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Anaphylactic reaction to anakinra in a child with steroid-dependent idiopathic recurrent pericarditis and successful management with canakinumab

Published online by Cambridge University Press:  01 April 2019

Serdar Epçaçan Open the ORCID record for Serdar Epçaçan [Opens in a new window] ,
Sezgin Sahin Open the ORCID record for Sezgin Sahin [Opens in a new window]  and
Ozgur Kasapcopur
Serdar Epçaçan
Affiliation:
Department of Pediatric Cardiology, Van Training and Research Hospital, University of Health Sciences, Van, Turkey
Sezgin Sahin*
Affiliation:
Department of Pediatric Cardiology, Van Training and Research Hospital, University of Health Sciences, Van, Turkey
Ozgur Kasapcopur
Affiliation:
Department of Pediatric Rheumatology, Van Training and Research Hospital, University of Health Sciences, Van, Turkey Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey
*
Author for correspondence: Sezgin Şahin, MD, Department of Pediatric Rheumatology, Van Training and Research Hospital, University of Health Sciences, 65100, Edremit, Van, Turkey. Tel: +90 506 770 57 28; Email: [email protected]
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Abstract

Conventional algorithm for treatment of pericarditis and prevention of recurrences consists of non-steroid anti-inflammatory drugs and/or colchicine, followed by corticosteroids in resistant patients. Anakinra has emerged as a promising and safe treatment modality for steroid-dependent idiopathic recurrent pericarditis. However, the efficacy and safety of canakinumab, another anti-interleukin-1 agent, has not been assessed up to date. Herein, we present development of an anaphylactic reaction due to anakinra and a successful subsequent treatment with canakinumab for the first time in the literature.

Keywords

Idiopathic recurrent pericarditistreatmentanti-IL 1 agents
Type
Brief Report
Information
Cardiology in the Young , Volume 29 , Issue 4 , April 2019 , pp. 549 - 551
Copyright
© Cambridge University Press 2019 

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