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Takotsubo cardiomyopathy: how much do we know of this syndrome in children and young adults?

Published online by Cambridge University Press:  13 February 2014

Lazaro E. Hernandez*
Affiliation:
Department of Pediatrics, University of Minnesota, Amplatz Children Hospital, Minnesota, United States of America
*
Correspondence to: Dr L. E. Hernandez, MD, Department of Pediatrics, University of Minnesota Amplatz Children’s Hospital, Minnesota, United States of America. Tel: +612 626 2755; Fax: +612 626 2467; E-mail: [email protected]

Abstract

Since Takotsubo cardiomyopathy was first described by Sato in 1990, multiple cases have been reported, but only few in children, among whom this type of cardiomyopathy is to some extent underappreciated. A series of children with this syndrome were therefore reviewed, drawing comparison with cases reported by others. The review addresses the current challenges in diagnosis, presentation, triggers, clinical course, management, and possible pathogenic mechanisms of the entity.

Type
Review Articles
Copyright
© Cambridge University Press 2014 

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References

1. Sato, H, Tateishi, H, Uchida, T, et al. Clinical aspect of myocardial injury from ischemia to heart failure. Kagakuhyouronsya, Tokyo, 1990: 5664.Google Scholar
2. Bielecka-Dabrowa, A, Mikhailidis, DP, Hannam, S. Takotsubo cardiomyopathy – the current stage of knowledge. Int J Cardiol 2010; 142: 120125.CrossRefGoogle Scholar
3. Bounhoure, JP. Takotsubo or stress cardiomyopathy. Cardiov Psychaitr Neurol 2012: 1–4, doi:10.1155/2012/637672.Google Scholar
4. Maron, BJ, Towbin, JA, Thiene, G, et al. Contemporary definition and classification of cardiomyopathies: An American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and Functional Genomics and Translational Biology Interdisciplinary Working Groups; and Council on Epidemiology and Prevention. Circulation 2006; 113: 18071816.CrossRefGoogle ScholarPubMed
5. Merchant, EE, Johnson, SW, Nguyen, P, et al. Takotsubo cardiomyopathy: a series and review of the literature. West J Emerg Med 2008; 2: 104111.Google Scholar
6. Lee, SY, Lee, SE, Choi, JW, et al. A case of transient left ventricular apical ballooning syndrome in a child: clinical features and imaging findings. Int J Cardiovasc Imaging 2010; 26: 345351.Google Scholar
7. Bajolle, F, Basquin, A, Lucron, H, et al. Acute ischemic cardiomyopathy after extreme emotional stress in a child. Congenit Heart Dis 2009; 4: 387390.Google Scholar
8. Dessardo, S, Tomulie, V, Dessardo, NS. Tako-tsubo syndrome in a 12-year-old girl: exhausted heart, no broken heart. Pediatr Cardiol 2011; 32: 10081011.Google Scholar
9. Biteker, M, Duran, NE, Civan, HA, et al. Broken heart syndrome in a 17-year-old-girl. Eur J Pediatr 2009; 168: 12731275.Google Scholar
10. Greco, CA, De Rito, V, Petracca, M, et al. Takotsubo syndrome in a newborn. J Am Soc Echo 2011; 24: 471.e5471.e7.CrossRefGoogle ScholarPubMed
11. Maruyama, S, Nomura, Y, Fukushige, T, et al. Suspected takotsubo cardiomyopathy caused by withdrawal of bupirenorphine in a child. Circ J 2006; 70: 509511.Google Scholar
12. Kapoor, D, Bybee, KA. Stress cardiomyopathy syndrome: a contemporary review. Curr Heart Fail Rep 2009; 6: 265271.CrossRefGoogle ScholarPubMed
13. Serra Carvalho, PM, Lima, JH, Cunha, JB. Tako-tsubo cardiomyopathy – the role of physical and emotional stressors: two case report. Int J Clin Med 2012; 3: 145150.Google Scholar
14. Sharkey, SW, Lesser, JR, Zenovich, AG, et al. Acute and reversible cardiomyopathy provoked by stress in women from the United States. Circ 2005; 4: 472479.CrossRefGoogle Scholar
15. De Rosa, G, Pardeo, M, Di Rocco, C, et al. Neurogenic stunned myocardium presenting as left ventricular trabeculation in childhood: a variant of takotsubo cardiomyopathy? Pediatr Crit Care Med 2011; 6: e420e423.CrossRefGoogle Scholar
16. Zorzi, A, Migliori, F, Perazzolo Marra, M, et al. Electrocardiographic J waves as a hyperacute sign of takotsubo syndrome. J Electr 2012; 45: 353356.CrossRefGoogle ScholarPubMed
17. Thygesen, K, Alpert, JS, White, HD. Joint ESC/ACCF/AHA/WHF task force for the redefinition of myocardial infarction. Universal definition of myocardial infarction. Eur Heart J 2007; 28: 2525.Google Scholar
18. Lim, W, Qushmaq, I, Devereaux, PJ, et al. Elevated cardiac troponin measurements in critical ill patients. Arch Intern Med 2006; 166: 2446.CrossRefGoogle Scholar
19. Gianni, M, Dentali, F, Grandi, AM, et al. Apical ballooning syndrome or takotsubo cardiomyopathy: a systematic review. Eur Heart J 2006; 27: 1523.Google Scholar
20. Sharkey, SW, Windenburg, DC, Lesser, JR, et al. Natural history and expansive clinical profile of stress (Tako-tsubo) cardiomyopathy. J Am Coll Cardiol 2010; 55: 333.Google Scholar
21. Soongswang, J, Durongpisitkul, K, Ratanarapee, S, et al. Cardiac troponin T: its role in the diagnosis of clinical suspected acute myocarditis and chronic dilated cardiomyopathy in children. Pediatr Cardiol 2002; 23: 531.Google Scholar
22. Jaguszewski, M, Osipova, J, Ghadri, JR, et al. A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from acute myocardial infection. Eur Heart J, 201. doi:10.1093/eurheartj/eht392.Google Scholar
23. Ako, J, Takenaka, K, Uno, K, et al. Reversible left ventricular systolic dysfunction-reversibility of coronary microvascular abnormality. Jpn Heart J 2001; 42: 355363.CrossRefGoogle ScholarPubMed
24. Park, SM, Prasad, A, Rihal, C, et al. Left ventricular systolic and diastolic function in patients with apical ballooning syndrome compare with patients with anterior ST-segment elevation myocardial infarction: a functional paradox. Mayo Clin Proc 2009; 84: 514521.Google Scholar
25. Kurowski, V, Kaiser, A, Von Hof, K, et al. Apical and mid ventricular left ventricular dysfunction syndrome (Tako-tsubo cardiomyopathy): frequency, mechanism, and prognosis. Chest 2007; 132: 809.Google Scholar
26. Haghi, D, Athanasiadis, A, Papavassiliu, T, et al. Right ventricular involvement in takotsubo cardiomyopathy. Eur Heart J 2006; 27: 2433.Google Scholar
27. Rolf, A, Nef, HM, Mollmann, H. Immunohistolical bases of the late gadolinium enhancement phenomenon if tako-tsubo cardiomyopathy. Eur Heart J. 2009; 30: 16351642.Google Scholar
28. Eitel, I, Behrendt, K, Schindler, K, et al. Differential diagnosis of suspected apical ballooning syndrome using contrast-enhanced magnetic resonance imaging. Eur Heart J 2008; 29: 26512659.CrossRefGoogle ScholarPubMed
29. Richard, C. Stress-related cardiomyopathies. Ann Intensive Care 2011; 1: 39.Google Scholar
30. Bybee, KA, Kara, T, Prasad, A, et al. Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann Int Med 2004; 141: 858865.Google Scholar
31. Caussin, C, Ohanessian, A, Lancelin, B, et al. Coronary plaque burden detected by multislice computed tomography after acute myocardial infarction with near-normal coronary arteries by angiography. Am J Cardiol 2003; 92: 849852.Google Scholar
32. Ibanez, B, Navarro, F Cordoba, M, et al. Tako-tsubo transient left ventricular apical ballooning: is intravascular ultrasound the key to resolve the enigma? Heart 2005; 91: 102104.Google Scholar
33. Kurisu, S, Inoue, I, Kawagoe, T, et al. Prevalence of incidental coronary artery disease in tako-tsubo cardiomyopathy. Coron Artery Dis 2009; 20: 214218.Google Scholar
34. Kono, T, Sabbah, HN. Takotsubo cardiomyopathy. Heart Fail Rev 2013: 1–9, doi:10.1007/s10741-013-9404-9.Google Scholar
35. Hernandez, LE, Martinez, Y, Chan, KC. Takotsubo cardiomyopathy: an unusual cardiomyopathy at an unusual age. Cardiol Young 2010; 20: 577579.Google Scholar
36. Miyachi, H, Kumita, SI, Tanaka, K. PET/CT and SPECT/CT cardiac fusion imaging in a patient with takotsubo cardiomyopathy. Eur Heart J 2013; 34: 397.Google Scholar
37. Akashi, YJ, Goldstein, DS, Barbaro, G, et al. Takotsubo cardiomyopathy: a new form of acute, reversible heart failure. Circulation 2008; 118: 27542762.Google Scholar
38. Abraham, J, Mudd, JO, Kapur, N, et al. Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists. J Am Coll Cardiol 2009; 53: 13201325.Google Scholar
39. Wittstein, IS, Thiemann, DR, Lima, JAC, et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N Engl J Med 200; 352: 539548.CrossRefGoogle Scholar
40. Mohaveh, A, Reeves, WC, Metha, PM, et al. Norepinephrine-induced left ventricular dysfunction in anesthetized and conscious, sedated dogs. Int J Cardiol, 45: 2333.Google Scholar
41. Frustaci, A, Loperfido, F, Gebtiloni, N, et al. Cathecolamine-induced cardiomyopathy in multiple endocrine neoplasia. A histologic, ultrastructural, and biochemical study. Chest, 99: 382385.CrossRefGoogle Scholar
42. Shaw, TR, Rafferty, P, Tait, GW. Transient shock and myocardial impairment caused by phaeochromocytoma crisis. Br Heart J 1987; 57: 194198.Google Scholar
43. Mayer, SA, Lin, J, Homma, S, et al. Myocardial injury and left ventricular performance after subarachnoid hemorrhage. Stroke 1999; 30: 780786.CrossRefGoogle ScholarPubMed
44. Masuda, T, Sato, K, Yamamoto, S, et al. Sympathetic nervous activity and myocardial damage immediately after subarachnoid hemorrhage in a unique animal model. Stroke 2002; 33: 16711676.Google Scholar
45. Huang, MT, Lee, CF, Dobson, GP. Epinephrine enhances glycogen turnover and depress glucose uptake in vivo in rat heart. FASEB J, 11: 973980.CrossRefGoogle Scholar
46. Nef, HM, Mollmann, H, Kostin, S, et al. Tako-tsubo cardiomyopathy: intraindividual structural analysis in the acute phase and after functional recovery. Eur Heart J 2007; 28: 24562464.CrossRefGoogle ScholarPubMed
47. Lacy, CR, Contracta, RJ, Robbins, ML, et al. Coronary vasoconstriction induced by mental stress (simulated public speaking). Am J Cardiol 1995; 75: 503505.CrossRefGoogle ScholarPubMed
48. Elesber, A, Lerman, A, Bybee, KA, et al. Myocardial perfusion in apical ballooning syndrome correlate of myocardial injury. Am Heart J 2006; 152: 469.e9469.e13.Google Scholar
49. Galiuto, L, De Caterina, AR, Porfidia, A, et al. Reversible coronary microvascular dysfunction: a common pathogenic mechanism in apical ballooning or tako-tsubo syndrome. Eur Heart J 2010; 31: 13191327.Google Scholar
50. Kurisu, S, Inoue, I, Kawagoe, T, et al. Myocardial perfusion and fatty acid metabolism in patients with takotsubo-like left ventricular dysfunction. J Am Coll Cardiol 2003; 41: 743748.Google Scholar
51. Gerbaud, E, Montaudon, M, Leroux, L, et al. MRI for the diagnosis of left ventricular apical ballooning syndrome (LVABS). Eur Radiol 2008; 18: 947954.CrossRefGoogle ScholarPubMed
52. Nef, HM, Mollmann, H, Elsasser, A. Tako-tsubo cardiomyopathy (apical ballooning). Heart 2007; 93: 13091315.Google Scholar
53. Brewington, SD, Abbas, AA, Dixon, SR, et al. Reproducible microvascular dysfunction with dobutamine infusion in takotsubo cardiomyopathy presenting with ST segment elevation. Catheter Cardiovasc Interv 2006; 68: 769774.CrossRefGoogle ScholarPubMed
54. Ueyama, T, Hano, T, Kasamatsu, K, et al. Estrogen attenuates the emotional stress-induced cardiac responses in the animal model of tako-tsubo (Ampulla) cardiomyopathy. J Cardiovasc Pharmacol 2003; 42 (Suppl 1): S117S119.CrossRefGoogle ScholarPubMed
55. Sader, MA, Celermajer, DS. Endothelial function, vascular reactivity and gender differences in the cardiovascular system. Cardiovasc Res 2002; 53: 597604.Google Scholar
56. Ueyama, T, Kasamatsu, K, Hano, T, et al. Catecholamines and estrogen are involved in the pathogenesis of emotional stress-induced acute heart attack. Ann NY Acad Sci 2008; 1148: 479485.CrossRefGoogle ScholarPubMed
57. Fabi, M, Testa, G, Gesuete, V, et al. An unusual cardiomyopathy after physical stress in a child. Congenit Heart Dis 2013; 8: E45E48.CrossRefGoogle ScholarPubMed
58. Berton, E, Vitali-Serdoz, L, Vallon, P, et al. Young girl apical ballooning heart syndrome. Int J Cardiol 2012; 161: e4e6.Google Scholar
59. Yoshioka, T, Hashimoto, A, Tsuchihashi, K, et al. Clinical implications of midventricular obstruction and intravenous propranolol use in transient left ventricular apical ballooning (Tako-tsubo cardiomyopathy). Am Heart J 2008; 155: 526.e1526.e7.Google Scholar
60. Kurowski, V, Radke, PW, Schunkert, H, et al. Patient care in the acute phase of stress induced cardiomyopathy (Tako-tsubo cardiomyopathy) and thereafter? Herz 2010; 35: 245250.Google Scholar
61. Haghi, D, Papavassiliu, T, Heggemann, F, et al. Incidence and clinical significance of left ventricular thrombus in tako-tsubo cardiomyopathy assessed with echocardiography. Q J Med 2008; 101: 381386.Google Scholar
62. Schoof, S, Bertram, H, Hohmann, D, et al. Takotsubo cardiomyopathy in a 2-year-old-girl. J Am Coll Cardiol 2010; 55: e5.Google Scholar
63. Ohwada, R, Hotta, M, Kimura, H, et al. Ampulla cardiomyopathy after hypoglycemia in three young female patients with anorexia nervosa. Intern Med 2005; 44: 228233.Google Scholar