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Regional differnces in birth prevalence of congenital heart disease in Malta

Published online by Cambridge University Press:  19 August 2008

Victor Grech ,
Hugo Agius-Muscat ,
Charles Savona-Ventura  and
Joe Pace
Victor Grech*
Affiliation:
St Luke's Hospital, Guardamangia, Department of Health Information, Malta
Hugo Agius-Muscat
Affiliation:
St Luke's Hospital, Guardamangia, Department of Health Information, Malta
Charles Savona-Ventura
Affiliation:
St Luke's Hospital, Guardamangia, Department of Health Information, Malta
Joe Pace
Affiliation:
St Luke's Hospital, Guardamangia, Department of Health Information, Malta
*
Dr Victor Grech, Paediatric Department, St Luke's Hospital, Guardamangia, Malta. Tel: 241251 Ext. 1471; Fax: 240176; email: [email protected]
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Abstract

Aim

Recent studies have shown a correlation between environmental pollutants and increased risk of selected congenital malformations. The South-East area of the Island of Malta is much more industrialised than the more rural North-West area. The aim of this study was to test the null hypothesis that there are no regional differences in Malta in the prevalence at birth of congenital cardiac malformations. Methods: Live born infants with congenital cardiac malformations born between 1990 and 1994 were allocated to 10 areas, and thence to 2 regions of 5 areas each, so as to constitute North-West and South-East Malta. Official publications gave population totals and growth rates. Those infants with congenital cardiac malformations were then compared between the different regions using χ2 and the Mann-Whitney U test.

Results

The overall prevalence of congenital heart disease at birth was 8.8/1000 live births. The birth prevalence for the South-East region (10.1/1000 LB – 95% CI 8.4–12.3/1000 live births) was significantly higher than for the North-West (7.4/1000 live births – 95% CI 6.0–9.0/1000 live births) – p=0.03, Odds ratio 1.38 (95% CI 1.05–2.61). The Mann-Whitney U test showed a significant difference in the distribution amongst the 10 defined areas (p=0.016). The Central-East area had the highest prevalence of cardiac malformations in the entire Island – p=0.02, Odds ratio 1.70 (95% CI 1.10–2.61). Demography showed an efflux of individuals from the South-East of Malta.

Conclusion

The higher prevalence of congenital heart disease noted at birth in South-East Malta is unlikely to be due to genetic factors, as these would have migrated North-West along with the population movement. An environmental factor, therefore, seems more likely to be responsible for the increased predisposition to congenital heart disease in the South-East of Malta.

Keywords

Heart defects-congenitalheart defects-congenital-epidemiologyresidence characteristicspregnancy
Type
Original Articles
Information
Cardiology in the Young , Volume 9 , Issue 2 , March 1999 , pp. 150 - 154
Copyright
Copyright © Cambridge University Press 1999

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