Hostname: page-component-669899f699-swprf Total loading time: 0 Render date: 2025-04-26T01:46:29.016Z Has data issue: false hasContentIssue false
  • English
  • Français

Vasospastic angina following COVID-19 vaccine-related myocarditis: an underlying cause of chest pain

Published online by Cambridge University Press:  11 January 2023

Atsushi Tanaka Open the ORCID record for Atsushi Tanaka [Opens in a new window] ,
Shoji Fukuoka  and
Hazumu Nagata Open the ORCID record for Hazumu Nagata [Opens in a new window]
Atsushi Tanaka
Affiliation:
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Shoji Fukuoka
Affiliation:
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hazumu Nagata*
Affiliation:
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
*
Author for correspondence: H. Nagata, Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. Tel: +81-92-642-5421; Fax: +81-92-642-5435. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

We present a 13-year-old boy who had recurrent chest pain with elevated cardiac enzymes and abnormal ST segments in electrocardiogram 36 hours after the second dose of BNT162b2 vaccination. Cardiac MRI and coronary angiography with acetylcholine provocation confirmed myocarditis and vasospastic angina, respectively. Coronary vasospasm may play a pivotal role in the chest pain in COVID-19 vaccine-related myocarditis.

Keywords

COVID-19 vaccinemyocarditiscoronary vasospasmvasospastic angina
Type
Brief Report
Information
Cardiology in the Young , Volume 33 , Issue 6 , June 2023 , pp. 1015 - 1017
Check for updates
Copyright
© The Author(s), 2023. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Article purchase

Temporarily unavailable

References

Bozkurt, B, Kamat, I, Hotez, PJ. Myocarditis with COVID-19 mRNA vaccines. Circulation 2021; 144: 471–484.CrossRefGoogle ScholarPubMed
Truong, DT, Dionne, A, Muniz, JC, et al. Clinically suspected myocarditis temporally related to COVID-19 vaccination in adolescents and young adults: suspected myocarditis after COVID-19 vaccination. Circulation 2022; 145: 345–356.CrossRefGoogle Scholar
Vojdani, A, Kharrazian, D. Potential antigenic cross-reactivity between SARS-CoV-2 and human tissue with a possible link to an increase in autoimmune diseases. Clin Immunol 2020; 217: 108480.CrossRefGoogle Scholar
JCS Joint Working Group. Guidelines for diagnosis and treatment of patients with vasospastic angina (Coronary spastic angina) (JCS 2013). Circ J 2014; 78: 2779–2801.CrossRefGoogle Scholar
Yilmaz, A, Mahrholdt, H, Athanasiadis, A, et al. Coronary vasospasm as the underlying cause for chest pain in patients with PVB19 myocarditis. Heart 2008; 94: 1456–1463.CrossRefGoogle ScholarPubMed