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Assessment of the effects of physiological release of melatonin on arterial distensibility and blood pressure

Published online by Cambridge University Press:  01 April 2009

Mustafa Yildiz  and
Osman Akdemir
Mustafa Yildiz*
Affiliation:
Department of Cardiology, Kartal Kosuyolu Yuksek Ihtisas Educational and Research Hospital, Istanbul, Turkey
Osman Akdemir
Affiliation:
Department of Cardiology, Acibadem Health Care Group, Istanbul, Turkey
*
Correspondence to: Dr Mustafa Yildiz, Bayar Cad., Gülbahar Sok., Emniyet Sitesi No:11, A Blok A Kapısı Daire 6, Kozyatagi-Istanbul, Turkey. Tel: 90 532 371 17 01; Fax: 90 216 459 63 21; E-mail: [email protected]
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Abstract

Aim

The aim of our study was to investigate the effects of endogenous melatonin on arterial distensibility using measurements of the velocity of the aortic pulse wave between the carotid and femoral arteries in healthy young students assessed in the supine position.

Material and methods

We studied 29 healthy young students, aged between 18 and 27 years, with 19 being male. The measured the velocity of the aortic pulse wave between the carotid and femoral arteries, along the blood pressures and heart rate, while the subjects were in the supine position at two time points, namely from 01.30–02.30 and 13:30–14:30 hours, during a day, also taking plasma to measure the concentrations of melatonin. The velocity of the pulse waves was determined using an automatic device, the Complior Colson (France), which allowed on-line recording and automatic calculation of the velocity, the calculations being made by measuring the transit time of the pulse wave as it traversed the distance between two sites of recording according, the velocity of the pulse wave in meter per second being equal to the distance in meters divided by the time of transit in seconds.

Results

Although the velocity of the pulse wave, systolic, diastolic, and mean blood pressures, and heart rate were all increased in the morning relative to measurement made later in the day, levels of melatonin in the plasma were increased in the night. There was negative correlation between diurnal levels of melatonin and the velocity of the pulse wave.

Conclusion

Our findings indicate that increased levels of melatonin during the night may cause a decreased velocity of the aortic pulse wave, along with blood pressures and heart rate.

Keywords

Pulse wave velocitydiurnal rhythm
Type
Original Article
Information
Cardiology in the Young , Volume 19 , Issue 2 , April 2009 , pp. 198 - 203
Copyright
Copyright © Cambridge University Press 2009

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References

1.Asmar, R, Benetos, A, Topouchian, J, et al. Assessment of arterial distensibility by automatic pulse wave velocity measurement. Validation and clinical application studies. Hypertension 1995; 26: 485–490.CrossRefGoogle ScholarPubMed
2.Stefanadis, C, Wooley, CF, Bush, CA, Kolibash, AJ, Boudoulas, H. Aortic distensibility abnormalities in coronary artery disease. Am J Cardiol 1987; 59: 1300–1304.CrossRefGoogle ScholarPubMed
3.Dart, A, Silagy, C, Dewar, E, Jennings, G, McNeil, J. Aortic distensibility and left ventricular structure and function in isolated systolic hypertension. Eur Heart J 1993; 14: 1465–1470.CrossRefGoogle ScholarPubMed
4.Panza, JA, Epstein, SE, Quyyumi, AA. Circadian variation in vascular tone and its relation to alpha-sympathetic vasoconstrictor activity. N Engl J Med 1991; 325: 986–990.CrossRefGoogle ScholarPubMed
5.Weitzman, ED, Fukushima, D, Nogeire, C, Roffwarg, H, Gallagher, TF, Hellman, L. Twenty-four hour pattern of the episodic secretion of cortisol in normal subjects. J Clin Endocrinol Metab 1971; 33: 14–22.CrossRefGoogle ScholarPubMed
6.Scheer, FA, van Doornen, LJ, Buijs, RM. Light and diurnal cycle affect human heart rate: possible role for the circadian pacemaker. J Biol Rhythms 1999; 14: 202–212.CrossRefGoogle ScholarPubMed
7.Fourtillan, JB, Brisson, AM, Fourtillan, M, Ingrand, I, Decourt, JP, Girault, J. Melatonin secretion occurs at a constant rate in both young and older men and women. Am J Physiol Endocrinol Metab 2001; 280: E11–E22.CrossRefGoogle Scholar
8.Wang, M, Yokotani, K, Nakamura, K, Murakami, Y, Okada, S, Osumi, Y. Melatonin inhibits the central sympatho-adrenomedullary outflow in rats. Jpn J Pharmacol 1999; 81: 29–33.CrossRefGoogle ScholarPubMed
9.Mangoni, AA, Mircoli, L, Giannattasio, C, Mancia, G, Ferrari, AU. Effect of sympathectomy on mechanical properties of common carotid and femoral arteries. Hypertension 1997; 30: 1085–1088.CrossRefGoogle ScholarPubMed
10.Bergel, DH. The dynamic elastic properties of the arterial wall. J Physiol (Lond) 1961; 156: 458–469.CrossRefGoogle ScholarPubMed
11.Cox, RH. Effects of norepinephrine on mechanics of arteries in vivo. Am J Physiol 1976; 231: 420–425.CrossRefGoogle Scholar
12.Boutouyrie, P, Lacolley, P, Girerd, X, Beck, L, Safar, M, Laurent, S. Sympathetic activation decreases medium sized arterial compliance in humans. Am J Physiol 1994; 267: H1368–H1377.Google ScholarPubMed
13.Giannattasio, C, Mangoni, AA, Stella, ML, Carugo, S, Grassi, G, Mancia, G. Acute effects of smoking on radial artery compliance in humans. J Hypertens 1994; 12: 691–696.CrossRefGoogle ScholarPubMed
14.Baumbach, GL, Heistad, DD, Siemens, JE. Effects of sympathetic nerves on composition and distensibility of cerebral arterioles in rats. J Physiol (Lond) 1989; 416: 123–140.CrossRefGoogle ScholarPubMed
15.Grassi, G, Giannattasio, C, Failla, M, et al. Sympathetic modulation of radial artery compliance in congestive heart failure. Hypertension 1995; 26: 348–354.CrossRefGoogle ScholarPubMed
16.Asmar, R, Rudnichi, A, Blacher, J, London, GM, Safar, ME. Pulse pressure and aortic pulse wave are markers of cardiovascular risk in hypertensive populations. Am J Hypertens 2001; 14: 91–97.CrossRefGoogle ScholarPubMed
17.Moens, AI. Die Pulskurve. E.J. Brill, Leiden, 1878, p 90.Google Scholar
18.Korteweg, DJ. Über die Fortpflanzungsgeschwindigkeit des Schalles in elastischen Röhren. Ann Phys Chem Neue Folge 1878; 5: 225.Google Scholar
19.Bramwell, JC, Hill, AV. The velocity of the pulse wave in man. Proc R Soc Lond (Biol) 1922; 93: 298–306.Google Scholar
20.Boivin, D, Duffy, J, Kronauer, R, Czeisler, C. Dose-response relationships for resetting of human circadian clock by light. Nature 1996; 379: 540–542.CrossRefGoogle ScholarPubMed
21.Manninen, V, Huttunen, JK, Heinonen, OP, Tenkanen, L, Frick, MH. Relationships between baseline lipid and lipoprotein values and the incidence of coronary heart disease in the Helsinki Heart Study. Am J Cardiol 1989; 63: 42H–47H.CrossRefGoogle Scholar
22.Anuurad, E, Shiwaku, K, Nogi, A, et al. The new BMI criteria for asians by the regional office for the western pacific region of WHO are suitable for screening of overweight to prevent metabolic syndrome in elder Japanese workers. J Occup Health 2003; 45: 335–343.CrossRefGoogle ScholarPubMed
23.Smulyan, H, Marchais, SJ, Pannier, B, Guerin, AP, Safar, ME, London, GM. Influence of body height on pulsatile arterial hemodynamic data. JACC 1998; 31: 1103–1109.CrossRefGoogle ScholarPubMed
24.Elzinga, G, Westerhof, N. Matching between ventricle and arterial load: an evolutionary process. Circ Res 1991; 68: 1495–1500.CrossRefGoogle ScholarPubMed
25.London, GM, Guerin, AP, Pannier, B, Marchais, SJ, Stimpel, M. Influence of sex on arterial hemodynamics and blood pressure: role of body height. Hypertension 1995; 26: 514–519.CrossRefGoogle ScholarPubMed
26.Hayward, CS, Kelly, RP. Gender-related differences in the central arterial pressure waveform. JACC 1997; 30: 1863–1871.CrossRefGoogle ScholarPubMed
27.Smulyan, H, Asmar, RG, Rudnicki, A, London, G, Safar, M. Comparative effects of aging in men and women on the properties of the arterial tree. JACC 2001; 37: 1374–1380.CrossRefGoogle ScholarPubMed
28.Sudhir, K, Jennings, GL, Funder, JW, Komesaroff, PA. Estrogen enhances basal nitric oxide release in the forearm vasculature in perimenopausal women. Hypertension 1996; 28: 330–334.CrossRefGoogle ScholarPubMed
29.Bodlaj, G, Berg, J, Biesenbach, G. Diurnal variation of pulse wave velocity assessed non-invasively by applanation tonometry in young healthy men. Yonsei Med J 2007; 48: 665–670.CrossRefGoogle ScholarPubMed
30.Bodlaj, G, Berg, J, Biesenbach, G. Diurnal variation of arterial stiffness and subendocardial perfusion noninvasively assessed using applanation tonometry in healthy young men. Wien Klin Wochenschr 2005; 117: 348–352.CrossRefGoogle ScholarPubMed
31.Learoyd, BM, Taylor, MG. Alteration with age in the viscoelastic properties of human arterial walls. Circ Res 1966; 18: 278–292.CrossRefGoogle ScholarPubMed
32.Olivetti, G, Anversa, P, Melissari, M, Loud, AV. Morphometry of medial hypertrophy in the rat thoracic aorta. Lab Invest 1980; 42: 559–565.Google ScholarPubMed
33.Blacher, J, Asmar, R, Djane, S, London, GM, Safar, ME. Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension 1999; 33: 1111–1117.CrossRefGoogle ScholarPubMed
34.Mackenzie, S, Wilkinson, IB, Cockcroft, JR. Assessment of arterial stiffness in clinical practice. Q J Med 2002; 95: 67–74.CrossRefGoogle ScholarPubMed
35.Albaladejo, P, Copie, X, Boutouyrie, P, et al. Heart rate, arterial stiffness, and wave reflections in paced patients. Hypertension 2001; 38: 949–952.CrossRefGoogle ScholarPubMed
36.Yildiz, M, Sahin, B, Sahin, A. Acute effects of oral melatonin administration on arterial distensibility, as determined by carotid-femoral pulse wave velocity, in healthy young men. Exp Clin Cardiol 2006; 11: 311–313.Google ScholarPubMed
37.Arangino, S, Cagnacci, A, Angiolucci, M, et al. Effects of melatonin on vascular reactivity, catecholamine levels, and blood pressure in healthy men. Am J Cardiol 1999; 83: 1417–1419.CrossRefGoogle ScholarPubMed
38.Abete, P, Bianco, S, Calabrese, C, et al. Effects of melatonin in isolated rat papillary muscle. FEBS Letters 1997; 412: 79–85.CrossRefGoogle ScholarPubMed