Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-18T15:56:07.337Z Has data issue: false hasContentIssue false

Prolonged length of stay after surgery for adult congenital heart disease: a single-centre study in a developing country

Published online by Cambridge University Press:  15 July 2020

Russell S. Martins
Affiliation:
Medical College, Aga Khan University Hospital, Karachi74800, Pakistan
Zaiba S. Dawood
Affiliation:
Medical College, Aga Khan University Hospital, Karachi74800, Pakistan
Muhammad K. Y. Memon
Affiliation:
Department of Pediatrics, Liaquat National Hospital & Medical College, Karachi74800, Pakistan
Saleem Akhtar*
Affiliation:
Department of Pediatrics and Child Health, Aga Khan University Hospital, Karachi74800, Pakistan
*
Author for correspondence: Saleem Akhtar, Department of Pediatrics and Child Health, Aga Khan University Hospital, Stadium Road, Karachi74800, Pakistan. Tel: +92-307-2393757. E-mail: [email protected]

Abstract

Background:

With the growing number of adults requiring operations for CHD, prolonged length of stay adds an additional burden on healthcare systems, especially in developing countries. This study aimed to identify factors associated with prolonged length of stay in adult patients undergoing operations for CHD.

Methods:

This retrospective study included all adult patients (≥18 years) who underwent cardiac surgery with cardiopulmonary bypass for their CHD from 2011 to 2016 at a tertiary-care private hospital in Pakistan. Prolonged length of stay was defined as hospital stay >75th percentile of the overall cohort (>8 days).

Results:

This study included 166 patients (53.6% males) with a mean age of 32.05 ± 12.11 years. Comorbid disease was present in 59.0% of patients. Most patients underwent atrial septal defect repair (42.2%). A total of 38 (22.9%) patients had a prolonged length of stay. Post-operative complications occurred in 38.6% of patients. Multivariable analysis showed that pre-operative body mass index (odds ratio: 0.779; 95% confidence interval: 0.620–0.980), intraoperative aortic cross-clamp time (odds ratio: 1.035; 95% confidence interval: 1.009–1.062), and post-operative acute kidney injury (odds ratio: 7.392; 95% confidence interval: 1.036–52.755) were associated with prolonged length of stay.

Conclusion:

Predictors of prolonged length of stay include lower body mass index, longer aortic cross-clamp time, and development of post-operative acute kidney injury. Shorter operations, improved pre-operative nutritional optimisation, and timely management of post-operative complications could help prevent prolonged length of stay in patients undergoing operations for adult CHD.

Type
Original Article
Copyright
© The Author(s), 2020. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Warnes, CA.Adult congenital heart disease: the challenges of a lifetime. Eur Heart J 2017; 38: 20412047.Google ScholarPubMed
Moodie, D.Adult congenital heart disease: past, present, and future. Tex Heart Inst J 2011; 38: 705706.Google ScholarPubMed
Brida, M, Gatzoulis, MA.Adult congenital heart disease: past, present, future. Acta Paediatr 2019; 108: 17571764.CrossRefGoogle Scholar
Shahabuddin, S, Hashmi, S, Rakhshan, E, Khan, JK, Sami, SA, Amanullah, M.Is Grown Up Congenital Heart (GUCH) disease different in a developing country? JPMA 2016; 66: S-5.Google ScholarPubMed
Gnanappa, GK, Ganigara, M, Prabhu, A, et al.Outcome of complex adult congenital heart surgery in the developing world. Congenit Heart Dis 2011; 6: 28.CrossRefGoogle ScholarPubMed
Mello, GAd, Carvalho, JL, Baucia, JA, Magalhaes Filho, J. Adults with congenital heart disease undergoing first surgery: prevalence and outcomes at a tertiary hospital. Braz J Cardiov Surg 2012; 27: 529534.CrossRefGoogle ScholarPubMed
Kempny, A, Dimopoulos, K, Uebing, A, et al.Outcome of cardiac surgery in patients with congenital heart disease in England between 1997 and 2015. PloS One 2017; 12: e0178963.CrossRefGoogle ScholarPubMed
Kogon, B, Grudziak, J, Sahu, A, et al.Surgery in adults with congenital heart disease: risk factors for morbidity and mortality. Ann Thorac Surg 2013; 95: 13771382.CrossRefGoogle ScholarPubMed
Cedars, A, Benjamin, L, Burns, SV, Novak, E, Amin, A.Clinical predictors of length of stay in adults with congenital heart disease. Heart 2017; 103: 12581263.CrossRefGoogle ScholarPubMed
Romano, PS, Hussey, P, Ritley, D.Selecting Quality and Resource Use Measures: A Decision Guide for Community Quality Collaboratives. Rockville, MD: US Department of Health and Human Services, Agency for Healthcare Research, 2010.Google Scholar
Thomas, JW, Guire, KE, Horvat, GG.Is patient length of stay related to quality of care? J Healthc Manag 1997; 42: 489.Google ScholarPubMed
Kalish, RL, Daley, J, Duncan, CC, Davis, RB, Coffman, GA, Iezzoni, LI.Costs of potential complications of care for major surgery patients. Am J Med Qual 1995; 10: 4854.CrossRefGoogle ScholarPubMed
al-Haddad, BJ, Menk, JS, Kochilas, L, Vinocur, JM. Factors affecting length of postoperative hospitalization for pediatric cardiac operations in a large North American registry (1982–2007). Pediatr Cardiol 2016; 37: 884891.CrossRefGoogle Scholar
Mercer-Rosa, L, Elci, OU, DeCost, G, et al.Predictors of length of hospital stay after complete repair for tetralogy of Fallot: a prospective cohort study. J Am Heart Assoc 2018; 7: e008719.CrossRefGoogle ScholarPubMed
World Health Organization, Regional Office for the Western Pacific. The Asia-Pacific perspective: redefining obesity and its treatment. Sydney: Health Communications Australia, 2000.Google Scholar
Jenkins, KJ, Gauvreau, K, Newburger, JW, Spray, TL, Moller, JH, Iezzoni, LI.Consensus-based method for risk adjustment for surgery for congenital heart disease. J Thorac Cardiovasc Surg 2002; 123: 110118.CrossRefGoogle ScholarPubMed
Dyke, C, Aronson, S, Dietrich, W, et al.Universal definition of perioperative bleeding in adult cardiac surgery. J Thorac Cardiovasc Surg, 2014; 147: 14581463.CrossRefGoogle ScholarPubMed
Kidney Disease: Improving Global Outcomes (KDIGO) Acute Kidney Injury Work Group. KDIGO clinical practice guideline for acute kidney injury. Kidney Int Suppl 2012; 2: 1138.Google Scholar
Krell, RW, Girotti, ME, Dimick, JB.Extended length of stay after surgery: complications, inefficient practice, or sick patients? JAMA Surg 2014; 149: 815820.CrossRefGoogle ScholarPubMed
Kwiatkowski, DM, Price, E, Axelrod, DM, et al.Incidence, risk factors, and outcomes of acute kidney injury in adults undergoing surgery for congenital heart disease. Cardiol Young 2017; 27: 10681075.CrossRefGoogle ScholarPubMed
van Gameren, M, Putman, LM, Takkenberg, JJ, Bogers, AJ.Risk stratification for adult congenital heart surgery. Eur J Cardiothorac Surg 2011; 39: 490494.CrossRefGoogle ScholarPubMed
Bhatt, AB, Rajabali, A, He, W, Benavidez, OJ.High resource use among adult congenital heart surgery admissions in adult hospitals: risk factors and association with death and comorbidities. Congenit Heart Dis 2015; 10: 1320.CrossRefGoogle ScholarPubMed
Bode-Thomas, F.Challenges in the management of congenital heart disease in developing countries. In: Congenital Heart Disease -Selected Aspects, InTechOpen, 2012: 263272. ISBN: 978-953-307-472-6. Retrieved from https://www.intechopen.com/books/congenital-heart-disease-selected-aspects/challenges-in-the-management-of-congenital-heart-disease-in-developing-countriesCrossRefGoogle Scholar
Saxena, A.Adult with congenital heart disease in developing country: scope, challenges and possible solutions. Curr Treat Options Cardiovasc Med 2015; 17: 46.CrossRefGoogle ScholarPubMed
Mariscalco, G, Lorusso, R, Dominici, C, Renzulli, A, Sala, A.Acute kidney injury: a relevant complication after cardiac surgery. Ann Thorac Surg 2011; 92: 15391547.CrossRefGoogle ScholarPubMed
Dasta, JF, Kane-Gill, SL, Durtschi, AJ, Pathak, DS, Kellum, JA.Costs and outcomes of acute kidney injury (AKI) following cardiac surgery. Nephrol Dial Transpl 2008; 23: 19701974.CrossRefGoogle ScholarPubMed
Cedars, A, Benjamin, L, Burns, SV, Novak, E, Amin, A.Clinical predictors of length of stay in adults with congenital heart disease. Heart (British Cardiac Society). 2017; 103: 12581263.Google ScholarPubMed
Fuhrman, DY, Nguyen, LG, Sanchez-de-Toledo, J, Priyanka, P, Kellum, JA.Postoperative acute kidney injury in young adults with congenital heart disease. Ann Thorac Surg 2019; 107: 14161420.CrossRefGoogle ScholarPubMed
Memon, MKY, Akhtar, S, Martins, RS, Ahmed, R, Saeed, A, Shaheen, F.Adult congenital heart disease: frequency, risk factors and outcomes of acute kidney injury in postoperative period. Indian J Thorac Cardiovasc Surg 2020; 36: 365372.CrossRefGoogle Scholar
Peitz, GW, Troyer, J, Jones, AE, et al.Association of body mass index with increased cost of care and length of stay for emergency department patients with chest pain and dyspnea. Circ-Cardiovasc Qual Outcomes 2014; 7: 292298.CrossRefGoogle ScholarPubMed
Almashrafi, A, Alsabti, H, Mukaddirov, M, Balan, B, Aylin, P.Factors associated with prolonged length of stay following cardiac surgery in a major referral hospital in Oman: a retrospective observational study. BMJ Open 2016; 6: e010764.CrossRefGoogle Scholar
Potapov, EV, Loebe, M, Anker, S, et al.Impact of body mass index on outcome in patients after coronary artery bypass grafting with and without valve surgery. Eur Heart J 2003; 24: 19331941.CrossRefGoogle ScholarPubMed
Lui, GK, Saidi, A, Bhatt, AB, et al.Diagnosis and management of noncardiac complications in adults with congenital heart disease: a scientific statement from the American Heart Association. Circulation 2017; 136: e348e392.CrossRefGoogle ScholarPubMed
O’Byrne, ML, Kim, S, Hornik, CP, et al.Effect of obesity and underweight status on perioperative outcomes of congenital heart operations in children, adolescents, and young adults: an analysis of data from the Society of Thoracic Surgeons Database. Circulation 2017; 136: 704718.CrossRefGoogle Scholar
Buelow, MW, Earing, MG, Hill, GD, et al.The impact of obesity on postoperative outcomes in adults with congenital heart disease undergoing pulmonary valve replacement. Congenit Heart Dis 2015; 10: E197E202.CrossRefGoogle ScholarPubMed
Brida, M, Dimopoulos, K, Kempny, A, et al.Body mass index in adult congenital heart disease. Heart 2017; 103: 12501257.CrossRefGoogle ScholarPubMed
Doenst, T, Borger, MA, Weisel, RD, Yau, TM, Maganti, M, Rao, V.Relation between aortic cross-clamp time and mortality-not as straightforward as expected. Eur J Cardiothorac Surg: Official J Eur Assoc Cardiothorac Surg 2008; 33: 660665.CrossRefGoogle ScholarPubMed
Nissinen, J, Biancari, F, Wistbacka, JO, et al.Safe time limits of aortic cross-clamping and cardiopulmonary bypass in adult cardiac surgery. Perfusion 2009; 24: 297305.CrossRefGoogle ScholarPubMed
Al-Sarraf, N, Thalib, L, Hughes, A, et al.Cross-clamp time is an independent predictor of mortality and morbidity in low- and high-risk cardiac patients. Int J Surg (London, England) 2011; 9: 104109.CrossRefGoogle ScholarPubMed
Cislaghi, F, Munari, M, Corona, A, Condemi, A.Are duration of mechanical ventilation and cardiopulmonary bypass or aortic cross-clamp times correlated with hospital length of stay? EACTA 2007; 2007: 32.Google Scholar
Al-Sarraf, N, Thalib, L, Hughes, A, et al.Cross-clamp time is an independent predictor of mortality and morbidity in low- and high-risk cardiac patients. Int J Surg 2011; 9: 104109.CrossRefGoogle ScholarPubMed
Larsen, SH, Pedersen, J, Jacobsen, J, Johnsen, SP, Hansen, OK, Hjortdal, V.The RACHS-1 risk categories reflect mortality and length of stay in a Danish population of children operated for congenital heart disease. Eur J Cardiothorac Surg 2005; 28: 877881.CrossRefGoogle Scholar
Boethig, D, Jenkins, KJ, Hecker, H, Thies, W-R, Breymann, T.The RACHS-1 risk categories reflect mortality and length of hospital stay in a large German pediatric cardiac surgery population. Eur J Cardiothorac Surg 2004; 26: 1217.CrossRefGoogle Scholar