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Quantitative assessment of the association between IL-10 -592 A/C polymorphism and Kawasaki disease risk in Chinese population: evidence from a meta-analysis

Published online by Cambridge University Press:  16 April 2018

Xiaochun Jin ,
Shuzhou Yin ,
Youtao Zhang  and
Xu Chen
Xiaochun Jin
Affiliation:
Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, People’s Republic of China
Shuzhou Yin
Affiliation:
Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou, People’s Republic of China
Youtao Zhang
Affiliation:
Department of Clinical Laboratory, First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
Xu Chen*
Affiliation:
Department of Clinical Laboratory, First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China
*
Author for correspondence: X. Chen, Department of Clinical Laboratory, First Affiliated Hospital of Soochow University, 188 Shizi Road, Suzhou 215006, People’s Republic of China. Tel: +86 139 1359 4769; Fax: +86 139 1359 4769; E-mail: [email protected]
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Abstract

Background

IL-10, as a proinflammatory and anti-inflammatory cytokine, has been thought to have an important role in the development of Kawasaki disease. Variation in the IL-10 gene might lead to altered protein production, which may result in Kawasaki disease. Several studies have been performed to investigate the IL-10 -592 A/C polymorphism and Kawasaki disease risk. Unfortunately, the results of previous studies were inconsistent. Therefore, we performed a meta-analysis to derive a more precise estimation of the association between the IL-10 -592 A/C polymorphism and Kawasaki disease risk.

Method

The association between the IL-10 -592 A/C polymorphism and Kawasaki disease risk was assessed by odds ratios (ORs) together with their 95% confidence intervals (CIs). Six studies were enrolled in the present meta-analysis.

Results

Overall, no significant association between IL-10 -592 A/C polymorphism and Kawasaki disease risk was found under allele contrast (A versus C: OR=0.95, 95% CI=0.77–1.18, p=0.668), homozygote comparison (AA versus CC: OR=0.86, 95% CI=0.56–1.31, p=0.475), heterozygote comparison (CA versus CC: OR=0.88, 95% CI=0.65–1.19, p=0.479), recessive genetic model (AA versus CA/CC: OR=0.96, 95% CI=0.73–1.28, p=0.801), or dominant genetic model (AA/CA versus CC: OR=0.85, 95% CI=0.64–1.13, p=0.275).

Conclusions

We conclude that IL-10 -592 A/C polymorphism was not associated with Kawasaki disease risk in the Chinese population. However, more primary large-scale and well-designed studies are still required to further evaluate the interaction of IL-10 -592 A/C polymorphism with Kawasaki disease risk.

Keywords

Interleukin-10polymorphismKawasaki diseaseinflammationmeta-analysis
Type
Original Articles
Information
Cardiology in the Young , Volume 28 , Issue 6 , June 2018 , pp. 811 - 815
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Copyright
© Cambridge University Press 2018 

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References

1. Burgner, D, Harnden, A. Kawasaki disease: what is the epidemiology telling us about the etiology? Int J Infect Dis 2005; 9: 185–194.Google Scholar
2. Fujita, Y, Nakamura, Y, Sakata, K, et al. Kawasaki disease in families. Pediatrics 1989; 84: 666–669.Google Scholar
3. Kim, DS, Lee, HK, Noh, GW, Lee, SI, Lee, KY. Increased serum interleukin-10 level in Kawasaki disease. Yonsei Med J 1996; 37: 125–130.Google Scholar
4. Lin, CY, Lin, CC, Hwang, B, Chiang, B. Serial changes of serum interleukin-6, interleukin-8, and tumor necrosis factor alpha among patients with Kawasaki disease. J Pediatr 1992; 121: 924–926.CrossRefGoogle ScholarPubMed
5. Maury, CP, Salo, E, Pelkonen, P. Circulating interleukin-1 beta in patients with Kawasaki disease. New Engl J Med 1988; 319: 1670–1671.Google ScholarPubMed
6. Tsukahara, H, Hiraoka, M, Saito, M, et al. Methylenetetrahydrofolate reductase polymorphism in Kawasaki disease. Pediatr Int 2000; 42: 236–240.CrossRefGoogle ScholarPubMed
7. Hirao, J, Hibi, S, Andoh, T, Ichimura, T. High levels of circulating interleukin-4 and interleukin-10 in Kawasaki disease. Int Arch Allergy Immunol 1997; 112: 152–156.Google Scholar
8. Noh, GW, Lee, WG, Lee, W, Lee, K. Effects of intravenous immunoglobulin on plasma interleukin-10 levels in Kawasaki disease. Immunology Letters 1998; 62: 19–24.Google Scholar
9. Higgins, JP, Thompson, SG. Quantifying heterogeneity in a meta-analysis. Stat Med 2002; 21: 1539–1558.Google Scholar
10. Mantel, N, Haenszel, W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 1959; 22: 719–748.Google Scholar
11. DerSimonian, R, Laird, N. Meta-analysis in clinical trials. Control Clin Trials 1986; 7: 177–188.Google Scholar
12. Begg, CB, Mazumdar, M. Operating characteristics of a rank correlation test for publication bias. Biometrics 1994; 50: 1088–1101.Google Scholar
13. Yang, J, Li, CR, Li, YB, et al. [The correlation between Kawasaki disease and polymorphisms of Tumor necrosis factor alpha and interleukin-10 gene promoter]. Zhonghua Er Ke Za Zhi 2003; 41: 598–602.Google ScholarPubMed
14. Hsueh, KC, Lin, YJ, Chang, JS, et al. Association of interleukin-10 A-592C polymorphism in Taiwanese children with Kawasaki disease. J Korean Med Sci 2009; 24: 438–442.Google Scholar
15. Weng, KP, Hsieh, KS, Hwang, YT, et al. IL-10 polymorphisms are associated with coronary artery lesions in acute stage of Kawasaki disease. Circ J 2010; 74: 983–989.Google Scholar
16. Weng, KP, Ho, TY, Chiao, YH, et al. Cytokine genetic polymorphisms and susceptibility to Kawasaki disease in Taiwanese children. Circ Journal 2010; 74: 2726–2733.CrossRefGoogle ScholarPubMed
17. Hsieh, KS, Lai, TJ, Hwang, YT, et al. IL-10 promoter genetic polymorphisms and risk of Kawasaki disease in Taiwan. Dis Markers 2011; 30: 51–59.Google Scholar
18. Lin, YJ, Lan, YC, Lai, CH, et al. Association of promoter genetic variants in interleukin-10 and Kawasaki disease with coronary artery aneurysms. J Clin Lab Anal 2014; 28: 461–464.Google Scholar
19. Kuo, HC, Yang, KD, Juo, SH, et al. ITPKC single nucleotide polymorphism associated with the Kawasaki disease in a Taiwanese population. PLoS One 2011; 6: e17370.Google Scholar
20. Arj-Ong, S, Thakkinstian, A, McEvoy, M, Attia, J. A systematic review and meta-analysis of tumor necrosis factor alpha-308 polymorphism and Kawasaki disease. Pediatr Int 2010; 52: 527–532.Google Scholar
21. Lou, J, Xu, S, Zou, L, et al. A functional polymorphism, rs28493229, in ITPKC and risk of Kawasaki disease: an integrated meta-analysis. Mol Biol Rep 2012; 39: 11137–11144.Google Scholar
22. Xing, Y, Wang, H, Liu, X, et al. Meta-analysis of the relationship between single nucleotide polymorphism rs72689236 of caspase-3 and Kawasaki disease. Mol Biol Rep 2014; 41: 6377–6381.CrossRefGoogle ScholarPubMed