Hostname: page-component-cd9895bd7-8ctnn Total loading time: 0 Render date: 2024-12-29T11:10:39.708Z Has data issue: false hasContentIssue false
  • English
  • Français

Association between polymorphisms in IL27 and risk for CHD in a Chinese population

Published online by Cambridge University Press:  09 February 2015

Danyan Zhang ,
Mingfu Ma ,
Yuyou Yang ,
Ling Wan ,
Zhixi Yang ,
Jing Lv ,
Xinsheng Li ,
Hao Yang ,
Pei Huang  and
Lianbing Li
Danyan Zhang
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Mingfu Ma
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Yuyou Yang
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Ling Wan
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Zhixi Yang
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Jing Lv
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Xinsheng Li
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Hao Yang
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
Pei Huang
Affiliation:
The Third Military Medical University, Chongqing, P.R. China
Lianbing Li*
Affiliation:
Key Laboratory of Birth Defects and Reproductive Health of National Health and Family Planning Commission, Chongqing, P.R. China Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing, P.R. China Chongqing Zheng-ding Judicial Identification Institute, Chongqing, P.R. China
*
Correspondence to: L. Li, Chongqing Population and Family Planning Science and Technology Research Institute, Chongqing 400020, P.R. China. Tel: + 86 236 786 7492; Fax: +86 238 671 5000; E-mail: [email protected]
Get access Rights & Permissions [Opens in a new window]

Abstract

Background

IL-27, a member of the IL-12 family, has been involved in maternal tolerance to the foetus and successful pregnancy. Growing evidences indicate that IL-27 plays a crucial role in pregnancy.

Aim

We carried out the present study in order to investigate whether polymorphisms in the IL27 are associated with the risk for CHDs, including atrial septal defect and ventricular septal defect.

Patients and methods

We conducted this case–control study among 247 atrial septal defect patients, 150 ventricular septal defect patients, and 368 healthy controls in a Chinese population using polymerase chain reaction-restriction fragment length polymorphism assay.

Results

Significantly increased risk for atrial septal defect (p=0.001, OR=1.490, 95% CI=1.178–1.887) and ventricular septal defect (p=0.004, OR=1.502, 95% CI=1.139–1.976) was observed to be associated with the allele G of rs153109. In a dominant model, we have also observed that increased susceptibilities for atrial septal defect (p<0.01, OR=1.89, 95% CI=1.35–2.63) and ventricular septal defect (p<0.01, OR=2.50, 95% CI=1.67–3.85) were statistically associated with rs153109; however, no association was found between CHD risk and rs17855750 in the IL27 gene.

Conclusion

The 153109 of the IL27 gene may be associated with the susceptibility to CHD, including atrial septal defect and ventricular septal defect.

Keywords

CHDIL27polymorphismsgenetic susceptibilitycytokine
Type
Original Articles
Information
Cardiology in the Young , Volume 26 , Issue 2 , February 2016 , pp. 237 - 243
Check for updates
Copyright
© Cambridge University Press 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

1. Mitchell, SC, Korones, SB, Berendes, HW. Congenital heart disease in 56,109 births. Incidence and natural history. Circulation 1971; 43: 323–332.Google Scholar
2. Pierpont, ME, Basson, CT, Benson, DW Jr, et al. Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation 2007; 115: 3015–3038.Google Scholar
3. Srivastava, D. Making or breaking the heart: from lineage determination to morphogenesis. Cell 2006; 126: 1037–1048.Google Scholar
4. Chinawa, JM, Obu, HA, Eke, CB, Eze, JC. Pattern and clinical profile of children with complex cardiac anomaly at University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu State, Nigeria. Niger J Clin Pract 2013; 16: 462–467.CrossRefGoogle ScholarPubMed
5. Hoffman, JI, Kaplan, S. The incidence of congenital heart disease. J Am Coll Cardiol 2002; 39: 1890–1900.Google Scholar
6. Geva, T, Martins, JD, Wald, RM. Atrial septal defects. Lancet 2014; 383: 1921–1932.Google Scholar
7. Maitra, M, Schluterman, MK, Nichols, HA, et al. Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development. Dev Biol 2009; 326: 368–377.Google Scholar
8. Hoffman, JI. Incidence of congenital heart disease: I. Postnatal incidence. Pediatr Cardiol 1995; 16: 103–113.Google Scholar
9. Garg, V, Kathiriya, IS, Barnes, R, et al. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5. Nature 2003; 424: 443–447.Google Scholar
10. Gong, W, Gottlieb, S, Collins, J, et al. Mutation analysis of TBX1 in non-deleted patients with features of DGS/VCFS or isolated cardiovascular defects. J Med Genet 2001; 38: E45.CrossRefGoogle ScholarPubMed
11. Schott, JJ, Benson, DW, Basson, CT, et al. Congenital heart disease caused by mutations in the transcription factor NKX2-5. Science 1998; 281: 108–111.Google Scholar
12. Ostojic, S, Dubanchet, S, Chaouat, G, Abdelkarim, M, Truyens, C, Capron, F. Demonstration of the presence of IL-16, IL-17 and IL-18 at the murine fetomaternal interface during murine pregnancy. Am J Reprod Immunol 2003; 49: 101–112.CrossRefGoogle ScholarPubMed
13. Rodriguez-Burgos, A, Juarez, L. Developmental delay and other anomalies in the offspring from hens immunized against soluble and foreign chick embryo antigens. Am J Reprod Immunol 2008; 60: 141–150.Google Scholar
14. Murugaiyan, G, Saha, B. IL-27 in tumor immunity and immunotherapy. Trends Mol Med 2013; 19: 108–116.Google Scholar
15. Pflanz, S, Timans, JC, Cheung, J, et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 2002; 16: 779–790.Google Scholar
16. Devergne, O, Hummel, M, Koeppen, H, et al. A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J Virol 1996; 70: 1143–1153.CrossRefGoogle ScholarPubMed
17. Pflanz, S, Hibbert, L, Mattson, J, et al. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol 2004; 172: 2225–2231.CrossRefGoogle ScholarPubMed
18. Zhang, Z, Zhou, B, Wu, Y, et al. Prognostic value of IL-27 polymorphisms and the susceptibility to epithelial ovarian cancer in a Chinese population. Immunogenetics 2014; 66: 85–92.Google Scholar
19. Laird, SM, Tuckerman, EM, Li, TC. Cytokine expression in the endometrium of women with implantation failure and recurrent miscarriage. Reprod Biomed Online 2006; 13: 13–23.Google Scholar
20. Coulomb-L’Hermine, A, Larousserie, F, Pflanz, S, Bardel, E, Kastelein, RA, Devergne, O. Expression of interleukin-27 by human trophoblast cells. Placenta 2007; 28: 1133–1140.Google Scholar
21. Shi, S, Zhou, B, Zhang, K, Zhang, L. Association between two genetic variants of CD226 gene and Cervical Squamous Cell Carcinoma: a case-control study. Gene 2013; 519: 159–163.Google Scholar
22. Tao, YP, Wang, WL, Li, SY, et al. Associations between polymorphisms in IL-12A, IL-12B, IL-12Rbeta1, IL-27 gene and serum levels of IL-12p40, IL-27p28 with esophageal cancer. J Cancer Res Clin Oncol 2012; 138: 1891–1900.Google Scholar
23. Shen, Y, Yuan, XD, Hu, D, et al. Association between Interleukin-27 gene polymorphisms and susceptibility to allergic rhinitis. Hum Immunol 2014; 75: 991–995.Google Scholar
24. Huang, N, Liu, L, Wang, XZ, Liu, D, Yin, SY, Yang, XD. Association of interleukin (IL)-12 and IL-27 gene polymorphisms with chronic obstructive pulmonary disease in a Chinese population. DNA Cell Biol 2008; 27: 527–531.Google Scholar
25. Sole, X, Guino, E, Valls, J, Iniesta, R, Moreno, V. SNPStats: a web tool for the analysis of association studies. Bioinformatics 2006; 22: 1928–1929.Google Scholar
26. Mas, AE, Petitbarat, M, Dubanchet, S, Fay, S, Ledee, N, Chaouat, G. Immune regulation at the interface during early steps of murine implantation: involvement of two new cytokines of the IL-12 family (IL-23 and IL-27) and of TWEAK. Am J Reprod Immunol 2008; 59: 323–338.Google Scholar
27. Cleves, MA, Malik, S, Yang, S, Carter, TC, Hobbs, CA. Maternal urinary tract infections and selected cardiovascular malformations. Birth Defects Res A Clin Mol Teratol 2008; 82: 464–473.Google Scholar
28. Blossom, SJ, Rau, JL, Best, TH, Bornemeier, RA, Hobbs, CA. Increased maternal cytokine production and congenital heart defects. J Reprod Immunol 2013; 97: 204–210.Google Scholar
29. Mann, DL, Young, JB. Basic mechanisms in congestive heart failure. Recognizing the role of proinflammatory cytokines. Chest 1994; 105: 897–904.Google Scholar
30. Kriszbacher, I, Koppan, M, Bodis, J. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005; 353: 429–430.Google Scholar
31. Werdan, K. The activated immune system in congestive heart failure – from dropsy to the cytokine paradigm. J Intern Med 1998; 243: 87–92.Google Scholar
32. Buchhorn, R, Wessel, A, Hulpke-Wette, M, Bursch, J, Werdan, K, Loppnow, H. Endogenous nitric oxide and soluble tumor necrosis factor receptor levels are enhanced in infants with congenital heart disease. Crit Care Med 2001; 29: 2208–2210.Google Scholar
33. Devergne, O, Birkenbach, M, Kieff, E. Epstein-Barr virus-induced gene 3 and the p35 subunit of interleukin 12 form a novel heterodimeric hematopoietin. Proc Natl Acad Sci U S A 1997; 94: 12041–12046.CrossRefGoogle Scholar
34. Devergne, O, Coulomb-L’Hermine, A, Capel, F, Moussa, M, Capron, F. Expression of Epstein-Barr virus-induced gene 3, an interleukin-12 p40-related molecule, throughout human pregnancy: involvement of syncytiotrophoblasts and extravillous trophoblasts. Am J Pathol 2001; 159: 1763–1776.Google Scholar
35. Hunter, CA. New IL-12-family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Immunol 2005; 5: 521–531.Google Scholar
36. Gee, K, Guzzo, C, Che Mat, NF, Ma, W, Kumar, A. The IL-12 family of cytokines in infection, inflammation and autoimmune disorders. Inflamm Allergy Drug Targets 2009; 8: 40–52.Google Scholar
37. Shimizu, M, Shimamura, M, Owaki, T, et al. Antiangiogenic and antitumor activities of IL-27. J Immunol 2006; 176: 7317–7324.CrossRefGoogle ScholarPubMed