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Risk factors for congenital heart defects in two populations residing in the same geographic area: a long-term population-based study, Southern Israel

Published online by Cambridge University Press:  09 July 2019

Renana Robinson ,
Moshe Stavsky ,
Maayan Yitshak Sade ,
Hanah Krymko ,
Leonel Slanovic ,
Victor Novack ,
Maya Atar Vardi ,
Arnon Broides  and
Aviva Levitas
Renana Robinson
Affiliation:
Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Moshe Stavsky
Affiliation:
Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel Soroka Clinical Research Center, Soroka University Medical Center, Beer-Sheva, Israel
Maayan Yitshak Sade
Affiliation:
Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel Soroka Clinical Research Center, Soroka University Medical Center, Beer-Sheva, Israel
Hanah Krymko
Affiliation:
Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel Department of Pediatric Cardiology, Soroka University Medical Center, Beer-Sheva, Israel
Leonel Slanovic
Affiliation:
Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel Department of Pediatric Cardiology, Soroka University Medical Center, Beer-Sheva, Israel
Victor Novack
Affiliation:
Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel Soroka Clinical Research Center, Soroka University Medical Center, Beer-Sheva, Israel
Maya Atar Vardi
Affiliation:
Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
Arnon Broides*
Affiliation:
Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel Pediatric Division, Soroka University Medical Center, Beer-Sheva, Israel
Aviva Levitas
Affiliation:
Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel Department of Pediatric Cardiology, Soroka University Medical Center, Beer-Sheva, Israel
*
Author for correspondence: Arnon Broides M.D., Department of Pediatric Cardiology, Soroka University Medical Center, Beer-Sheva, Israel, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel, Tel: +972-54-236-5205. E-mail: [email protected]
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Abstract

Background:

Congenital Heart Defects (CHD) are the most common structural defects of newborns. Southern Israel’s population is comprised of Jews (75%) and Arab-Bedouins (25%). The latter has a high rate of consanguinity and low abortion rate compared with the Jewish population, which led us to suspect a higher CHD prevalence in this population. Our aim was to compare maternal risk factors that are associated with CHD in these populations.

Methods:

All births during 1991–2011 in Soroka University Medical Center (n = 247, 289) with 6078 newborns having CHD were included. To account for same-woman deliveries, general estimating equation models adjusted for ethnicity, gender and birth number were used.

Results:

The total prevalence of CHD was 24.6/1000 live births, with 21.4 and 30 among Jewish and Bedouin populations, respectively, (p = 0.001). Multi-variant analysis of risk factors for CHD revealed that risk factors common to both populations included conception with fertility medications, sibling CHD, maternal CHD, diabetes mellitus, hypertension and anaemia. Risk factors that were specific for the Bedouin population were – maternal age over 35 years, recurrent pregnancy loss and in vitro fertilisation. However, sibling CHD was more common as a CHD risk factor in the Jewish compared with the Bedouin population (Adjusted OR 10.23 versus 3.19, respectively).

Conclusions:

The prevalence of CHD is higher in both the Bedouin and Jewish populations than previously reported. Several maternal factors were associated with CHD specifically for a certain population. Risk factors for CHD vary in populations residing in the same geographic area.

Keywords

Congenital heart defectsBedouinmaternal-foetal relationsepidemiology
Type
Original Article
Information
Cardiology in the Young , Volume 29 , Issue 8 , August 2019 , pp. 1040 - 1044
Copyright
© Cambridge University Press 2019 

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