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Increased ischaemia-modified albumin is associated with inflammation in acute rheumatic fever

Published online by Cambridge University Press:  10 May 2013

Zehra Karataş ,
Tamer Baysal ,
Fatih Şap ,
Hayrullah Alp  and
Idris Mehmetoğlu
Zehra Karataş
Affiliation:
Department of Paediatric Cardiology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
Tamer Baysal
Affiliation:
Department of Paediatric Cardiology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
Fatih Şap
Affiliation:
Department of Paediatric Cardiology, Konya Training and Research Hospital, Konya, Turkey
Hayrullah Alp
Affiliation:
Department of Paediatric Cardiology, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
Idris Mehmetoğlu
Affiliation:
Department of Biochemistry, Meram Medical Faculty, Necmettin Erbakan University, Konya, Turkey
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Abstract

Introduction: Ischaemia-modified albumin, a novel biochemical marker for tissue ischaemia, was found to be associated with oxidative stress. The purpose of this study was to assess the role of ischaemia-modified albumin in the diagnosis of acute rheumatic fever and also to evaluate the ischaemia-modified albumin levels in children with heart valve disease. Methods: The study groups, aged 5–18 years, consisted of 128 individuals – 40 with acute rheumatic fever, 35 with congenital heart valve disease, 33 with chronic rheumatic heart disease, and 20 healthy control subjects. Results: The ischaemia-modified albumin, erythrocyte sedimentation rate, and C-reactive protein levels of the acute rheumatic fever group were significantly higher than those in the chronic rheumatic heart disease, congenital heart valve disease, and control groups, separately (p < 0.001). The ischaemia-modified albumin levels in both carditis and isolated arthritis subgroups of children with acute rheumatic fever were significantly higher than in the control group (p < 0.001, p < 0.01, respectively). However, there was no statistically significant difference between the chorea subgroup and control subjects. In addition, significant correlations were observed between ischaemia-modified albumin and acute phase reactants of patients with acute rheumatic fever (p < 0.001 for both erythrocyte sedimentation rate and C-reactive protein). The ischaemia-modified albumin levels of chronic rheumatic heart disease, congenital heart valve disease, and control subjects were similar. Conclusions: The increased level of ischaemia-modified albumin in children with acute rheumatic fever seems to be associated with inflammation. However, further studies are needed to provide stronger evidence.

Keywords

Acute rheumatic feverchildrenchronic rheumatic heart diseasecongenital heart valve diseaseischaemia-modified albumin
Type
Original Articles
Information
Cardiology in the Young , Volume 24 , Issue 3 , June 2014 , pp. 430 - 436
Copyright
Copyright © Cambridge University Press 2013 

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