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Effects of cardiopulmonary bypass on the coagulation system

Published online by Cambridge University Press:  19 August 2008

L. Henry Edmunds Jr
L. Henry Edmunds Jr*
Affiliation:
From the Department of Cardiac Surgery, The Hospital of the University of Pennsylvania, Philadelphia
*
Dr. L. Henry Edmunds, Jr., Department of Gardiac Surgery, The Hospital of the University of Pennsylvania, 4 Silverstein, 3400 Spruce Street, Philadelphia, PA 19104, USA. Tel. 215-662-2091.
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Extract

Cardiopulmonary bypass makes a mess of homeostasis. Extracorporeal perfusion produces pulseless flow without physiologic controls, showers microemboli throughout the body, and brings blood diluted with additives to an enzymatic boil. Much of the morbidity associated with open heart surgery is due to contact of blood with the synthetic surfaces of the extracorporeal perfusion circuit. Bypass temporarily impairs function of every organ, alters concentrations of over 25 vasoactive substances within the plasma, and causes massive retention of fluid. In short, cardiopulmonary bypass makes patients sick.

Keywords

Heparincontact systemsplateletsfibrinolytic systemsendothelial cellsprostacyclin
Type
World Forum for Pediatric Cardiology Symposium on Cardiopulmonary Bypass (Part 1)
Information
Cardiology in the Young , Volume 3 , Issue 3 , July 1993 , pp. 251 - 256
Copyright
Copyright © Cambridge University Press 1993

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