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Do toxic metals and trace elements have a role in the pathogenesis of conotruncal heart malformations?

Published online by Cambridge University Press:  18 October 2016

Afsin A. Kundak ,
Ayhan Pektas ,
Aysegul Zenciroglu ,
Semra Ozdemir ,
Umit B. Barutcu ,
Utku A. Orun  and
Nurullah Okumus
Afsin A. Kundak
Affiliation:
Department of NeonatologyAfyon Kocatepe University Medical Faculty Hospital, Afyonkarahisar, Turkey
Ayhan Pektas*
Affiliation:
Department of Pediatric Cardiology, Afyon Kocatepe University Medical Faculty Hospital, AfyonkarahisarTurkey
Aysegul Zenciroglu
Affiliation:
Department of Neonatology, Dr. Sami Ulus Obstetrics, Gynecology and Pediatrics Research and Education Hospital, AnkaraTurkey
Semra Ozdemir
Affiliation:
Department of Biochemistry, Cerrahpasa University Medical Faculty Hospital, IstanbulTurkey
Umit B. Barutcu
Affiliation:
Department of Biochemistry, Cerrahpasa University Medical Faculty Hospital, IstanbulTurkey
Utku A. Orun
Affiliation:
Department of Pediatric Cardiology, Dr. Sami Ulus Obstetrics, Gynecology and Pediatrics Research and Education Hospital, Ankara, Turkey
Nurullah Okumus
Affiliation:
Department of Neonatology, Dr. Sami Ulus Obstetrics, Gynecology and Pediatrics Research and Education Hospital, AnkaraTurkey
*
Correspondence to: A. Pektas, MD, Selcuklu Mah. Adnan Kahveci Cad. No: 16/2 03128, Afyonkarahisar, Turkey. Tel: +90 272 246 3333, +90 532 545 1428; Fax: +90 272 246 3322; E-mail: [email protected]
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Abstract

Objective

The aim of the present study was to determine the role of toxic elements and trace elements in the pathogenesis of conotruncal heart defects by measuring their concentrations in the first meconium specimens of the affected newborns.

Methods

Concentrations of lead, cadmium, iron, zinc, and copper were measured in 1st-day meconium specimens that were collected from 60 newborns with conotruncal heart defects (Group I) and 72 healthy newborns (Group II).

Results

The newborns with conotruncal defects and the healthy newborns had statistically similar demographic and clinical characteristics. When compared with healthy newborns, mean concentrations of lead, cadmium, iron, zinc, and copper were significantly higher in newborns with conotruncal heart defects (p=0.001 for each). In total, 51 newborns with conotruncal heart defects had normal karyotype. These newborns had significantly higher concentrations of lead, cadmium, iron, zinc, and copper when compared with healthy newborns. There were significant and positive correlations between the concentrations of lead and cadmium (r=0.618, p=0.001), lead and iron (r=0.368, p=0.001), lead and zinc (r=0.245, p=0.005), lead and copper (r=0.291, p=0.001), cadmium and iron (r=0.485, p=0.001), cadmium and zinc (r=0.386, p=0.001), and cadmium and copper (r=0.329, p=0.001).

Conclusion

Toxic metals and trace elements may disturb DNA repair mechanisms by impairing DNA methylation profiles, and thus have a role in the pathogenesis of conotruncal heart defects.

Keywords

CHDtoxic metaltrace element
Type
Original Articles
Information
Cardiology in the Young , Volume 27 , Issue 2 , March 2017 , pp. 312 - 317
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Copyright
© Cambridge University Press 2016 

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References

1. Khairy, P, Ionescu-Ittu, R, Mackie, AS, et al. Changing mortality in congenital heart disease. J Am Coll Cardiol 2010; 56: 1149–1157.CrossRefGoogle ScholarPubMed
2. Richards, AA, Santos, LJ, Nichols, HA, et al. Cryptic chromosomal abnormalities identified in children with congenital heart disease. Pediatr Res 2008; 64: 358–363.CrossRefGoogle ScholarPubMed
3. Pierpont, ME, Basson, CT, Benson, DW Jr, et al. Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation 2007; 115: 3015–3038.CrossRefGoogle Scholar
4. Wessels, MW, Willems, PJ. Genetic factors in non-syndromic congenital heart malformations. Clin Genet 2010; 78: 103–123.Google Scholar
5. Marelli, AJ, Mackie, AS, Ionescu-Ittu, R, et al. Congenital heart disease in the general population. Circulation 2007; 115: 163–172.CrossRefGoogle ScholarPubMed
6. Botto, LD, Correa, A, Erickson, JD. Racial and temporal variations in the prevalence of heart defects. Pediatrics 2001; 107: e32.Google Scholar
7. Jenkins, KJ, Correa, A, Feinstein, JA, et al. Noninherited risk factors and congenital cardiovascular defects: current knowledge. Circulation 2007; 115: 2995–3014.Google Scholar
8. Malik, S, Cleves, MA, Honein, MA, et al. Maternal smoking and congenital heart defects. Pediatrics 2008; 121: e810–e816.Google Scholar
9. Oster, ME, Riehle-Colarusso, T, Alverson, CJ, et al. Associations between maternal fever and influenza and congenital heart defects. J Pediatr 2011; 158: 990–995.Google Scholar
10. Feldkamp, ML, Meyer, RE, Krikov, S, et al. Acetaminophen use in pregnancy and risk of birth defects: findings from the national birth defects prevention study. Obstet Gynecol 2010; 115: 109–115.CrossRefGoogle ScholarPubMed
11. Watkins, ML, Botto, LD. Maternal prepregnancy weight and congenital heart defects in the offspring. Epidemiology 2001; 12: 439–446.Google Scholar
12. Ostrea, EM Jr, Moroles, V, Ngoumga, E, et al. Prevalence of fetal exposure to environmental toxins as determined by meconium analysis. Neurotoxicology 2002; 23: 329–339.CrossRefGoogle ScholarPubMed
13. Taylor, A, Branch, S, Day, MP, et al. Atomic spectrometry update. Clinical and biological materials, foods and beverages. J Anal At Spectrom 2011; 26: 653–696.Google Scholar
14. Johnson, TR. Conotruncal cardiac defects: a clinical imaging perspective. Pediatr Cardiol 2010; 31: 430–437.Google Scholar
15. Gelb, BD, Chung, WK. Complex genetics and the etiology of human congenital heart disease. Cold Spring Harb Perspect Med 2014; 4: a013953.CrossRefGoogle ScholarPubMed
16. Fung, A, Manlhiot, C, Naik, S, et al. Impact of prenatal risk factors on congenital heart disease in the current era. J Am Heart Assoc 2013; 2: e000064.CrossRefGoogle ScholarPubMed
17. Blue, NR, Patel, S, Korst, LM, et al. Birth weights of fetuses with cardiac anomalies. Obstet Gynecol. 2014; 123 (Suppl 1): 39S–40S.Google Scholar
18. Yu, G, Mao, L, Chen, S. Clinical features of early newborn infants with congenital heart disease. Zhonghua Xin Xue Guan Bing Za Zhi 2014; 42: 484–486.Google Scholar
19. Kwon, C, Arnold, J, Hsiao, EC, et al. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc Natl Acad Sci USA 2007; 104: 10894–10899.Google Scholar
20. Kwon, C, Cordes, KR, Srivastava, D. Wnt/β-catenin signaling acts at multiple developmental stages to promote mammalian cardiogenesis. Cell Cycle 2008; 7: 3815–3818.Google Scholar
21. Ueno, S, Weidinger, G, Osugi, T, et al. Biphasic role for Wnt/β-catenin signaling in cardiac specification in zebrafish and embryonic stem cells. Proc Natl Acad Sci USA 2007; 104: 9685–9690.Google Scholar
22. Nafee, TM, Farrell, WE, Carroll, WD, et al. Epigenetic control of fetal gene expression. BJOG 2008; 115: 158–168.CrossRefGoogle ScholarPubMed
23. Kiefer, JC. Epigenetics in development. Dev Dyn 2007; 236: 1144–1156.Google Scholar
24. Liu, Y, Balaraman, Y, Wang, G, et al. Alcohol exposure alters DNA methylation profiles in mouse embryos at early neurulation. Epigenetics 2009; 4: 500–511.CrossRefGoogle ScholarPubMed
25. Zhou, FC, Chen, Y, Love, A. Cellular DNA methylation program during neurulation and its alteration by alcohol exposure. Birth Defects Res A Clin Mol Teratol 2011; 91: 703–715.Google Scholar
26. Salnikow, K, Zhitkovich, A. Genetic and epigenetic mechanisms in metal carcinogenesis and cocarcinogenesis: nickel, arsenic, and chromium. Chem Res Toxicol 2008; 21: 28–44.Google Scholar
27. Turker, G, Ergen, K, Karakoç, Y, et al. Concentrations of toxic metals and trace elements in the meconium of newborns from an industrial city. Biol Neonate 2006; 89: 244–250.CrossRefGoogle ScholarPubMed
28. Turker, G, Ozsoy, G, Ozdemir, S, et al. Effect of heavy metals in the meconium on preterm mortality: preliminary study. Pediatr Int 2013; 55: 30–34.Google Scholar
29. Geaghan, SM. Fetal laboratory medicine: on the frontier of maternal-fetal medicine. Clin Chem 2012; 58: 337–352.Google Scholar
30. Joya, X, Marchei, E, Salat-Batlle, J, et al. Drugs of abuse in maternal hair and paired neonatal meconium: an objective assessment of foetal exposure to gestational consumption. Drug Test Anal. 2015; 7: 257–261.Google Scholar
31. Ma, LG, Zhao, J, Ren, ZP, et al. Spatial patterns of the congenital heart disease prevalence among 0-to 14-year-old children in Sichuan Basin, P. R China, from 2004 to 2009. BMC Public Health 2014; 14: 595.CrossRefGoogle Scholar