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Risk for prolonged QT interval and associated outcomes in children with early restrictive eating patterns

Published online by Cambridge University Press:  02 June 2015

Karine Guerrier ,
Laurie Mitan ,
Yu Wang  and
Richard J. Czosek
Karine Guerrier*
Affiliation:
Department of Cardiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
Laurie Mitan
Affiliation:
Division of Adolescent and Transition Medicine, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
Yu Wang
Affiliation:
Division of Biostatistics and Epidemiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
Richard J. Czosek
Affiliation:
Department of Cardiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, United States of America
*
Correspondence to: K. Guerrier, DO, MPH, Cincinnati Children’s Hospital Medical Center, 3333 Burnet Avenue, MLC 2003, Cincinnati, OH 45229, United States of America. Tel: +513-636-4432; Fax: +513-636-3952; E-mail: [email protected]
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Abstract

Aim

This study aimed to describe the frequency of QTc prolongation in children with restrictive eating disorders early in the course of disease admitted for inpatient therapy, to determine the frequency of associated ventricular arrhythmia, and to evaluate the relationship between QTc interval and concomitant electrolyte abnormalities and rate of weight loss.

Methods

This was a retrospective cohort study of patients aged 11–25 years with early restrictive eating disorders.

Results

In all, 82 patients met the inclusion criteria (84% female). In total, 9.8% had prolonged QTc interval during hospitalisation. Patients with prolonged QTc had significantly higher resting heart rates (p=0.006), but there was no association with hypokalaemia (p=0.31), hypomagnesaemia (p=0.43), hypophosphataemia (p=1), or rate of weight loss (p=1).

Conclusion

Mild QTc prolongation in patients with restrictive eating disorders is not related to electrolyte abnormalities or rate of weight loss in this population, suggesting that investigation about other potential risk factors of prolonged QTc interval may be warranted.

Keywords

Anorexia nervosaeating disorderprolonged QTrestrictive eatinglong QT
Type
Original Articles
Information
Cardiology in the Young , Volume 26 , Issue 4 , April 2016 , pp. 644 - 649
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Copyright
© Cambridge University Press 2015 

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