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Assessment of the relationship between serum magnesium levels, patent ductus arteriosus, and other neonatal morbidities: a retrospective observational study

Published online by Cambridge University Press:  14 April 2025

Selma Aktas Open the ORCID record for Selma Aktas [Opens in a new window] ,
Eda Albayrak ,
Osman Guvenc Open the ORCID record for Osman Guvenc [Opens in a new window] ,
Ebru Kazanci ,
Aysegul Inamlik ,
Ayse Pelin Ozcan ,
Ayse Korkmaz  and
Serdar Beken
Selma Aktas*
Affiliation:
Faculty of Medicine, Department of Pediatrics, Division of Neonatology, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
Eda Albayrak
Affiliation:
Department of Pediatrics, Acibadem Atakent Hospital, Istanbul, Turkey
Osman Guvenc
Affiliation:
Department of Pediatrics, Division of Pediatric Cardiology, Acibadem Atakent Hospital, Istanbul, Turkey
Ebru Kazanci
Affiliation:
Department of Pediatrics, Division of Neonatology, Acibadem Maslak Hospital, Istanbul, Turkey
Aysegul Inamlik
Affiliation:
Faculty of Medicine, Department of Pediatrics, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
Ayse Pelin Ozcan
Affiliation:
Faculty of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Turkey
Ayse Korkmaz
Affiliation:
Faculty of Medicine, Division of Neonatology, Department of Pediatrics, Mehmet Ali Aydınlar University, Istanbul, Turkey
Serdar Beken
Affiliation:
Faculty of Medicine, Division of Neonatology, Department of Pediatrics, Mehmet Ali Aydınlar University, Istanbul, Turkey
*
Corresponding author: Selma Aktas; Email: [email protected]
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Abstract

Objective:

This study aimed to evaluate the association between serum magnesium levels and the risk of symptomatic patent ductus arteriosus in premature infants.

Material and Method:

This retrospective single-centre cohort study analysed the medical records of patients. Neonates were categorised into two groups based on the presence or absence of symptomatic patent ductus arteriosus. Demographic factors including gender, gestational age, type of birth, birth weight, multiple pregnancies, medical treatment for duct closure or surgical ligation, length of hospital stay, and mortality and neonatal outcomes were compared between the groups. The relationship between serum magnesium levels at 24 hours of age and the risk of symptomatic patent ductus arteriosus and other neonatal morbidities was assessed.

Results:

This study found no significant relationship between symptomatic patent ductus arteriosus and serum magnesium levels. Additionally, no significant differences were observed between serum magnesium levels and ductal diameter, nor in the need for medical or surgical intervention for symptomatic patent ductus arteriosus. However, neonates with serum magnesium levels greater than 3 mg/dL exhibited a significantly higher incidence of respiratory distress syndrome. Conversely, the prevalence of bronchopulmonary dysplasia was significantly lower in this group, with both findings reaching statistical significance (p < 0.05)

Conclusion:

These results suggest that while serum magnesium levels may not be a reliable marker for symptomatic patent ductus arteriosus, they could have clinical implications in the modulation of neonatal respiratory outcomes. Further research is warranted to explore the underlying mechanisms and assess the potential therapeutic role of magnesium in the management of neonatal morbidities.

Keywords

Serum magnesium levelpatent ductus arteriosuspreterm infant
Type
Original Article
Information
Cardiology in the Young , First View , pp. 1 - 5
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Copyright
© The Author(s), 2025. Published by Cambridge University Press

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