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Do children with congenital heart defects meet the vaccination recommendations? Immunisation in children with congenital heart defects

Published online by Cambridge University Press:  27 September 2021

Julia Remmele Open the ORCID record for Julia Remmele [Opens in a new window] ,
Dominik S. Westphal ,
Carolin Unterleitner ,
Romy Becker ,
Renate Oberhoffer-Fritz ,
Alfred Hager ,
Peter Ewert  and
Annette Wacker-Gussmann
Julia Remmele*
Affiliation:
Institute of Preventive Pediatrics, TUM Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany Department of Congenital Heart Defects and Pediatric Cardiology, German Heart Center Munich, Technical University of Munich, Munich, Germany
Dominik S. Westphal
Affiliation:
Department of Internal Medicine I, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany Institute of Human Genetics, School of Medicine & Klinikum rechts der Isar, Technical University of Munich, Munich, Germany
Carolin Unterleitner
Affiliation:
Institute of Preventive Pediatrics, TUM Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany
Romy Becker
Affiliation:
Institute of Preventive Pediatrics, TUM Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany
Renate Oberhoffer-Fritz
Affiliation:
Institute of Preventive Pediatrics, TUM Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany Department of Congenital Heart Defects and Pediatric Cardiology, German Heart Center Munich, Technical University of Munich, Munich, Germany
Alfred Hager
Affiliation:
Department of Congenital Heart Defects and Pediatric Cardiology, German Heart Center Munich, Technical University of Munich, Munich, Germany
Peter Ewert
Affiliation:
Department of Congenital Heart Defects and Pediatric Cardiology, German Heart Center Munich, Technical University of Munich, Munich, Germany
Annette Wacker-Gussmann
Affiliation:
Institute of Preventive Pediatrics, TUM Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany Department of Congenital Heart Defects and Pediatric Cardiology, German Heart Center Munich, Technical University of Munich, Munich, Germany
*
Author for correspondence: J. Remmele, German Heart Center Munich, Department of Congenital Heart Defects and Pediatric Cardiology, Technical University of Munich, Lazarettstr. 36, 80636 Munich, Germany. Tel: +49 89 12 18 15 70; Fax: +49 89 1218 3013. E-mail: [email protected]
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Abstract

Introduction:

Congenital heart defects (CHDs) are the most common congenital malformations. Patients with CHD have a higher morbidity and mortality rate and are at greater risk for infectious diseases. The risk might even be higher if complex CHD occurs and if CHD is associated with additional co-morbidities. Therefore, immunisations in these children are essential.

Materials and Methods:

Individuals were recruited at the outpatient centre of the Department of Congenital Heart Defects and Pediatric Cardiology at the German Heart Center Munich in the time between February 2016 and February 2017. Included were children between 23 months and 17 years and a diagnosis of CHD. The vaccination certificate aimed to assess the immunization status.

Results:

In total, 657 children with CHD were included and analysed. Regarding primary immunisation, only 34 % (n = 221) of the children reached the complete vaccination status within the allowed catch-up time. Among these primary immunisation rates, vaccinations against Hepatitis B, Meningococci, Varicella and Pneumococci were found to have the lowest coverage with all being below 80%. The vaccination rate was partly influenced by the previously performed number of surgeries but not by the diagnosis of specific genetic diseases. At the age of school entry, the immunisation rate in children with CHD was also lower than in the comparable healthy population.

Conclusion:

The vaccination coverage rate in children with CHD is lower than in comparable healthy children, although this is a vulnerable patient group. Further education of parents and treating physicians of children with CHD regarding vaccination is still needed.

Keywords

VaccinationCHDchildren with congenital heart defectsimmunization
Type
Original Article
Information
Cardiology in the Young , Volume 32 , Issue 7 , July 2022 , pp. 1143 - 1148
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Copyright
© The Author(s), 2021. Published by Cambridge University Press

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Footnotes

*

These authors are equally contributed to the first authorship.

References

Lara, DA, Lopez, KN. Public health research in congenital heart disease. Congenit Heart Dis 2014; 9: 549–558.CrossRefGoogle ScholarPubMed
Warnes, CA, Liberthson, R, Danielson, GK, et al. Task force 1: the changing profile of congenital heart disease in adult life. J Am Coll Cardiol 2001; 37: 1170–1175.10.1016/S0735-1097(01)01272-4CrossRefGoogle ScholarPubMed
Zaidi, S, Brueckner, M. Genetics and genomics of congenital heart disease. Circ Res 2017; 120: 923–940.CrossRefGoogle ScholarPubMed
Leirgul, E, Fomina, T, Brodwall, K, et al. Birth prevalence of congenital heart defects in Norway 1994-2009--a nationwide study. Am Heart J 2014; 168: 956–964.CrossRefGoogle ScholarPubMed
Bjornard, K, Riehle-Colarusso, T, Gilboa, SM, Correa, A. Patterns in the prevalence of congenital heart defects, metropolitan Atlanta 1978 to 2005. Birth Defects Res A Clin Mol Teratol 2013; 97: 87–94.CrossRefGoogle ScholarPubMed
Naidu, P, Grigg, L, Zentner, D. Mortality in adults with congenital heart disease. Int J Cardiol 2017; 245: 125–130.CrossRefGoogle ScholarPubMed
Marelli, AJ, Mackie, AS, Ionescu-Ittu, R, Rahme, E, Pilote, L. Congenital heart disease in the general population: changing prevalence and age distribution. Circulation 2007; 115: 163–172.CrossRefGoogle ScholarPubMed
Marelli, AJ, Ionescu-Ittu, R, Mackie, AS, Guo, L, Dendukuri, N, Kaouache, M. Lifetime prevalence of congenital heart disease in the general population from 2000 to 2010. Circulation 2014; 130: 749–756.CrossRefGoogle ScholarPubMed
Woodward, CS. Keeping children with congenital heart disease healthy. J Pediatr Health Care 2011; 25: 373–378.CrossRefGoogle ScholarPubMed
Pongiglione, G, Possidoni, A, di Luzio Paparatti, U, et al. Incidence of respiratory disease during the first two years of life in children with hemodynamically significant congenital heart disease in Italy: a retrospective study. Pediatr Cardiol 2016; 37: 1581–1589.CrossRefGoogle ScholarPubMed
Kovacikova, L, Krasnanova, V, Skrak, P, et al. Immune abnormalities in patients with single ventricle circulation precede the Fontan procedure. World J Pediatr Congenit Heart Surg 2017; 8: 672–682.CrossRefGoogle ScholarPubMed
Radford, DJ, Thong, YH. The association between immunodeficiency and congenital heart disease. Pediatr Cardiol 1988; 9: 103–108.CrossRefGoogle ScholarPubMed
McDonald-McGinn, DM, Hain, HS, Emanuel, BS, Zackai, EH. 22q11.2 deletion syndrome. In: Adam, MP, Ardinger, HH, Pagon, RA, Wallace, SE, Bean, LJH, Stephens, K, et al. (eds). GeneReviews®. University of Washington, Seattle, WA, 1993.Google Scholar
Ständige Impfkommission: Empfehlungen der Ständigen Impfkommission (STIKO) am Robert Koch-Institut. Epid Bull 2019; 34: 313–364.Google Scholar
Hager, A. Impfkalender für Patienten mit angeborenem Herzfehler. Monatsschr Kinderh 2006; 154: 263–266.10.1007/s00112-006-1303-xCrossRefGoogle Scholar
Chen, M-YR-C, Yeung, T, L., F, Smith, C, Farr, SL. Children with heart conditions and their special health care needs — United States, 2016. Morbidity and Mortality Weekly Report 2018; 67: 5.Google Scholar
Deanfield, J, Thaulow, E, Warnes, C, et al. Management of grown up congenital heart disease. Euro Heart J 2003; 24: 1035–1084.CrossRefGoogle ScholarPubMed
Impfquoten bei der Schuleingangsuntersuchung in Deutschland 2015. Epid Bull 2017; 16: 137–142.Google Scholar
Vezzosi, L, Santagati, G, Angelillo, IF. Knowledge, attitudes, and behaviors of parents towards varicella and its vaccination. BMC Infect Dis 2017; 17: 172.CrossRefGoogle ScholarPubMed
van Lier, A, Tostmann, A, Harmsen, IA, de Melker, HE, Hautvast, JL, Ruijs, WL. Negative attitude and low intention to vaccinate universally against varicella among public health professionals and parents in the Netherlands: two internet surveys. BMC Infect Dis 2016; 16: 127.CrossRefGoogle ScholarPubMed
Impfempfehlungen der Ständigen Impfkommission (STIKO) am Robert Koch-Institut. Epid Bull 2001; 28: 203–218.Google Scholar
Begründung der STIKO-Empfehlungen zur Impfung gegen Pneumokokken und Meningokokken vom Juli 2006. Epid Bull 2006; 31: 255–270.Google Scholar
Harmsen, IA, Ruiter, RA, Paulussen, TG, Mollema, L, Kok, G, de Melker, HE. Factors that influence vaccination decision-making by parents who visit an anthroposophical child welfare center: a focus group study. Adv Prev Med 2012; 2012: 175694.CrossRefGoogle Scholar
Hak, E, Schonbeck, Y, De Melker, H, Van Essen, GA, Sanders, EA. Negative attitude of highly educated parents and health care workers towards future vaccinations in the Dutch childhood vaccination program. Vaccine 2005; 23: 3103–3107.CrossRefGoogle ScholarPubMed
Lantin-Hermoso, MR, Berger, S, Bhatt, AB, et al. The care of children with congenital heart disease in their primary medical home. Pediatrics 2017; 140: e20172607.CrossRefGoogle ScholarPubMed
Helm, PC, Ortmann, K, Steinmann, L, Bauer, U, A., H. Unzureichender Impfschutz bei chronisch kranken Patienten mit angeborenem Herzfehler. Pädiatrische Praxis 2016; 84: 575–580.Google Scholar
Ram, G, Chinen, J. Infections and immunodeficiency in Down syndrome. Clin Exp Immunol 2011; 164: 9–16.10.1111/j.1365-2249.2011.04335.xCrossRefGoogle ScholarPubMed
Triedman, JK, Newburger, JW. Trends in congenital heart disease: the next decade. Circulation 2016; 133: 2716–2733.CrossRefGoogle ScholarPubMed