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A morphometric study of the human fetal heart with perimembranous ventricular septal defects

Published online by Cambridge University Press:  19 August 2008

Luis Alvarez ,
Antonia Aránega ,
Roberto Saucedo ,
Juan A. Marchal ,
Amanda R. González  and
María J. Hernández
Luis Alvarez*
Affiliation:
From the Department of Morphological Sciences, Basic Cardiovascular Research Section, School of Medicine, University of Granada, Granada
Antonia Aránega
Affiliation:
From the Department of Morphological Sciences, Basic Cardiovascular Research Section, School of Medicine, University of Granada, Granada
Roberto Saucedo
Affiliation:
and the Department of Pharmacology, School of Medicine, University of Granada, Granada
Juan A. Marchal
Affiliation:
From the Department of Morphological Sciences, Basic Cardiovascular Research Section, School of Medicine, University of Granada, Granada
Amanda R. González
Affiliation:
From the Department of Morphological Sciences, Basic Cardiovascular Research Section, School of Medicine, University of Granada, Granada
María J. Hernández
Affiliation:
From the Department of Morphological Sciences, Basic Cardiovascular Research Section, School of Medicine, University of Granada, Granada
*
Dr. Luis Alvarez, Departamento de Ciencias Morfológicas, Secciónde lnveatigación Básica Cardiovascular, Facultad de Medicina, Universidad de Granada, Avenida De Madrid 11, E-18071 Granada, Spain. Tel. 34-58-243534; Fax. 34-58-243535.
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Abstract

Morphometric methods were used to study hearts with perimembranous ventricular septal defects in 22 human fetuses and neonates weighing from one to 3.8 kg (2.221±0.852 kg). All specimens displayed concordant atrioventricular and ventriculoarterial connections, and all had perimembranous ventricular septal defects. A total of 17 interventricular parameters (nine in the right ventricle and eight in the left) were measured in each specimen. The values were compared with patterns of normality established by Rowlatt and her colleagues in hearts from 83 children ranging in age from birth to 15 years. These patterns were found to be less reliable than our own data from fetal and perinatal hearts from children ranging in age from birth to one month. Our morphological data, when appropriately interpreted, have immediate clinical and surgical applications in the treatment of fetal and perinatal cardiovascular disorders.

Keywords

Human fetal heartquantitative anatomyventriclesventricular septal defect (perimembranous type)
Type
Original Articles
Information
Cardiology in the Young , Volume 5 , Issue 1 , January 1995 , pp. 63 - 69
Copyright
Copyright © Cambridge University Press 1995

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