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Impact of platelet population behaviours in patients undergoing the Glenn procedure

Part of: Cardiac Morphology Functionally Univentricular Heart Hypoplastic Left Heart Syndrome (HLHS) Surgery

Published online by Cambridge University Press:  12 April 2021

Ergin Arslanoglu ,
Eylem Tuncer ,
Nihat Cine ,
Kenan Abdurrahman Kara Open the ORCID record for Kenan Abdurrahman Kara [Opens in a new window] ,
Babürhan Ozbek ,
Abdullah Arif Yılmaz ,
Fatih Tomrukcu ,
Omer Savluk Faruk ,
Fatma Ukil  and
Hakan Ceyran
Ergin Arslanoglu
Affiliation:
Pediatric Cardiovascular Surgery Department Kartal Kosuyolu High Speciality Educational and Research Hospital, İstanbul, Turkey
Eylem Tuncer
Affiliation:
Pediatric Cardiovascular Surgery Department Kartal Kosuyolu High Speciality Educational and Research Hospital, İstanbul, Turkey
Nihat Cine
Affiliation:
Pediatric Cardiovascular Surgery Department Kartal Kosuyolu High Speciality Educational and Research Hospital, İstanbul, Turkey
Kenan Abdurrahman Kara*
Affiliation:
Pediatric Cardiovascular Surgery Department Kartal Kosuyolu High Speciality Educational and Research Hospital, İstanbul, Turkey
Babürhan Ozbek
Affiliation:
Pediatric Cardiovascular Surgery Department Kartal Kosuyolu High Speciality Educational and Research Hospital, İstanbul, Turkey
Abdullah Arif Yılmaz
Affiliation:
Pediatric Cardiovascular Surgery Department Kartal Kosuyolu High Speciality Educational and Research Hospital, İstanbul, Turkey
Fatih Tomrukcu
Affiliation:
Pediatric Cardiovascular Surgery Department Kartal Kosuyolu High Speciality Educational and Research Hospital, İstanbul, Turkey
Omer Savluk Faruk
Affiliation:
Anaesthesia and Reanimation Department Kartal Kosuyolu High Speciality Educational and Research Hospital, İstanbul, Turkey
Fatma Ukil
Affiliation:
Anaesthesia and Reanimation Department Kartal Kosuyolu High Speciality Educational and Research Hospital, İstanbul, Turkey
Hakan Ceyran
Affiliation:
Pediatric Cardiovascular Surgery Department Kartal Kosuyolu High Speciality Educational and Research Hospital, İstanbul, Turkey
*
Author for correspondence: Kenan Abdurrahman Kara, MD, Associate Professor, Pediatric Cardiovascular Surgery Department Kartal Koşuyolu High Speciality Educational and Research Hospital, Denizer street no:2 post code:34865 Kartal İstanbul, Turkey. Tel: +905300655225. E-mail: [email protected]
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Abstract

Pulmonary pressure is one of the most important parameters in the postoperative follow-up of patients who have undergone the Glenn procedure. Platelet activation markers, which are inexpensive and easily accessible blood count parameters, have been shown to be associated with the aetiology and pathogenesis of primary pulmonary artery hypertension. We examined the relationship between platelet activation markers and pulmonary pressures in the early postoperative period of patients who underwent the Glenn procedure.

Eighty-five patients who underwent the Glenn procedure in our clinic between January 2011 and March 2020 were included in the study retrospectively. Fifty-one patients were male and 34 were female, and age varied from 4 to 416 months, with a mean of 28.64 ± 51 months.

Patients with increased pulmonary blood flow on palliation before Glenn surgery had higher mean platelet volume values. However, no correlation was found between pulmonary pressures and platelet activation markers in the early postoperative period.

There was not similar study evaluating platelet activation markers in the paediatric age group before and after postoperative Glenn surgery in the literature. Therefore, even if platelet activation markers provide information about the pulmonary bed, they may be misleading due to other reasons that trigger bleeding and inflammatory processes in the early postoperative period.

Keywords

Congenital cardiac surgeryGlenn procedurepulmonary artery hypertensionmean platelet volumeplatelet distribution widthfunctionally univentricular heart
Type
Original Article
Information
Cardiology in the Young , Volume 31 , Issue 10 , October 2021 , pp. 1675 - 1679
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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References

Badesch, DB, Champion, HC, Sanchez, MA, et al. Diagnosis and assessment of pulmonary arterial hypertension. J Am Coll Cardiol 54: 55–66.10.1016/j.jacc.2009.04.011CrossRefGoogle Scholar
Can, MM, Tanboğa, IH, Demircan, HC, et al. Enhanced hemostatic indices in patients with pulmonary arterial hypertension: an observational study. Thromb Res 2010; 126: 280–282. doi: 10.1016/j.thromres.2010.06.020. Epub 2010 Aug 1. PMID: 20673969.CrossRefGoogle ScholarPubMed
Sakao, S, Tatsumi, K. Vascular remodeling in pulmonary arterial hypertension: multiple cancer-like pathways and possible treatment modalities. Int J Cardiol 2011; 147: 4–12.CrossRefGoogle ScholarPubMed
De Luca, G, Venegoni, L, Iorio, S. Platelet distribution width and the extent of coronary artery disease: results from a large prospective study. Platelets 2010; 21: 508–514.CrossRefGoogle ScholarPubMed
Zanjani, KS. Platelets in pulmonary hypertension: a causative role or a simple association? Iran J Pediatr 2012; 22: 145–157.Google ScholarPubMed
Soydinc, S, Turkbeyler, IH, Pehlivan, Y, et al. Mean platelet volume seems to be a valuable marker in patients with systemic sclerosis. Inflammation 2014; 37: 100–106.CrossRefGoogle ScholarPubMed
Sansanayudh, N, Anothaisintawee, T, Muntham, D, McEvoy, M, Attia, J, Thakkinstian, A. Mean platelet volume and coronary artery disease: a systematic review and meta-analysis. Int J Cardiol 2014; 175: 433–440. doi: 10.1016/j.ijcard.2014.06.028. Epub 2014 Jun 28. Erratum in: Int J Cardiol. 2014 Dec 20;177(3):1145. AmmarinThakkinstian [corrected to Thakkinstian, Ammarin]. PMID: 25017904.CrossRefGoogle ScholarPubMed
Varol, E, Uysal, BA, Ozaydin, M. Platelet indices in patients with pulmonary arterial hypertension. Clin Appl Thrombosis/Hemostasis 2011; 17: E171–E174.CrossRefGoogle ScholarPubMed
Can, MM, Tanboga, IH, Demircan, HC, et al. Enhanced hemostatic indices in patients with pulmonary arterial hypertension: an observational study. Thromb Res 2010; 126: 280–282.CrossRefGoogle Scholar
Kijima, R, Sasaki, O, Shinmei, Y, et al. Changes in intraocular pressure in single ventricle patients after the Glenn or Fontan procedure. J Glaucoma 2019; 28: 1012–1014. doi: 10.1097/IJG.0000000000001375. PMID: 31567909.CrossRefGoogle ScholarPubMed
Soon, E, Holmes, AM, Treacy, CM. Elevated levels of inflammatory cytokines predict survival in idiopathic and familial pulmonary arterial hypertension. Circulation 2010; 122: 920–927.CrossRefGoogle ScholarPubMed
Debili, N, Masse, JM, Katz, A. Effects of the recombinant hematopoietic growth factors interleukin-3, interleukin-6, stem cell factor, and leukemia inhibitory factor on the megakaryocytic differentiation of CD34ş cells. Blood 1993; 82: 84–95.CrossRefGoogle Scholar
Vizioli, L, Muscari, S, Muscari, A. The relationship of mean platelet volume with the risk and prognosis of cardiovascular diseases. Int J Clin Pract 2009; 63: 1509–1515.3.CrossRefGoogle ScholarPubMed
Nakonechnicov, S, Gabbasov, Z, Chazova, I, Popov, E, Belenkov, Yu. Platelet aggregation in patients with primary pulmonary hypertension. Blood Coagulation Fibrinolysis 1996; 7: 225–227. doi: 10.1097/00001721-199603000-00029. PMID: 8735825.CrossRefGoogle ScholarPubMed
Matter, RM, Ragab, IA, Roushdy, AM, Ahmed, AG, Aly, HH, Ismail, EA. Determinants of platelet count in pediatric patients with congenital cyanotic heart disease: Role of immature platelet fraction. Congenit Heart Dis 2018; 13: 118–123. doi: 10.1111/chd.12530. Epub 2017 Sep 7. PMID: 28880458.CrossRefGoogle ScholarPubMed
Martin-Garcia, AC, Arachchillage, DR, Kempny, A, et al. Platelet count and mean platelet volume predict outcome in adults with Eisenmenger syndrome. Heart 2018; 104: 45–50. doi: 10.1136/heartjnl-2016-311144. Epub 2017 Jun 29. PMID: 28663364.CrossRefGoogle ScholarPubMed
Laskine-Holland, ML, Kahr, WH, Crawford-Lean, L, et al. The association between Cyanosis and Thromboelastometry (ROTEM) in children with congenital heart defects: a retrospective cohort study. Anesth Analg 2017; 124: 23–29. doi: 10.1213/ANE.0000000000001708. PMID: 27861436.CrossRefGoogle ScholarPubMed
Park, Y, Schoene, N, Haris, W. Mean platelet volume as an indicator of platelet activation: methodological issues. Platelets 2002; 13: 301–306.CrossRefGoogle ScholarPubMed