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Serum pyridoxine, folate, cobalamin, and homocysteine levels in children presenting with vasovagal syncope

Part of: Basic Science

Published online by Cambridge University Press:  29 July 2021

Tetiana Kovalchuk Open the ORCID record for Tetiana Kovalchuk [Opens in a new window]  and
Oksana Boyarchuk
Tetiana Kovalchuk*
Affiliation:
Department of Pediatrics # 2, Ivan Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
Oksana Boyarchuk
Affiliation:
Department of Pediatrics and Pediatric Surgery, Ivan Horbachevsky Ternopil National Medical University, Ternopil, Ukraine
*
Author for correspondence: Dr. Tetiana Kovalchuk, Department of Pediatrics # 2, Ivan Horbachevsky Ternopil National Medical University, 1, Maydan Voli, Ternopil46001, Ukraine. Tel.: +380672536322. E-mail: [email protected]
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Abstract

Background:

Recent studies confirm the role of B vitamins deficiency and hyperhomocysteinaemia in the development of dysautonomia that has been considered to be the main factor in vasovagal syncope development. The aim of the study was to investigate serum pyridoxine, folate, cobalamin, and homocysteine levels in children presenting with vasovagal syncope and to analyse the correlation between them and main clinical parameters of syncope.

Methods:

We studied 40 children, ages 8–17 years with a history of vasovagal syncope and 24 healthy volunteers. The serum pyridoxine, folate, cobalamin, and homocysteine levels were measured by a quantitative sandwich enzyme immunoassay technique using a commercial kit (Monobind, USA). Twenty-four-hour Holter monitoring and 24-hour ambulatory blood pressure monitoring were conducted for all participated patients.

Results:

Serum pyridoxine (9.42 ± 4.87, 16.11 ± 5.53 µg/L) and cobalamin (307.48 ± 95.50, 447.28 ± 108.85 ng/L) levels were reasonably low (p < 0.05) in patients with vasovagal syncope. Although there was no significant change in folate levels between syncope and healthy children (4.00 ± 1.34, 4.71 ± 1.73 µg/L; p = 0.20), we detected low folate-level association with longer duration of syncope (r = −0.42) and post syncope (r = −0.43) symptoms (p < 0.05). Finally, there was increased serum homocysteine level (13.55 ± 5.03, 7.81 ± 1.71 µmol/L; p < 0.05) in patients with vasovagal syncope. It was positively correlated with the average PQ interval (r = 0.35, p < 0.05) and average QTc interval (r = 0.49, p < 0.05).

Conclusions:

The results suggested that pyridoxine, folate, cobalamin, and homocysteine may be involved in the pathogenesis of vasovagal syncope. This might provide a new approach for effective treatment of paediatric vasovagal syncope, requiring further study.

Keywords

Vasovagal syncopepyridoxinefolatecobalaminhomocysteine
Type
Original Article
Information
Cardiology in the Young , Volume 32 , Issue 5 , May 2022 , pp. 762 - 768
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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