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QT dispersion and cardiac involvement in children with Familial Mediterranean fever

Published online by Cambridge University Press:  09 November 2011

Bülent Koca ,
Özgür Kasapçopur ,
Süleyman Bakari ,
Emine Sönmez ,
Funda Öztunç ,
Ayşe Güler Eroğlu ,
Levent Saltik  and
Özden Calay
Bülent Koca*
Affiliation:
Department of Pediatric Cardiology, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey
Özgür Kasapçopur
Affiliation:
Department of Pediatric Rheumatology, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey
Süleyman Bakari
Affiliation:
Department of Pediatric Cardiology, Vivo Medical Center, Istanbul, Turkey
Emine Sönmez
Affiliation:
Department of Pediatrics, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey
Funda Öztunç
Affiliation:
Department of Pediatric Cardiology, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey
Ayşe Güler Eroğlu
Affiliation:
Department of Pediatric Cardiology, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey
Levent Saltik
Affiliation:
Department of Pediatric Cardiology, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey
Özden Calay
Affiliation:
Department of Biostatistics, Cerrahpasa Medical Faculty, İstanbul University, Istanbul, Turkey
*
Correspondence to: Dr B. Koca, MD, Department of Pediatric Cardiology, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey. Tel: +90 212 4143000; Fax: +90 212 632 86 33; E-mail: [email protected]
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Abstract

Familial Mediterranean fever is a hereditary disease characterised by recurrent and self-terminated attacks of fever and polyserositis. An earlier study found that adult patients of Familial Mediterranean fever had an abnormally longer QT dispersion and corrected QT dispersion, markers for ventricular arrhythmogenicity. QT dispersion is a simple non-invasive arrhythmogenic marker that can be used to assess homogeneity of cardiac repolarisation; however, it has not been studied in children with Familial Mediterranean fever before. The aim of this study was to assess QT dispersion and corrected QT dispersion, and their relationship with systolic and diastolic function of the left ventricle in a group of children with Familial Mediterranean fever. We performed electrocardiography and Doppler echocardiography on patients and controls. Maximum QT, minimum QT, QT dispersion, corrected QT, maximum corrected QT, minimum corrected QT, and corrected QT dispersion intervals were measured from standard 12-lead electrocardiography. No statistically significant differences were found between the groups in QT dispersion, corrected QT dispersion, and systolic–diastolic function of the left ventricle parameters. During the 12 months of follow-up, no ventricular arrhythmias were documented in either group.

Keywords

Familial Mediterranean feverQT dispersionelectrocardiographyarrhythmiaechocardiographydiastolic dysfunction
Type
Original Article
Information
Cardiology in the Young , Volume 22 , Issue 4 , August 2012 , pp. 404 - 409
Copyright
Copyright © Cambridge University Press 2012

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References

1. Kuo, CS, Munokata, K, Reddy, CP, Surawicz, B. Characteristics and possible mechanism of ventricular arrhythmia dependent on the dispersion of action potential durations. Circulation 1983; 67: 1356–1367.CrossRefGoogle ScholarPubMed
2. Fei, L, Statters, DJ, Camm, AJ. QT interval dispersion on 12-lead electrocardiogram in normal subjects: its reproducibility and relation to the T wave. Am Heart J 1994; 127: 1654–1655.CrossRefGoogle Scholar
3. Higham, PD, Campbell, RW. QT dispersion. Br Heart J 1994; 71: 508–510.CrossRefGoogle ScholarPubMed
4. Akcay, A, Acar, G, Sayarlioglu, M, et al. QT dispersion and transmural dispersion of repolarization in patients with familial Mediterranean fever. Mod Rheumatol 2009; 19: 550–555.CrossRefGoogle ScholarPubMed
5. Cindas, A, Kutsal, YG, Tokgözoglu, L, Karanfil, A. QT dispersion and cardiac involvement in patients with rheumatoid arthritis. Scand J Rheumatol 2002; 31: 22–26.CrossRefGoogle ScholarPubMed
6. Yildirir, A, Aksoyek, S, Calguneri, M, et al. QT dispersion as a predictor of arrhythmic events in patients with ankylosing spondylitis. Rheumatology 2000; 38: 875–879.CrossRefGoogle Scholar
7. Yavuz, B, Atalar, E, Karadag, O, et al. QT dispersion increases in patients with systemic lupus erythematosus. Clin Rheumatol 2007; 26: 376–379.CrossRefGoogle ScholarPubMed
8. Livneh, A, Langevitz, P, Zemer, D, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum 1997; 40: 1879–1885.CrossRefGoogle ScholarPubMed
9. Sahn, DJ, Demaria, A, Kisslo, J, Weyman, A. Recommendation regarding quantification in M-mode echocardiography: results of survey of echocardiographic measurement. Circulation 1978; 58: 1072–1083.CrossRefGoogle Scholar
10. Devereux, RB, Alonso, DR, Lutas, EM, et al. Echocardiographic assessment of left ventricular hypertrophy: comparison to necropsy findings. Am J Cardiol 1986; 57: 450–458.CrossRefGoogle ScholarPubMed
11. Myreng, Y, Smiseth, OA. Assessment of left ventricular relaxation by Doppler echocardiography. Circulation 1990; 81: 260–266.CrossRefGoogle ScholarPubMed
12. Bazett, HC. An analysis of the time relations of electrocardiograms. Heart 1920; 7: 353–355.Google Scholar
13. Bilginer, Y, Ozaltın, F, Basaran, C, et al. Evaluation of intima media thickness of the common and internal carotid arteries with inflammatory markers in familial Mediterranean fever as possible predictors for atherosclerosis. Rheumatol Int 2008; 28: 1211–1216.CrossRefGoogle ScholarPubMed
14. Wislowska, M, Jaszczyk, B, Kochmanski, M, Sypula, S, Sztechman, M. Diastolic heart function in RA patients. Rheumatol Int 2008; 28: 513–519.CrossRefGoogle ScholarPubMed
15. Achong, N, Wahi, S, Marwick, TH. Evaluation and outcome of diastolic dysfunction. Heart 2009; 95: 813–818.CrossRefGoogle Scholar
16. Sarı, I, Arican, O, Can, G, et al. Assessment of aortic stiffness and ventricular functions in familial Mediterranean fever. Anadolu Kardiyol Derg 2008; 8: 271–278.Google ScholarPubMed
17. Caliskan, M, Gullu, H, Yilmaz, S, et al. Impaired coronary microvascular function in FMF. Atherosclerosis 2007; 195: 161–167.CrossRefGoogle Scholar
18. Akdogan, A, Calguneri, M, Yavuz, B, et al. Are familial Mediterranean fever patients at increased risk for atherosclerosis? Impaired endothelial function and increased intima media thickness are found in familial Mediterranean fever. J Am Coll Cardiol 2006; 48: 2351–2353.CrossRefGoogle ScholarPubMed
19. Nussinovitch, N, Livneh, A, Katz, K, et al. QT dispersion in uncomplicated familial Mediterranean fever. Clin Rheumatol 2010; 29: 1353–1356.CrossRefGoogle ScholarPubMed
20. Langevitz, P, Livneh, A, Neumann, L, et al. Prevalence of ischemic heart disease in patients with familial Mediterranean fever. Isr Med Assoc J 2001; 3: 9–12.Google ScholarPubMed
21. Murray, A, Mclaughlin, NB, Campbell, RW. Measuring QT dispersion: man versus machine. Heart 1997; 77: 539–542.CrossRefGoogle ScholarPubMed
22. Gasparyan, AY, Ugurlucan, M. The emerging issue of cardiovascular involvement in familial Mediterranean fever. Arch Med Sci 2008; 4: 465–467.Google Scholar
23. Yuksel, S, Ayvazyan, L, Gasparyan, AY. Familial Mediterranean fever as an emerging clinical model of atherogenesis associated with low-grade inflammation. Open Cardiovasc Med J 2010; 4: 51–56.Google ScholarPubMed
24. Nussinovitch, N, Livneh, A, Katz, K, et al. Heart rate variability in familial Mediterranean fever. Rheumatol Int 2011; 31: 39–43.CrossRefGoogle ScholarPubMed
25. Kumar, N, Rasheed, K, Gallo, R, Al-Hales, Z, Duran, CM. Rheumatic involvement of all four heart valves: preoperative echocardiographic diagnosis and successful surgical management. Eur J Cardiothorac Surg 1995; 9: 713–714.CrossRefGoogle ScholarPubMed