Hostname: page-component-78c5997874-fbnjt Total loading time: 0 Render date: 2024-11-16T07:26:26.210Z Has data issue: false hasContentIssue false
  • English
  • Français

Association of MnSOD gene polymorphism with susceptibility to Kawasaki disease in Chinese children

Published online by Cambridge University Press:  30 October 2020

Jiping Wu Open the ORCID record for Jiping Wu [Opens in a new window] ,
Meng Yu ,
Lihua Huang ,
Yujie Qian ,
Min Kong ,
Zhijuan Kang  and
Zuocheng Yang
Jiping Wu
Affiliation:
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Meng Yu
Affiliation:
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Lihua Huang
Affiliation:
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Yujie Qian
Affiliation:
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Min Kong
Affiliation:
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Zhijuan Kang
Affiliation:
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
Zuocheng Yang*
Affiliation:
Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, China
*
Author for correspondence: Z. Yang, MD, Department of Pediatrics, The Third Xiangya Hospital, Central South University, 138 Tongzipo Road, Changsha, Hunan 410013, China. E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background:

Kawasaki disease is a type of acute febrile rash disease that is common in children and is characterised by primary lesions of systemic middle and small vasculitis, which can lead to coronary artery lesions. Manganese superoxide dismutase (MnSOD), one of the most important antioxidases in the human body, plays a key role in maintaining the balance of free radicals in the human body. Two single-nucleotide polymorphisms (SNPS) (rs4880 and rs5746136) in the MnSOD gene were related to oxidative stress disease. The purpose of this study is to explore the possible relationship between MnSOD gene polymorphisms and Kawasaki disease susceptibility.

Methods:

This study included 100 Kawasaki disease children and 102 healthy children. Two single-nucleotide polymorphisms (rs4880 and rs5746136) were detected by polymerase chain reaction sequence-based typing.

Results:

There was a significant difference in both the genotype frequency (χ2 = 10.805, p = 0.005) and the allele frequency (χ2 = 7.948, p = 0.005) of rs5746136 between the Kawasaki disease group and the control group. Children with the A allele had a 0.558 times lower risk of Kawasaki disease than those without the A allele (χ2 = 7.948, p = 0.005, odds ratio = 0.558, 95% confidence interval = 0.371–0.838). There was no significant difference in the genotype and gene frequencies of rs5746136 between the Kawasaki disease-coronary artery lesion and Kawasaki disease-without coronary artery lesion groups (p > 0.05), and there was no significant difference in the rs4880 genotype and allele frequencies between the Kawasaki disease and healthy control groups or between the Kawasaki disease-coronary artery lesion and Kawasaki disease-without coronary artery lesions groups (p > 0.05).

Conclusion:

This study provides evidence supporting an association between MnSOD gene polymorphisms and susceptibility to Kawasaki disease. The genotype AA and the allele A of the MnSOD gene locus rs5746136 were risk factors for Kawasaki disease.

Keywords

Kawasaki diseaseMnSOD genegene polymorphismchildren
Type
Original Article
Information
Cardiology in the Young , Volume 31 , Issue 2 , February 2021 , pp. 179 - 185
Check for updates
Copyright
© The Author(s), 2020. Published by Cambridge University Press

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Kawasaki, T. Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children [in Japanese]. Arerugi 1967; 16: 178–222.Google Scholar
Newburger, JW, Takahashi, M, Burns, JC. Kawasaki disease. J Am Coll Cardiol 2016; 67: 1738–1749.CrossRefGoogle ScholarPubMed
Agarwal, S, Agrawal, DK. Kawasaki disease: etiopathogenesis and novel treatment strategies. Expert Rev Clin Immunol 2017; 3, 247–258.CrossRefGoogle Scholar
Greco, A, De Virgilio, A, Rizzo, MI, et al. Kawasaki disease: an evolving paradigm. Autoimmun Rev 2015; 14: 703–709.CrossRefGoogle Scholar
Uehara, R, Yashiro, M, Nakamura, Y, et al. Parents with a history of Kawasaki disease whose child also had the same disease. Pediatr Int 2011; 53: 511–514.CrossRefGoogle ScholarPubMed
Onouchi, Y, Gunji, T, Burns, JC, et al. ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nat Genet 2008; 40: 35–42.CrossRefGoogle ScholarPubMed
Onouchi, Y, Suzuki, Y, Suzuki, H, et al. ITPKC and CASP3 polymorphisms and risks for IVIG unresponsiveness and coronary artery lesion formation in Kawasaki disease. Pharmacogenomics J 2013; 13: 52–59.CrossRefGoogle ScholarPubMed
Onouchi, Y, Fukazawa, R, Yamamura, K, et al. Variations in ORAI1 gene associated with Kawasaki disease. PLoS One 2016; 11: e145486.CrossRefGoogle ScholarPubMed
Bae, Y, Shin, D, Nam, J, et al. Variants in the gene EBF2 are associated with Kawasaki disease in a Korean population. Yonsei Med J 2018; 59: 519–523.CrossRefGoogle Scholar
Kim, KY, Bae, YS, Ji, W, et al. ITPKC and SLC11A1 gene polymorphisms and gene–gene interactions in Korean patients with Kawasaki disease. Yonsei Med J 2018; 59: 119–127.CrossRefGoogle ScholarPubMed
Li, Z, Han, D, Jiang, J, et al. Association of PECAM-1 gene polymorphisms with Kawasaki disease in Chinese children. Dis Markers 2017; 2017: 2960502.CrossRefGoogle ScholarPubMed
Lu, Y, Liu, R, Zha, L, et al. Association of thrombomodulin gene C1418T polymorphism with susceptibility to Kawasaki disease in Chinese children. Dis Markers 2018; 2018: 1064380.CrossRefGoogle ScholarPubMed
Yahata, T, Hamaoka, K. Oxidative stress and Kawasaki disease: how is oxidative stress involved from the acute stage to the chronic stage? Rheumatology (Oxford) 2017; 56: 6–13.CrossRefGoogle Scholar
Sheshadri, P, Kumar, A. Managing odds in stem cells: insights into the role of mitochondrial antioxidant enzyme MnSOD. Free Radic Res 2016; 50: 570–584.CrossRefGoogle ScholarPubMed
Ayusawa, M, Sonobe, T, Uemura, S, et al. Revision of diagnostic guidelines for Kawasaki disease (the 5th revised edition). Pediatr Int 2005; 47: 232–234.CrossRefGoogle Scholar
JCS Joint Working Group. Guidelines for diagnosis and management of cardiovascular sequelae in Kawasaki disease (JCS 2013). Digest version. Circ J 2014; 78: 2521–2562.CrossRefGoogle Scholar
Shulman, ST, Rowley, AH. Kawasaki disease: insights into pathogenesis and approaches to treatment. Nat Rev Rheumatol 2015; 11: 475–482.CrossRefGoogle ScholarPubMed
Takahashi, K, Oharaseki, T, Naoe, S, et al. Neutrophilic involvement in the damage to coronary arteries in acute stage of Kawasaki disease. Pediatr Int 2005; 47: 305–310.CrossRefGoogle ScholarPubMed
Griendling, KK, Sorescu, D, Ushio-Fukai, M. NAD(P)H oxidase: role in cardiovascular biology and disease. Circ Res 2000; 86: 494–501.CrossRefGoogle ScholarPubMed
Lin, IC, Sheen, JM, Tain, YL, et al. Vascular endothelial growth factor-a in lactobacillus casei cell wall extract-induced coronary arteritis of a murine model. Circ J 2014; 78: 752–762.CrossRefGoogle ScholarPubMed
Ishikawa, T, Seki, K. The association between oxidative stress and endothelial dysfunction in early childhood patients with Kawasaki disease. BMC Cardiovasc Disord 2018; 18: 30.CrossRefGoogle ScholarPubMed
Teranishi, M, Uchida, Y, Nishio, N, et al. Polymorphisms in genes involved in oxidative stress response in patients with sudden sensorineural hearing loss and Ménière’s disease in a Japanese population. DNA Cell Biol 2012; 31: 1555–1562.CrossRefGoogle Scholar
Park, HY, Kim, JH, Lim, YH, et al. Influence of genetic polymorphisms on the association between phthalate exposure and pulmonary function in the elderly. Environ Res 2013; 122: 18–24.CrossRefGoogle ScholarPubMed
Mohammedi, K, Bellili-Muñoz, N, Driss, F, et al. Manganese superoxide dismutase (SOD2) polymorphisms, plasma advanced oxidation protein products (AOPP) concentration and risk of kidney complications in subjects with type 1 diabetes. PLoS One 2014; 9: e96916.CrossRefGoogle ScholarPubMed
Boroumand, F, Mahmoudinasab, H, Saadat, M. Association of the SOD2 (rs2758339 and rs5746136) polymorphisms with the risk of heroin dependency and the SOD2 expression levels. Gene 2018; 649: 27–31.CrossRefGoogle ScholarPubMed
Pourvali, K, Abbasi, M, Mottaghi, A. Role of superoxide dismutase 2 gene Ala16Val polymorphism and total antioxidant capacity in diabetes and its complications. Avicenna J Med Biotechnol 2016; 8: 48–56.Google ScholarPubMed
Bresciani, G, Cruz, IB, de Paz, JA, et al. The MnSOD Ala16Val SNP: relevance to human diseases and interaction with environmental factors. Free Radic Res 2013; 47: 781–792.CrossRefGoogle ScholarPubMed
Yahya, MJ, Ismail, PB, Nordin, NB, et al. CNDP1, NOS3, and MnSOD polymorphisms as risk factors for diabetic nephropathy among type 2 diabetic patients in Malaysia. J Nutr Metab 2019; 2019: 8736215.CrossRefGoogle ScholarPubMed
Griendling, KK, FitzGerald, GA. Oxidative stress and cardiovascular injury: part II: animal and human studies. Circulation 2003; 108: 2034–2040.CrossRefGoogle ScholarPubMed
Souiden, Y, Mallouli, H, Meskhi, S, et al. MnSOD and GPx1 polymorphism relationship with coronary heart disease risk and severity. Biol Res 2016; 49: 22.CrossRefGoogle ScholarPubMed
Li, JY, Tao, F, Wu, XX, et al. Polymorphic variations in manganese superoxide dismutase (MnSOD) and endothelial nitric oxide synthase (eNOS) genes contribute to the development of type 2 diabetes mellitus in the Chinese Han population. Genet Mol Res 2015; 14: 12993–13002.CrossRefGoogle ScholarPubMed
Tetik, VA, Harman, E, Bozok, CV, et al. Polymorphisms of lipid metabolism enzyme-coding genes in patients with diabetic dyslipidemia. Anatol J Cardiol 2017; 17 313–321.Google Scholar
Isikli, A, Kubat-Uzum, A, Satman, I, et al. A SOD2 polymorphism is associated with abnormal quantitative sensory testing in type 2 diabetic patients. Noro Psikiyatr Ars 2018; 55: 276–279.Google ScholarPubMed
Wang, IJ, Karmaus, WJ. Oxidative stress-related genetic variants may modify associations of phthalate exposures with asthma. Int J Environ Res Public Health 2017; 14: 1–14.Google ScholarPubMed
Zhou, Y, Shuai, P, Li, X, et al. Association of SOD2 polymorphisms with primary open angle glaucoma in a Chinese population. Ophthalmic Genet 2015; 36: 43–49.CrossRefGoogle ScholarPubMed
Ding, G, Liu, F, Shen, B, et al. The association between polymorphisms in prooxidant or antioxidant enzymes (myeloperoxidase, SOD2, and CAT) and genes and prostate cancer risk in the Chinese population of Han nationality. Clin Genitourin Cancer 2012; 10: 251–255.CrossRefGoogle ScholarPubMed
Valdivia, A, Perez-Alvarez, S, Aroca-Aguilar, JD, et al. Superoxide dismutases: a physiopharmacological update. J Physiol Biochem 2009; 65: 195–208.CrossRefGoogle ScholarPubMed
Janus, A, Szahidewicz-Krupska, E, Mazur, G, et al. Insulin resistance and endothelial dysfunction constitute a common therapeutic target in cardiometabolic disorders. Mediators Inflamm 2016; 2016: 3634948.CrossRefGoogle ScholarPubMed
Buttery, LD, Springall, DR, Chester, AH, et al. Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxynitrite. Lab Invest 1996; 75: 77–85.Google ScholarPubMed