affiliation:
Department of Animal Science, South China Agricultural University, Guangzhou 510642, China
Li Wan-Li
Affiliation:
Department of Animal Science, South China Agricultural University, Guangzhou 510642, China
Zhang Yong-Liang
Affiliation:
Department of Animal Science, South China Agricultural University, Guangzhou 510642, China
Chen Xue-Jin
Affiliation:
Centre for Laboratory Animals, Shanghai Jiaotong University, Shanghai 200092, China
*
*Corresponding author. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Efficiency and specificity are key limiting factors for the production of transgenic animals. This review describes the recently developed animal gene transfer techniques, including non-site-specific methods of gene transfer into the testis and ovary for easy production of transgenic animals; gene targeting in embryonic stem cells, somatic cells and primordial germ cells for site-specific methods; methods to improve cloning efficiency in gene targeting; and site- and timing-specific gene targeting and controlled expression of transferred genes. In addition, methods of utilizing newly developed RNA interference, combined with the above techniques for controlling gene expression, to produce transgenic animals to spatio-temporally and reversibly knock down specific genes, are also discussed. The merits and disadvantages of each method are covered, as well as the potential use of these methods to develop transgenic animals for breeding new animal lines, to study disease models and to produce therapeutic medicines.

Keywords

gene transfer methodsefficiencyspatio-temporal expressioncontrolled expressionRNA interference
Type
Review Article
Information
Chinese Journal of Agricultural Biotechnology , Volume 5 , Issue 2 , August 2008 , pp. 101 - 106
Copyright
Copyright © China Agricultural University 2008

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Footnotes

First published in Journal of Agricultural Biotechnology 2008, 16(1): 163–168

References

Acosta, J, Carpio, Y, Borroto, I, et al. (2005) Myostatin gene silenced by RNAi show a zebrafish giant phenotype. Journal of Biotechnology 119(4): 324–331.CrossRefGoogle ScholarPubMed
Berg, H and Eckardt, K (1970) Interaction of anthracyclines and anthracyclinones with DNA. Zeitschrift fur Natureforschung, B: Chemie, Biochemic, Biophysik, Biologie 25(4): 362–367.CrossRefGoogle ScholarPubMed
Brinster, RL and Avarbock, MR (1994) Germline transmission of donor haplotype following spermatogonial transplantation. Proceedings of the National Academy of Sciences of the USA 91: 11303–11307.CrossRefGoogle ScholarPubMed
Chen, YF (2002) Trangenic Animals. Beijing, Science Press (in Chinese).Google Scholar
Chen, ZB (2004) RNAi: A Guide to Gene Silencing. Beijing: Chemical Industry Press, pp. 266–297 (in Chinese).Google Scholar
Dai, YF, Vaught, TD, Boone, J, et al. (2002) Targeted disruption of the α-1,3-galactosyltransferase gene in cloned pigs. Nature Biotechnology 20: 251–255.CrossRefGoogle ScholarPubMed
Dann, CT, Alvarado, AL, Hammer, RE, et al. (2006) Heritable and stable gene knockdown in rats. Proceedings of the National Academy of Sciences of the USA 103(30): 11246–11251.CrossRefGoogle ScholarPubMed
Dickins, RA, McJunkin, K, Hernando, E, et al. (2007) Tissue-specific and reversible RNA interference in transgenic mice. Nature Genetics 39(7): 914–921.CrossRefGoogle ScholarPubMed
Gu, H, Zou, YR and Rajewsky, K (1993) Independent control of immunoglobulin switch recombination at individual switch regions evidenced through cre-loxP-mediated gene targeting. Cell 73(6): 1155–1164.CrossRefGoogle ScholarPubMed
Gu, H, Marth, JD, Orban, PC, et al. (1994) Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science 265: 103–106.CrossRefGoogle Scholar
Janeisch, R and Mintz, B (1974) Simian virus 40 DNA sequences in DNA healthy adult mice derived from preimplantation blastocysts injected with viral DNA. Proceedings of the National Academy of Sciences of the USA 71(4): 1250–1254.CrossRefGoogle Scholar
Kim, JH, Jung-Ha, HS, Lee, HT, et al. (1997) Development of a positive method for male stem cell-mediated gene transfer in mouse and pig. Molecular Reproduction and Development 46: 515–526.3.0.CO;2-V>CrossRefGoogle ScholarPubMed
Kistner, A, Gossen, M and Zimmerman, F (1996) Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice. Proceedings of the National Academy of Sciences of the USA 93: 10933–10938.CrossRefGoogle ScholarPubMed
Kuroiwa, Y, Kasinathan, P, Matsushita, H, et al. (2004) Sequential targeting of the genes encoding immunoglobulin-μ and prion protein in cattle. Nature Genetics 36(7): 775–780.CrossRefGoogle ScholarPubMed
Lai, LX, Kolber-Simonds, D, Park, KW, et al. (2002) Production of α-1,3-galactosyltransferase knockout pigs by nuclear transfer cloning. Science 295: 1089–1092.CrossRefGoogle ScholarPubMed
Lai, L, Kang, JX, Li, R, et al. (2006) Generation of cloned transgenic pigs rich in omega-3 fatty acids. Nature Biotechnology 24(4): 435–436.CrossRefGoogle Scholar
Li, M, Indra, AK, Warot, X, et al. (2000) Skin abnormalities generated by temporally controlled RXR mutations in mouse epidermis. Nature 407: 633–636.CrossRefGoogle ScholarPubMed
MacColl, GS, Goldspink, G and Bouloux, PM (1999) Using skeletal muscle as an artificial endocrine tissue. Journal of Endocrinology 162(1): 1–9.CrossRefGoogle ScholarPubMed
McCreath, KJ, Howcroft, J, Campbell, KH, et al. (2000) Production of gene-targeted sheep by nuclear transfer from cultured somatic cells. Nature 405: 1066–1069.CrossRefGoogle ScholarPubMed
Metzger, D and Chambon, P (2001) Site- and time-specific gene targeting in the mouse. Methods 24: 71–80.CrossRefGoogle ScholarPubMed
Metzger, D and Feil, R (1999) Engineering the mouse genome by site-specific recombination. Current Opinion in Biotechnology 10: 470–476.CrossRefGoogle ScholarPubMed
Mueller, S, Prelle, K, Rieger, N, et al. (1999) Chimeric pigs following blastocyst injection of transgenic porcine primordial germ cells. Molecular Reproduction and Development 54(3): 244–254.3.0.CO;2-5>CrossRefGoogle ScholarPubMed
Naito, M, Tajima, A, Yasuda, Y, et al. (1994) Prodution of germline chimeric chickens with high transmission rate of donor-derived gametes produced by transfer of primordial germ cells. Molecular Reproduction and Development 39: 153–161.CrossRefGoogle Scholar
Natesan, S, Molinari, E, Rivera, VM, et al. (1999) A general strategy to enhance the potency of chimeric transcriptional activators. Proceedings of the National Academy of Sciences of the USA 96(24): 13898–13903.CrossRefGoogle ScholarPubMed
Rivera, VM, Ye, XH, Courage, NL, et al. (1999) Long-term regulated expression of growth hormone in mice after intramuscular gene transfer. Proceedings of the National Academy of Sciences of the USA 96: 8657–8662.CrossRefGoogle ScholarPubMed
Shen, W, Li, L, Pan, Q, et al. (2006) Efficient and simple production of transgenic mice and rabbits using the new DMSO-sperm mediated exogenous DNA transfer method. Molecular Reproduction and Development 73: 589–594.CrossRefGoogle ScholarPubMed
Shen, XM, Qiao, GL, Zhang, L, et al. (2002) Construction of transgenic mice carrying enhanced green fluorescent protein gene by seminiferous tubule microinjection. Journal of First Military Medical University 22(3): 250–253 (in Chinese with English abstract).Google ScholarPubMed
Thomas, KR and Capecchi, MR (1987) Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells. Cell 51(3): 503–512.CrossRefGoogle ScholarPubMed
Van de Lavoir, MC, Diamond, JH, Leighton, PA, et al. (2006) Germline transmission of genetically modified primordial germ cells. Nature 441: 766–769.CrossRefGoogle ScholarPubMed
Ventura, A, Meissner, A, Dillon, CP, et al. (2004) Cre-lox-regulated conditional RNA interference from transgenes. Proceedings of the National Academy of Sciences of the USA 101(28): 1380–1385.CrossRefGoogle ScholarPubMed
Wall, RJ, Powell, AM, Paape, MJ, et al. (2005) Genetically enhanced cows resist intramammary Staphylococcus aureus infection. Nature Biotechnology 23(4): 445–451.CrossRefGoogle ScholarPubMed
Wei, PH and Chen, QX (1996) Transgenic Animal. Guangzhou: Guangdong Science and Technology Press.Google Scholar
Yang, SY, Wang, JG, Cui, HX, et al. (2007) Efficient generation of transgenic mice by direct intraovarian injection of plasmid DNA. Biochemical and Biophysical Research Communications 358(1): 266–271.CrossRefGoogle ScholarPubMed
Yang, XY, Li, H, Ma, QW, et al. (2006) Improved efficiency of bovine cloning by autologous somatic cell nuclear transfer. Reproduction 132(5): 733–739.CrossRefGoogle ScholarPubMed
Yu, J and McMahon, AP (2006) Reproducible and inducible knockdown of gene expression in mice. Genesis 44: 252–261.CrossRefGoogle ScholarPubMed
Yuan, J, An, J, Gu, WW, et al. (2007) Experimental study on generation of transgenic mice by combination of intratesticular injection with in vivo electroporation. Journal of South Medical University 27: 168–171 (in Chinese with English abstract).Google Scholar