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Severe transient neonatal long QT syndrome due to maternal paroxetine usage: a case report

Part of: Electrophysiology

Published online by Cambridge University Press:  02 September 2019

Eeke C. M. Leerssen Open the ORCID record for Eeke C. M. Leerssen [Opens in a new window] ,
Ramon O. Tak  and
Johannes M. P. J. Breur
Eeke C. M. Leerssen
Affiliation:
Department of Paediatric Cardiology, University Medical Centre/Wilhelmina Children’s Hospital, Utrecht, the Netherlands
Ramon O. Tak
Affiliation:
Department of Paediatric Cardiology, University Medical Centre/Wilhelmina Children’s Hospital, Utrecht, the Netherlands
Johannes M. P. J. Breur*
Affiliation:
Department of Paediatric Cardiology, University Medical Centre/Wilhelmina Children’s Hospital, Utrecht, the Netherlands
*
Author for correspondence: J. M. P. J. Breur, Department of Paediatric Cardiology, University Medical Centre/Wilhelmina Children’s Hospital, Lundlaan 6, 3584 Utrecht, the Netherlands. Tel: 088 75 555 55; Fax: 088 75 55 23; E-mail: [email protected]
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Abstract

A female neonate with in utero selective serotonin reuptake inhibitor exposure presented with bradycardia shortly after birth. Electrocardiography showed severe QT prolongation and second-degree atrioventricular block. Over time QT-times spontaneously normalised and genetic testing did not show mutations associated with long QT syndrome making maternal selective serotonin reuptake inhibitor usage the most likely explanation for the observed severe transient neonatal QT prolongation.

Keywords

Long QT syndromeselective serotonin reuptake inhibitorparoxetineneonatein utero exposure
Type
Brief Report
Information
Cardiology in the Young , Volume 29 , Issue 10 , October 2019 , pp. 1300 - 1301
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Copyright
© Cambridge University Press 2019 

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References

Crotti, L, Celano, G, Dagradi, F, Schwartz, P. Congenital long QT syndrome. Orphanet J of Rare Dis 2008 Jul 7; 3: 18.CrossRefGoogle ScholarPubMed
Vincent, GM, Timothy, K, Zhang, L. Congenital long QT syndrome. Card Electrophysiol Rev 2002 Feb; 6: 57–60.CrossRefGoogle ScholarPubMed
Camm, AJ, Malik, M, Yap, YG. Acquired Long QT Syndrome, 1st edn. John Wiley & Sons, London, 2008.Google Scholar
Marzuillo, P, Benettoni, A, Germani, C, Ferrara, G, D′Agata, B, Barbi, E. Acquired long QT syndrome. Pediatr Emerg Care 2014 Apr; 30: 257–261.CrossRefGoogle ScholarPubMed
Dubnov-Raz, G, Juurlink, D, Fogelman, R, et al. Antenatal use of selective serotonin-reuptake inhibitors and QT interval prolongation in newborns. Pediatrics 2008 Sep; 122: e710–e715.CrossRefGoogle ScholarPubMed