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Kawasaki disease in Jordan: demographics, presentation, and outcome

Published online by Cambridge University Press:  09 November 2011

Iyad AL-Ammouri ,
Shorouk Al-Wahsh  and
Najwa Khuri-Bulos
Iyad AL-Ammouri*
Affiliation:
Department of Pediatrics, University of Jordan, Jordan University Hospital, Amman, Jordan
Shorouk Al-Wahsh
Affiliation:
Department of Pediatrics, University of Jordan, Jordan University Hospital, Amman, Jordan
Najwa Khuri-Bulos
Affiliation:
Department of Pediatrics, University of Jordan, Jordan University Hospital, Amman, Jordan
*
Correspondence to: I. AL-Ammouri, MD, Assistant Professor of Pediatrics, Department of Pediatrics, University of Jordan, Amman 11940, Jordan. Tel: +962 6 5353666; Ext 2767; Fax: +962 6 5353444; E-mail: [email protected]
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Abstract

Kawasaki disease is the leading cause of acquired coronary artery disease in young children. There is a lack of data on Kawasaki disease and its effect on coronary arteries in Jordan and other developing countries. We report clinical and demographic data of Kawasaki disease in Jordan from a single institution, with emphasis on cardiac involvement and short to intermediate follow-up. Review of the medical records of 34 patients with Kawasaki disease from 1997 to 2010 was done for clinical and demographic variables. Echocardiographic and angiographic images were reviewed for patients at presentation and follow-up. The median age at presentation was 19 months, ranging from 2 months to 8 years, with a male to female ratio of 3.9:1. In all, 12 patients (35%) had incomplete Kawasaki disease. There was a high incidence of coronary artery involvement (41%), where 20.5% had aneurysms and 20.5% had ectasia without aneurysm. Most coronary aneurysms were present at the time of diagnosis. The only independent variable for prediction of coronary involvement was age, with an odds ratio of 0.63 per year (95% confidence interval 0.41–0.95).

Keywords

Kawasaki diseasecoronary aneurysmincomplete Kawasaki
Type
Original Article
Information
Cardiology in the Young , Volume 22 , Issue 4 , August 2012 , pp. 390 - 395
Copyright
Copyright © Cambridge University Press 2012

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References

1. Kawasaki, T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children. Arerugi 1967; 16: 178–222.Google ScholarPubMed
2. Newburger, JW, Takahashi, M, Gerber, MA, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the Committee on Rheumatic Fever, Endocarditis and Kawasaki Disease, Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2004; 110: 2747–2771.CrossRefGoogle Scholar
3. Burns, JC, Kushner, HI, Bastian, JF, et al. Kawasaki disease: a brief history. Pediatrics 2000; 106: E27, Available at http://www.pediatrics.org/cgi/content/full/106/2/e27 CrossRefGoogle ScholarPubMed
4. Holman, RC, Christensen, KY, Belay, ED, et al. Racial/ethnic differences in the incidence of Kawasaki syndrome among children in Hawaii. Hawaii Med J 2010; 69: 194–197.Google Scholar
5. Ma, XJ, Yu, CY, Huang, M, Chen, SB, Huang, MR, Huang, GY. Epidemiologic features of Kawasaki disease in Shanghai from 2003 through 2007. Chin Med J (Engl) 2010; 123: 2629–2634.Google ScholarPubMed
6. Park, YW, Han, JW, Hong, YM, et al. Epidemiological features of Kawasaki disease in Korea, 2006–2008. Pediatr Int 2011; 53: 36–39.CrossRefGoogle Scholar
7. Durongpisitkul, K, Gururaj, VJ, Park, JM, Martin, CF. The prevention of coronary artery aneurysm in Kawasaki disease: a meta-analysis on the efficacy of aspirin and immunoglobulin treatment. Pediatrics 1995; 96: 1057–1061.CrossRefGoogle ScholarPubMed
8. Suzuki, A, Kamiya, T, Kuwahara, N, et al. Coronary arterial lesions of Kawasaki disease cardiac catheterization findings of 1100 cases. Pediatr Cardiol 1986; 7: 3–9.CrossRefGoogle ScholarPubMed
9. Asadi-Pooya, AA, Borzoee, M, Amoozgar, H. The experience with 113 patients with Kawasaki disease in Fars Province, Iran. Turk J Pediatr 2006; 48: 109–114.Google ScholarPubMed
10. Bhatnagar, SK, Paul, G, Subramanian, R, Al Hosni, MS, Al Khusaiby, SM. Kawasaki disease in Oman – a clinical study. J Trop Pediatr 2003; 49: 361–366.CrossRefGoogle ScholarPubMed
11. Chemli, J, Kchaou, H, Amri, F, et al. Clinical features and course of Kawasaki disease in central Tunisia: a study about 14 cases collected over a period of three years (2000–2002). Tunis Med 2005; 83: 477–483.Google Scholar
12. Ghazal, SS, Alhowasi, M, el Samady, MM. Kawasaki disease in a paediatric hospital in Riyadh. Ann Trop Paediatr 1998; 18: 295–299.CrossRefGoogle Scholar
13. Jawad, NH, Shaltout, A, al-Momem, J, Nahar, A. Kawasaki disease: clustering in infants and pre-school children in Kuwait. Ann Trop Paediatr 1997; 17: 33–37.CrossRefGoogle ScholarPubMed
14. Majeed, HA, Olson, IA. Kawasaki disease in Kuwait. A report of two cases. Acta Paediatr Scand 1978; 67: 525–528.CrossRefGoogle ScholarPubMed
15. Ozdemir, H, Ciftci, E, Tapisiz, A, et al. Clinical and epidemiological characteristics of children with Kawasaki disease in Turkey. J Trop Pediatr 2009; 56: 260–262.CrossRefGoogle Scholar
16. Abushaban, L, Salama, A, Uthaman, B, Kumar, A, Selvan, J. Do we have a less severe form of Kawasaki disease or is it the gammaglobulin effect? Int J Cardiol 1999; 69: 71–76.CrossRefGoogle ScholarPubMed
17. Al-Harbi, KM. Kawasaki disease in Western Saudi Arabia. Saudi Med J 2010; 31: 1217–1220.Google Scholar
18. Oates-Whitehead, RM, Baumer, JH, Haines, L, et al. Intravenous immunoglobulin for the treatment of Kawasaki disease in children. Cochrane Database Syst Rev 2003: CD004000, Available at http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004000/full Google ScholarPubMed