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Cardiac functions and aortic elasticity in children with inflammatory bowel disease: effect of age at disease onset

Published online by Cambridge University Press:  22 January 2020

Elif Erolu Open the ORCID record for Elif Erolu [Opens in a new window]  and
Esra Polat Open the ORCID record for Esra Polat [Opens in a new window]
Elif Erolu*
Affiliation:
Departmant of Pediatrics, Division of Pediatric Cardiology, Istanbul Health Sciences University, Umraniye Education and Research Hospital, Istanbul, Turkey
Esra Polat
Affiliation:
Departmant of Pediatrics, Division of Pediatric Gastroenterology, Istanbul Health Sciences University, Umraniye Education and Research Hospital, Istanbul, Turkey
*
Author for correspondence: E. Erolu, Elmalıkent Mahallesi, Adem Yavuz Cd., 34764 Istanbul, Turkey. Tel: +905058169456; Fax: (+90216) 632 71 24/(+90216) 632 71 21; E-mail: [email protected]
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Abstract

Aim:

Childhood onset inflammatory bowel disease is more aggressive and has rapidly progressive clinical course than adult inflammatory bowel disease. Early-onset inflammatory bowel disease has more severe clinical progression as a subspecialised group of monogenic inflammatory bowel disease. We studied cardiac functions and aortic elasticity in children with early- and late-onset inflammatory bowel disease in remission period.

Methods:

Thirty-three paediatric patients were divided into subgroups according to age of disease onset (<10 and >10 years of age). Twenty-five healthy children were admitted as control group. M-Mode echocardiography and pulsed wave Doppler echocardiography were performed. Strain, distensibility, stiffness index of ascending, and abdominal aorta were evaluated.

Results:

Interventricular septum (mm) and left ventricular end-systolic diameter were higher (6.9 ± 1.2, 26.2 ± 4.6) in early-onset inflammatory bowel disease patients than control patients (6.1 ± 1.27, 22.7 ± 4.12) (p = 0.050, p = 0.050). Mitral E/E′ ratio and myocardial performance index were increased in inflammatory bowel disease and early-onset inflammatory bowel disease groups than control group (p = 0.046, p = 0.04; p = 0.023, p = 0.033). Diastolic functions were found to be impaired in inflammatory bowel disease and early-onset inflammatory bowel disease groups according to control group, while there was no difference between late-onset inflammatory bowel disease and control groups in terms of diastolic functions. Mitral E/A ratio was lower in inflammatory bowel disease patients and early-onset inflammatory bowel disease patients (1.46 ± 0.32, 1.4 ± 0.21) than control patients (1.70 ± 0.27) (p = 0.013, p = 0.004). Aortic elasticity did not differ between groups.

Conclusion:

Chronic low-grade inflammation has effects on left ventricular diameters and diastolic function in remission period. Aortic elasticity is not affected in our study groups.

Keywords

Inflammatory bowel diseasemyocardial functionsaortic elasticityearly-onset inflammatory bowel diseaselate-onset inflammatory bowel disease
Type
Original Article
Information
Cardiology in the Young , Volume 30 , Issue 3 , March 2020 , pp. 313 - 317
Copyright
© Cambridge University Press 2020

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