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Comparison of epicardial fat thickness in macrosomic and non-macrosomic infants of mothers with diabetes

Published online by Cambridge University Press:  10 April 2025

Celal Varan  and
Ali Orgun Open the ORCID record for Ali Orgun [Opens in a new window]
Celal Varan
Affiliation:
Department of Pediatric Cardiology, Adana City Training and Research Hospital, Adana, Turkey
Ali Orgun*
Affiliation:
Department of Pediatric Cardiology, Adana City Training and Research Hospital, Adana, Turkey
*
Corresponding author: Ali Orgun; Email: aliorgun2014@gmail.com
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Abstract

Background:

Epicardial fat thickness also increases in insulin resistance and diabetes mellitus patients. In our study, we aimed to compare the epicardial fat thickness and interventricular septum diameter in infants of mothers with diabetes with infants of mothers without diabetes. Also, to determine the effect of birth weight on the epicardial fat thickness and the interventricular septum diameter in infants of mothers with diabetes.

Materials and methods:

Between November 2022 and June 2023, infants of mothers with diabetes and healthy infants were compared. According to birth weight, infants of mothers with diabetes were divided into two groups, macrosomic infants (≥ 4000 g) and non-macrosomic infants (2500–4000 g).

Results:

A total of 78 infants of mothers with diabetes and 56 infants of mothers without diabetes were evaluated. Epicardial fat thickness and interventricular septum diameter were found to be statistically significantly higher in infants of mothers with diabetes than in healthy infants. Epicardial fat thickness and interventricular septum diameter measurements were found to be statistically significantly higher in the macrosomic of infants than in the non-macrosomic of infants of mothers with diabetes. Asymmetric septal hypertrophy was found to be more common in macrosomic infants of diabetic mothers than in non-macrosomic infants, although not statistically significant. We also found a positive correlation between epicardial fat thickness and asymmetric septal hypertrophy.

Conclusions:

Epicardial fat thickness is observed to increase along with neonatal macrosomia and heart mass in gestational diabetes mellitus. The lack of a significant increase in epicardial fat thickness and interventricular septum diameter in non-macrosomic infants of mothers with diabetes may be indicative of good glycaemic control in non-macrosomic infants of mothers with diabetes. Therefore, good glycaemic control during pregnancy and long-term follow-up of infants of mothers with diabetes after birth is important.

Keywords

Epicardial fat thicknessgestational diabetes mellitusinfantmacrosomia
Type
Original Article
Information
Cardiology in the Young , First View , pp. 1 - 5
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Copyright
© The Author(s), 2025. Published by Cambridge University Press

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References

Monti, M, Marchetti, R, Vincentelli, GM. Epicardial fat, gender, and cardiovascular risk. Ital J Med 2021; 15 ( 2 ): 93–98. doi: 10.4081/itjm.2021.1349.CrossRefGoogle Scholar
Al-Biltagi, M, El Razaky, O, El Amrousy, D. Cardiac changes in infants of diabetic mothers. World J Diabetes 2021; 12 ( 8 ): 1233–1247. doi: 10.4239/wjd.v12.i8.1233.CrossRefGoogle ScholarPubMed
Weber, HS, Copel, JA, Reece, EA, Green, J, Kleinman, CS. Cardiac growth in fetuses of diabetic mothers with good metabolic control. J Pediatr 1991; 118 ( 1 ): 103–107.CrossRefGoogle ScholarPubMed
Litwin, L, Sundholm, JKM, Rono, K, Koivusalo, SB, Eriksson, JG, Sarkola, T. Transgenerational effects of maternal obesity and gestational diabetes on offspring body composition and left ventricle mass: the finnish gestational diabetes prevention study (RADIEL) 6-year follow-up. Diabet Med 2020; 37 ( 1 ): 147–156. doi: 10.1111/dme.14089.CrossRefGoogle ScholarPubMed
Yavuz, A, Akkurt, M, Yalcin, S, Karakoc, G, Varol, E, Sezik, M. Second trimester fetal and maternal epicardial fat thickness in gestational diabetic pregnancies. Horm Metab Res 2016; 48 ( 09 ): 595–600.Google ScholarPubMed
Iacobellis, G, Malavazos, AE, Corsi, MM. Epicardial fat: from the biomolecular aspects to the clinical practice. Int J Biochem Cell Biol 2011; 43 ( 12 ): 1651–1654. doi: 10.1016/j.biocel.2011.09.006.CrossRefGoogle Scholar
ElSayed, NA, Aleppo, G, Aroda, VR, et al. 2. Classification and diagnosis of diabetes: standards of care in diabetes—2023. Diabetes Care 2023; 46: S19–S40.CrossRefGoogle ScholarPubMed
Ozdemir, O, Hizli, S, Abaci, A, Agladioglu, K, Aksoy, S. Echocardiographic measurement of epicardial adipose tissue in obese children. Pediatr Cardiol 2010; 31: 853–860.CrossRefGoogle ScholarPubMed
Avci, ME, Tosun, Ö. Evaluation of subclinical atherosclerosis and cardiac functions in children of mothers with gestational diabetes and maternal obesity. Cardiol Young 2023; 33 ( 7 ): 1157–1164.CrossRefGoogle Scholar
Vela-Huerta, MM, Amador-Licona, N, Dominguez-Damian, R, et al. Epicardial fat thickness in infants of diabetic mothers. J Neonatal Perinatal Med 2022; 15 ( 1 ): 75–80. doi: 10.3233/NPM-210787.CrossRefGoogle ScholarPubMed
Gaborit, B, Sengenes, C, Ancel, P, Jacquier, A, Dutour-Meyer, A. Role of epicardial adipose tissue in health and disease: a matter of fat? Compr Physiol 2017; 7 ( 3 ): 317.CrossRefGoogle ScholarPubMed
A.Lawlor, D, Fraser, A, Lindsay, R, et al. Association of existing diabetes, gestational diabetes and glycosuria in pregnancy with macrosomia and offspring body mass index, waist and fat mass in later childhood: findings from a prospective pregnancy cohort. Diabetologia 2010; 53: 89–97.CrossRefGoogle Scholar
Kozák-Bárány, A, Jokinen, E, Kero, P, Tuominen, J, Rönnemaa, T, Välimäki, I. Impaired left ventricular diastolic function in newborn infants of mothers with pregestational or gestational diabetes with good glycemic control. Early Hum Dev 2004; 77 ( 1-2 ): 13–22.CrossRefGoogle ScholarPubMed
Rijpert, M, Breur, JM, Evers, IM, et al. Cardiac function in 7–8-year-old offspring of women with type 1 diabetes. Exp Diabetes Res 2011; 2011: 1–7.CrossRefGoogle ScholarPubMed