Hostname: page-component-cd9895bd7-fscjk Total loading time: 0 Render date: 2024-12-27T08:53:58.739Z Has data issue: false hasContentIssue false
  • English
  • Français

QT dispersion in childhood obstructive sleep apnoea syndrome

Published online by Cambridge University Press:  12 November 2010

Anant Khositseth ,
Palinee Nantarakchaikul ,
Teeradej Kuptanon  and
Aroonwan Preutthipan
Anant Khositseth*
Affiliation:
Faculty of Medicine, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Palinee Nantarakchaikul
Affiliation:
Faculty of Medicine, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Teeradej Kuptanon
Affiliation:
Faculty of Medicine, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
Aroonwan Preutthipan
Affiliation:
Faculty of Medicine, Department of Pediatrics, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
*
Correspondence to: Dr A. Khositseth, Faculty of Medicine, Department of Pediatrics, Ramathibodi Hospital, 270 Rama VI, Ratchathevee, Bangkok 10400, Thailand. Tel: 662 201 1685; Fax: 662 201 1850; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

The difference between maximal and minimal QT interval and corrected QT interval defined as QT dispersion and corrected QT dispersion may represent arrhythmogenic risks. This study sought to evaluate QT dispersion and corrected QT dispersion in childhood obstructive sleep apnoea syndrome. Forty-four children (34 male) with obstructive sleep apnoea syndrome, aged 6.2 plus or minus 3.5 years along with 38 healthy children (25 male), 6.6 plus or minus 2.1 years underwent electrocardiography to measure QT and RR intervals. Means QT dispersion and corrected QT dispersion were significantly higher in obstructive sleep apnoea syndrome than controls, 52 plus or minus 27 compared to 40 plus or minus 14 milliseconds (p equal to 0.014), and 71 plus or minus 29 compared to 57 plus or minus 19 milliseconds (p equal to 0.010), respectively. Interestingly, QT dispersion and corrected QT dispersion in obstructive sleep apnoea syndrome with obesity, 57 plus or minus 30 and 73 plus or minus 31 milliseconds, were significantly higher than in control, 40 plus or minus 14 and 57 plus or minus 19 milliseconds (p equal to 0.009 and 0.043, respectively). However, QT dispersion and corrected QT dispersion in obstructive sleep apnoea syndrome without obesity, 43 plus or minus 20 and 68 plus or minus 26 milliseconds, were not significantly different. In conclusion, QT dispersion and corrected QT dispersion were significantly increased only in childhood obstructive sleep apnoea syndrome with obesity. Obesity may be the factor affecting the increased QT dispersion and corrected QT dispersion.

Keywords

Electrocardiographychildrenarrhythmia
Type
Original Articles
Information
Cardiology in the Young , Volume 21 , Issue 2 , April 2011 , pp. 130 - 135
Copyright
Copyright © Cambridge University Press 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1.Standards and indications for cardiopulmonary sleep studies in children. American Thoracic Society. Am J Respir Crit Care Med 1996; 153: 866–878.CrossRefGoogle Scholar
2. Au, CT, Li, AM. Obstructive sleep breathing disorders. Pediatr Clin North Am 2009; 56: 243–259.CrossRefGoogle ScholarPubMed
3. Lumeng, JC, Chervin, RD. Epidemiology of pediatric obstructive sleep apnea. Proc Am Thorac Soc 2008; 5: 242–252.CrossRefGoogle ScholarPubMed
4. Bhattacharjee, R, Kheirandish-Gozal, L, Pillar, G, Gozal, D. Cardiovascular complications of obstructive sleep apnea syndrome: evidence from children. Prog Cardiovasc Dis 2009; 51: 416–433.CrossRefGoogle ScholarPubMed
5. Malik, M, Batchvarov, VN. Measurement, interpretation and clinical potential of QT dispersion. J Am Coll Cardiol 2000; 36: 1749–1766.CrossRefGoogle ScholarPubMed
6. Nakamura, T, Chin, K, Hosokawa, R, et al. Corrected QT dispersion and cardiac sympathetic function in patients with obstructive sleep apnea-hypopnea syndrome. Chest 2004; 125: 2107–2114.CrossRefGoogle ScholarPubMed
7. Dursunoglu, D, Dursunoglu, N. Effect of CPAP on QT interval dispersion in obstructive sleep apnea patients without hypertension. Sleep Med 2007; 8: 478–483.CrossRefGoogle ScholarPubMed
8. Dursunoglu, D, Dursunoglu, N, Evrengul, H, et al. QT interval dispersion in obstructive sleep apnoea syndrome patients without hypertension. Eur Respir J 2005; 25: 677–681.CrossRefGoogle ScholarPubMed
9. Ozmen, N, Cebeci, BS, Kardesoglu, E, et al. QT dispersion in non-apneic simple snoring patients and the effect of surgical therapy on QT dispersion. Int J Cardiol 2006; 113: 82–85.CrossRefGoogle ScholarPubMed
10. Brouillette, RT, Morielli, A, Leimanis, A, Waters, KA, Luciano, R, Ducharme, FM. Nocturnal pulse oximetry as an abbreviated testing modality for pediatric obstructive sleep apnea. Pediatrics 2000; 105: 405–412.CrossRefGoogle ScholarPubMed
11. Lattimore, JD, Celermajer, DS, Wilcox, I. Obstructive sleep apnea and cardiovascular disease. J Am Coll Cardiol 2003; 41: 1429–1437.CrossRefGoogle ScholarPubMed
12. Dursunoglu, D, Dursunoglu, N. Cardiovascular diseases in obstructive sleep apnea. Tuberk Toraks 2006; 54: 382–396.Google ScholarPubMed
13. Flemons, WW, Remmers, JE, Gillis, AM. Sleep apnea and cardiac arrhythmias. Is there a relationship? Am Rev Respir Dis 1993; 148: 618–621.CrossRefGoogle ScholarPubMed
14. Hoffstein, V, Mateika, S. Cardiac arrhythmias, snoring, and sleep apnea. Chest 1994; 106: 466–471.CrossRefGoogle ScholarPubMed
15. Javaheri, S, Parker, TJ, Liming, JD, et al. Sleep apnea in81 ambulatory male patients with stable heart failure. Types and their prevalences, consequences, and presentations. Circulation 1998; 97: 2154–2159.CrossRefGoogle Scholar
16. Zabel, M, Klingenheben, T, Franz, MR, Hohnloser, SH. Assessment of QT dispersion for prediction of mortality or arrhythmic events after myocardial infarction: results of a prospective, long-term follow-up study. Circulation 1998; 97: 2543–2550.CrossRefGoogle ScholarPubMed
17. Merx, W, Yoon, MS, Han, J. The role of local disparity in conduction and recovery time on ventricular vulnerability to fibrillation. Am Heart J 1977; 94: 603–610.CrossRefGoogle ScholarPubMed
18. Seyfeli, E, Duru, M, Kuvandik, G, Kaya, H, Yalcin, F. Effect of weight loss on QTc dispersion in obese subjects. Anadolu Kardiyol Derg 2006; 6: 126–129.Google ScholarPubMed
19. Seyfeli, E, Duru, M, Kuvandik, G, Kaya, H, Yalcin, F. Effect of obesity on P-wave dispersion and QT dispersion in women. Int J Obes (Lond) 2006; 30: 957–961.CrossRefGoogle ScholarPubMed
20. Capdevila, OS, Kheirandish-Gozal, L, Dayyat, E, Gozal, D. Pediatric obstructive sleep apnea: complications, management, and long-term outcomes. Proc Am Thorac Soc 2008; 5: 274–282.CrossRefGoogle ScholarPubMed