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Absence of association of FCGR2A gene polymorphism rs1801274 with Kawasaki disease in Greek patients

Published online by Cambridge University Press:  28 April 2014

Anthoula Chatzikyriakidou ,
Louiza Aidinidou ,
Andreas Giannopoulos ,
Kyriaki Papadopoulou-Legbelou ,
Kallirhoe Kalinderi  and
Liana Fidani
Anthoula Chatzikyriakidou
Affiliation:
Department of General Biology, Medical School, Aristotle University of Thessaloniki, Greece
Louiza Aidinidou
Affiliation:
Department of General Biology, Medical School, Aristotle University of Thessaloniki, Greece
Andreas Giannopoulos
Affiliation:
2nd Department of Pediatric, Pediatric Cardiology Clinic, Ahepa University Hospital, Aristotle University of Thessaloniki, Greece
Kyriaki Papadopoulou-Legbelou
Affiliation:
4th Department of Paediatrics, Papageorgiou General Hospital, Aristotle University of Thessaloniki, Greece
Kallirhoe Kalinderi
Affiliation:
Department of General Biology, Medical School, Aristotle University of Thessaloniki, Greece
Liana Fidani*
Affiliation:
Department of General Biology, Medical School, Aristotle University of Thessaloniki, Greece
*
Correspondence to: L. Fidani, Department of General Biology, Medical School, Aristotle University of Thessaloniki, GR-54124, Thessaloniki, Greece. Tel.: +30 2310999165; Fax: +30 2310999019; E-mail: [email protected]
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Abstract

Kawasaki disease is an acute, febrile syndrome in infancy, characterised by vasculitis of medium-sized arteries, and affects predominantly young children. Family-based studies on Kawasaki disease supports the contribution of genetic factors in disorder manifestation. In a recent genome-wide association study, the polymorphism rs1801274 of FCGR2A [Fc fragment of immunoglobulin G, low-affinity IIa, receptor] gene has been implicated in disease pathogenesis. The aim of the present study was to explore the association of this variant, for the first time, in a group of Kawasaki-diseased patients of Greek origin. A total of 47 Kawasaki-diseased children and 50 control subjects were enrolled in the study. Polymerase chain reaction–restriction fragment length polymorphism assay was performed in rs1801274 genotyping. No association was observed between this polymorphism genotypes’ or alleles’ distribution between Kawasaki-diseased patients and controls. Furthermore, no association was revealed between this polymorphism and cardiovascular complications in Kawasaki-diseased patients. In the literature, the reported data over this polymorphism association with Kawasaki disease in Caucasian patients are contradictory. In addition, the disease shows low prevalence in the Caucasian populations. Therefore, the independent genetic association studies on rs1801274 with Kawasaki disease in various Caucasian groups increase the amount of genetic data, which could be used in a future meta-analysis, increasing the statistical power of the resultant conclusions.

Keywords

Kawasaki diseaseFCGR2A genepolymorphism
Type
Original Articles
Information
Cardiology in the Young , Volume 25 , Issue 4 , April 2015 , pp. 681 - 683
Copyright
© Cambridge University Press 2014 

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