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Left ventricular diastolic dysfunction without left ventricular hypertrophy in obese children and adolescents: a Tissue Doppler Imaging and Cardiac Troponin I Study

Published online by Cambridge University Press:  07 August 2017

Sonia A. El Saiedi
Affiliation:
Pediatric Cardiology Unit, Pediatrics’ Department, Specialized Children Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt
Marwa F. Mira
Affiliation:
Pediatric Endocrinology Unit, Pediatrics’ Department, Specialized Children Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt
Sahar A. Sharaf
Affiliation:
Clinical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt
Maysoun M. Al Musaddar
Affiliation:
Pediatric Residency Program, Faculty of Medicine, Cairo University, Cairo, Egypt
Rania M. H. El Kaffas
Affiliation:
Pediatric Cardiology Unit, Pediatrics’ Department, Specialized Children Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt
Antoine F. AbdelMassih*
Affiliation:
Pediatric Cardiology Unit, Pediatrics’ Department, Specialized Children Hospital, Faculty of Medicine, Cairo University, Cairo, Egypt
Ihab H. Y. Barsoum
Affiliation:
October 6th University, Cairo, Egypt
*
Correspondence to: A. F. AbdelMassih, Pediatric Cardiology Unit, Pediatric Department, Pediatric Cardiology Division, Specialized Pediatric Hospital, Faculty of Medicine, Cairo University, Kasr Al Aini Street, Cairo, 12411, Egypt. Tel: +20 111 621 0610; Fax: 02-25323456; E-mail: [email protected]

Abstract

Background

Obesity increases the risk for various cardiovascular problems. Increase in body mass index is often an independent risk factor for the development of elevated blood pressure and clustering of various cardiovascular risk factors.

Objective

To determine early markers of left ventricular affection in obese patients before the appearance of left ventricular hypertrophy.

Methods

In this cross-sectional study, we evaluated 42 obese patients and 30 healthy controls. Their ages ranged from 6 to 19 years. Studied children were subjected to anthropometric, lipid profile, and serum Troponin I level measurements. Echocardiographic evaluation performed to assess the left ventricle included left ventricular dimension measurement using motion-mode echocardiography, based on which patients with left ventricular hypertrophy (10 patients) were eliminated, as well as conventional and tissue Doppler imaging.

Results

Tissue Doppler findings in the study groups showed that the ratio of transmitral early diastolic filling velocity to septal peak early diastolic myocardial velocity (E/e′) was significantly higher in cases compared with controls [6.9±1.4 versus 9.0±1.6, p (Pearson’s coefficient)=0.001, respectively]. The level of cardiac troponin I was significantly higher in cases compared with controls [0.14±0.39 ng/ml versus 0.01±0.01 ng/ml, p (Pearson’s coefficient)=0.047, respectively] and there was a significant correlation between troponin I and transmitral early diastolic filling velocity to septal peak early diastolic myocardial velocity ratio (E/e′) [R (correlation coefficient)=0.6].

Conclusion

Tissue Doppler Imaging and Troponin I evaluation proved useful tools to detect early affection of the left ventricle in obese patients even in the absence of left ventricular hypertrophy.

Type
Original Articles
Copyright
© Cambridge University Press 2017 

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