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Anaphylactic reaction to anakinra in a child with steroid-dependent idiopathic recurrent pericarditis and successful management with canakinumab

Published online by Cambridge University Press:  01 April 2019

Serdar Epçaçan Open the ORCID record for Serdar Epçaçan [Opens in a new window] ,
Sezgin Sahin Open the ORCID record for Sezgin Sahin [Opens in a new window]  and
Ozgur Kasapcopur
Serdar Epçaçan
Affiliation:
Department of Pediatric Cardiology, Van Training and Research Hospital, University of Health Sciences, Van, Turkey
Sezgin Sahin*
Affiliation:
Department of Pediatric Cardiology, Van Training and Research Hospital, University of Health Sciences, Van, Turkey
Ozgur Kasapcopur
Affiliation:
Department of Pediatric Rheumatology, Van Training and Research Hospital, University of Health Sciences, Van, Turkey Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey
*
Author for correspondence: Sezgin Şahin, MD, Department of Pediatric Rheumatology, Van Training and Research Hospital, University of Health Sciences, 65100, Edremit, Van, Turkey. Tel: +90 506 770 57 28; Email: [email protected]
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Abstract

Conventional algorithm for treatment of pericarditis and prevention of recurrences consists of non-steroid anti-inflammatory drugs and/or colchicine, followed by corticosteroids in resistant patients. Anakinra has emerged as a promising and safe treatment modality for steroid-dependent idiopathic recurrent pericarditis. However, the efficacy and safety of canakinumab, another anti-interleukin-1 agent, has not been assessed up to date. Herein, we present development of an anaphylactic reaction due to anakinra and a successful subsequent treatment with canakinumab for the first time in the literature.

Keywords

Idiopathic recurrent pericarditistreatmentanti-IL 1 agents
Type
Brief Report
Information
Cardiology in the Young , Volume 29 , Issue 4 , April 2019 , pp. 549 - 551
Copyright
© Cambridge University Press 2019 

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References

Lazaros, G, Antonatou, K, Vassilopoulos, D. The therapeutic role of Interleukin-1 inhibition in idiopathic recurrent pericarditis: current evidence and future challenges. Front Med 2017; 4: 78.CrossRefGoogle ScholarPubMed
Brucato, A, Emmi, G, Cantarini, L, et al. Management of idiopathic recurrent pericarditis in adults and in children: a role for interleukin-1 receptor antagonism. Intern Emerg Med 2018; 13: 475–489.CrossRefGoogle Scholar
Imazio, M, Brucato, A, Pluymaekers, N, et al. Recurrent pericarditis in children and adolescents: a multicentre cohort study. J Cardiovasc Med 2016; 17: 707–712.CrossRefGoogle ScholarPubMed
Tarantino, G, Delogu, AB, De Rosa, G, Rigante, D. A possible still role for colchicine in children with idiopathic recurrent acute pericarditis? Intern Emerg Med 2018; 14: 331–332. doi: 10.1007/s11739-018-1997-5 CrossRefGoogle ScholarPubMed
Rodriguez-Gonzalez, M, Ruiz-Gonzalez, E, Castellano-Martinez, A. Anakinra as rescue therapy for steroid-dependent idiopathic recurrent pericarditis in children: case report and literature review. Cardiol Young 2018; 29: 241–243.CrossRefGoogle ScholarPubMed
Brucato, A, Imazio, M, Gattorno, M, et al. Effect of anakinra on recurrent pericarditis among patients with colchicine resistance and corticosteroid dependence: the AIRTRIP randomized clinical trial. JAMA 2016; 316: 1906–1912.CrossRefGoogle ScholarPubMed
Picco, P, Brisca, G, Traverso, F, Loy, A, Gattorno, M, Martini, A. Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease? Arthritis Rheum 2009; 60: 264–268.CrossRefGoogle ScholarPubMed
Sambola, A, Roca Luque, I, Merce, J, et al. Colchicine administered in the first episode of acute idiopathic pericarditis: a randomized multicenter open-label study. Rev Esp Cardiol (Engl Ed) 2019; pii: S1885-5857(18)30496-1. doi: 10.1016/j.rec.2018.11.016 [Epub ahead of print].Google ScholarPubMed
Lazaros, G, Vasileiou, P, Koutsianas, C, et al. Anakinra for the management of resistant idiopathic recurrent pericarditis. Initial experience in 10 adult cases. Ann Rheum Dis 2014; 73: 2215–2217.CrossRefGoogle ScholarPubMed
Finetti, M, Insalaco, A, Cantarini, L, et al. Long-term efficacy of interleukin-1 receptor antagonist (anakinra) in corticosteroid-dependent and colchicine-resistant recurrent pericarditis. J Pediatr 2014; 164: 1425–1431.CrossRefGoogle ScholarPubMed