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Peripheral and respiratory muscle strength in children and adolescents with CHD: systematic review and meta-analysis

Published online by Cambridge University Press:  06 October 2022

Camila da C. Niedermeyer Open the ORCID record for Camila da C. Niedermeyer [Opens in a new window] ,
Maria Luiza Y. Shizukuishi ,
Camila W. Schaan  and
Janice L. Lukrafka
Camila da C. Niedermeyer*
Affiliation:
Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
Maria Luiza Y. Shizukuishi
Affiliation:
Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
Camila W. Schaan
Affiliation:
Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
Janice L. Lukrafka
Affiliation:
Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil
*
Author for correspondence: Camila da Cunha Niedermeyer, Rua Sarmento Leite, 245 - Centro Histórico, Porto Alegre, RS 90050-170, Brazil. E-mail: [email protected]
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Abstract

Patients with CHD are less active if compared with controls and have limited functional capacity, related to muscle weakness and fatigue. The aim of this study was to evaluate the peripheral and respiratory muscle strength of children and adolescents with CHD with systematic review and meta-analysis. The review included observational and randomised control trial studies which evaluated peripheral and respiratory muscle strength in children and adolescents with CHD under 18 years old. The peripheral muscle strength was evaluated through dynamometry and respiratory muscle strength through manovacuometry. In studies that compared patients with CHD and respective control groups, it was possible to perform a meta-analysis. A total of 5634 articles met the criteria of eligibility, 15 were included in the systematic review, and 4 were included in the meta-analysis. Twelve studies assessed peripheral muscle strength with a reduction in patients with CHD. In the meta-analysis, patients with CHD had lower muscle strength than controls (−34.07 nm; 95% CI, −67.46 to −0.68; I2 47%; p for heterogeneity = 0.05), and the meta-analysis of the handgrip muscle strength showed no significant difference between patients with CHD and controls (0.08 nm; 95% CI, −6.39 to 6.55; I2 98%; p for heterogeneity <0.00001). The meta-analysis in the present study  showed lower limb muscle strength in patients with CHD in comparison to controls. In contrast, no difference was found regarding hand grip strength. Also, the review showed lower respiratory muscle strength in patients with CHD, yet no meta-analysis was possible to perform.

Keywords

Heart defectsCongenitalMuscle strengthChildAdolescentReviewMeta-analysis
Type
Review
Information
Cardiology in the Young , Volume 32 , Issue 11 , November 2022 , pp. 1728 - 1741
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Copyright
© The Author(s), 2022. Published by Cambridge University Press

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