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Tricuspid valve endocarditis on a healthy valve—potentially lethal in infants and young children

Published online by Cambridge University Press:  19 August 2008

Solomon E. Levin ,
Raymond Dansky ,
Avram Benatar  and
Selwyn Milner
Solomon E. Levin*
Affiliation:
From the Department of Paediatrics and Child Health, Division of Paediatric Cardiology, University of the Witwatersrand, Johannesburg
Raymond Dansky
Affiliation:
From the Department of Paediatrics and Child Health, Division of Paediatric Cardiology, University of the Witwatersrand, Johannesburg
Avram Benatar
Affiliation:
From the Department of Paediatrics and Child Health, Division of Paediatric Cardiology, University of the Witwatersrand, Johannesburg
Selwyn Milner
Affiliation:
From the Department of Paediatrics and Child Health, Division of Paediatric Cardiology, University of the Witwatersrand, Johannesburg
*
Professor Solomon E. Levin, Department of Paediatrics and Child Health, Medical School, University of the Witwatersrand, York Road, Johannesburg 2193, South Africa. Tel. 11-488-3191; Fax: 11-643-4318
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Summary

Tricuspid valve endocarditis on a normal valve has been rarely documented in children. In all five previous cases the infecting organism was Staphylococcus aureus. We report five infants and children with tricuspid valve endocarditis, whose ages ranged from four months to four years. In all of them large vegetations were identified by two-dimensional echocardiography. Positive blood cultures were found in four of five patients. Staphylococcus aureus, Corynebacterium species, Haemophilus influenzae and Candida albicans were the respective isolates. There were three deaths, all relatively sudden, 10–33 days after commencement of antibiotic therapy. At the only post mortem carried out in the patient with Candida albicans endocarditis and Down syndrome, there were two large fungating masses straddling the tricuspid valve. They appeared to have obstructed the circulation. Microscopic examination of a lymph node and the thymus showed features consistent with an immune deficiency syndrome. One child has been lost to follow-up. In the remaining survivor, progressively severe tricuspid regurgitation with congestive cardiac failure, necessitated open heart surgery 13 months later. A homograft replacement of the destroyed septal leaflet was carried out. Tricuspid valve endocarditis in an infant or child is a serious and potentially lethal condition. Early surgical intervention to remove large obstructive vegetations appears to be warranted.

Keywords

Infective endocarditis in childrentricuspid valveechocardiographysurgical indications
Type
Original Articles
Information
Cardiology in the Young , Volume 2 , Issue 2 , April 1992 , pp. 191 - 195
Copyright
Copyright © Cambridge University Press 1992

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References

1.Goessler, MC, Riggs, TW, DeLeon, S, Paul, MH. Echocardiographic diagnosis oftricuspid valve endocarditis in a child with a normal heart. Special emphasis on surgical considerations. Ped Cardiol 1982; 2: 141–143.CrossRefGoogle Scholar
2.Musewe, NN, Hecht, BM, Hesslein, PS, Rose, V, Williams, WG. Tricuspid valve endocarditis in two children with normal hearts: diagnosis and therapy of an unusual clinical entity. J Pediatr 1987; 110: 735–738.CrossRefGoogle ScholarPubMed
3.Tornos, MP, Castro, A, Toran, N, Girona, J. Tricuspid valve endocarditis in children with normal hearts. Am Heart J 1989; 118: 624–625.CrossRefGoogle ScholarPubMed
4.De Villiers, FPR, Levin, SE. Association ofCandida endocarditis of the tricuspid valve with Down Syndrome. Cardiovasc J of Southern Africa 1991; 2: 69–71.Google Scholar
5.Baskin, TW, Rosenthal, A, Pruitt, BA. Acute bacterial endocarditis: a silent source ofsepsis in the burn patient. Ann Surg 1976; 184: 618–621.CrossRefGoogle Scholar
6.Chan, P, Ogilby, JD, Segal, B. Tricuspid valve endocarditis. Am Heart J 1989; 117: 1140–1146.CrossRefGoogle ScholarPubMed
7.Levin, S, Schlesinger, M, Handzel, Z, Hahn, T, Altman, Y, Czernobilsky, B, Boss, J. Thymic deficiency in Down's Syndrome. Pediatrics 1979; 63: 80–87.CrossRefGoogle ScholarPubMed
8.Björksten, B, Back, O, Gustavson, KH, Hallmans, G, Hägglöf, B, Tärnvik, A. Zinc and immune function in Down's Syndrome. Acta Pcdiatr Scand 1980; 69: 183–187.CrossRefGoogle ScholarPubMed