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Takayasu’s disease: a review

Published online by Cambridge University Press:  01 June 2008

Oliver R. Tann ,
Robert M.R. Tulloh  and
Mark C.K. Hamilton
Oliver R. Tann*
Affiliation:
Department of Clinical Radiology, Bristol Royal Infirmary, Marlborough St. Bristol
Robert M.R. Tulloh
Affiliation:
Department of Paediatric Cardiology, Bristol Royal Hospital for Children, Bristol, United Kingdom
Mark C.K. Hamilton
Affiliation:
Department of Clinical Radiology, Bristol Royal Infirmary, Marlborough St. Bristol
*
Department of Clinical Radiology, Bristol Royal Infirmary, Marlborough St., Bristol BS2 8HW, United Kingdom. Tel: (0)117 928 2672; Fax: (0)117 928 3267; E-mail: [email protected]
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Abstract

Takayasu’s disease is a rare chronic vasculitis of unknown aetiology. Initial symptoms and signs are non-specific, and a high index of suspicion is needed to make the correct diagnosis. The disease is associated with a high incidence of morbidity, and a significant risk of premature death. Serological tests have proved unreliable in distinguishing active from quiescent disease, with non-invasive imaging currently offering the best option for early diagnosis, and monitoring the response to treatment. In this review, we detail the epidemiology, pathophysiology, clinical features, imaging characteristics, and currently available treatments.

Keywords

Arteritispathophysiologyimagingtreatment
Type
Review Article
Information
Cardiology in the Young , Volume 18 , Issue 3 , June 2008 , pp. 250 - 259
Copyright
Copyright © Cambridge University Press 2008

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References

1.Numano, F, Okawara, M, Inomata, H, Kobayashi, Y. Takayasu’s arteritis. The Lancet 2000; 356: 1023–1025.CrossRefGoogle ScholarPubMed
2.Dillon, MJ. Childhood Vasculitis. Lupus 1998; 74: 259–265.CrossRefGoogle Scholar
3.Hall, S, Barr, W, Lie, JT, Stanson, AW, Kazmier, FJ, Hunder, GG. Takayasu arteritis. A study of 32 North American patients. Medicine (Baltimore) 1985; 64: 89–99.CrossRefGoogle ScholarPubMed
4.Wilkinson, NM, Page, J, Uribe, AG, Espinosa, V, Cabral, DA. Establishment of a pilot pediatric registry for chronic vasculitis is both essential and feasible: a Childhood Arthritis and Rheumatology Alliance (CARRA) Survey. J Rheumatol 2007; 34: 224–226.Google ScholarPubMed
5.Lupi-Herrera, E, Sanchez-Torres, G, Marcushamer, J, Mispireta, J, Horowitz, S, Vela, JE. Takayasu’s arteritis. Clinical study of 107 cases. Am Heart J 1977; 93: 94–103.CrossRefGoogle ScholarPubMed
6.Ladhani, S, Tulloh, R, Anderson, D. Takayasu disease masquerading as interruption of the aortic arch in a 2 year old child. Cardiol Young 2001; 11: 231–233.CrossRefGoogle Scholar
7.Kerr, GS, Hallahan, CW, Giordano, J, et al. Takayasu arteritis. Ann Intern Med 1994; 120: 919–929.CrossRefGoogle ScholarPubMed
8.Jain, S, Sharma, N, Singh, S, Bali, HK, Kumar, L, Sharma, BK. Takayasu arteritis in children and young Indians. Int J Cardiol 2000; 75 Suppl 1: S153–157.CrossRefGoogle ScholarPubMed
9.Gravanis, MB. Giant cell arteritis and Takayasu aortitis: morphologic, pathogenetic and etiologic factors. Int J Cardiol 2000; 75 Suppl 1: S21–33; discussion S35–36.CrossRefGoogle ScholarPubMed
10.Morales, E, Pineda, C, Martinez-Lavin, M. Takayasu’s arteritis in children. J Rheumatol 1991; 18: 1081–1084.Google ScholarPubMed
11.Subramanyan, R, Joy, J, Balakrishnan, KG. Natural history of aortoarteritis (Takayasu’s disease). Circulation 1989; 80: 429–437.CrossRefGoogle ScholarPubMed
12.Seko, Y. Takayasu arteritis insights into immunopathology. Japan Heart J 2000; 41: 15–26.CrossRefGoogle ScholarPubMed
13.Sharma, S, Rajani, M, Talwar, KK. Angiographic morphology in nonspecific aortoarteritis (Takayasu’s arteritis): a study of 126 patients from north India. Cardiovasc Inervent Radiol 1992; 15: 160–165.CrossRefGoogle ScholarPubMed
14.Muranjan, MN, Bavdekar, SB, More, V, Deshmukh, H, Tripathi, M, Vaswani, R. Study of Takayasu’s arteritis in children: clinical profile and management. J Postgrad Med 2000; 46: 3–8.Google ScholarPubMed
15.Paul, JF, Hernigou, A, Lefebvre, C, et al. Electron beam CT features of the pulmonary artery in Takayasu’s arteritis. AJR 1999; 173: 89–93.CrossRefGoogle Scholar
16.Yamada, I, Shibuya, H, Matsubara, O, et al. Pulmonary artery disease in Takayasu’s arteritis: angiographic findings. AJR 1992; 159: 263–269.CrossRefGoogle ScholarPubMed
17.Yamato, M, Lecky, JW, Hiramatsu, K, Kohda, E. Takayasu arteritis: radiographic and angiographic findings in 59 patients. Radiology 1986; 161: 329–334.CrossRefGoogle ScholarPubMed
18.Matsubara, O, Kuwata, T, Nemoto, T, Kasuga, T, Numano, F. Coronary artery lesions in Takayasu arteritis: pathological considerations. Heart Vessels Suppl 1992; 7: 26–31.CrossRefGoogle ScholarPubMed
19.Wang, JZ. Neurological manifestation of Takayasu’s arteritis. Zhonghua Shen Jing Jing Shen Ke Za Zhi 1992; 25: 369–371; 385–386 (Article in Chinese).Google ScholarPubMed
20.Chun, YS, Park, SJ, Park, IK, Chung, H, Lee, J. The clinical and ocular manifestations of Takayasu arteritis. Retina 2001; 21: 132–140.CrossRefGoogle ScholarPubMed
21.Kaushik, S, Gupta, A, Gupta, V, Jain, S, Lal, V. Retinal arterial occlusion in Takayasu’s arteritis. Indian J Ophthalmol 2005; 53: 194–196.Google ScholarPubMed
22.Frances, C, Boisnic, S, Bletry, O, et al. Cutaneous manifestations of Takayasu arteritis. A retrospective study of 80 cases. Dermatologica 1990; 181: 266–272.CrossRefGoogle ScholarPubMed
23.Arend, WP, Michel, BA, Bloch, DA, et al. The American College of Rheumatology 1990 criteria for the classification of Takayasu arteritis. Arthritis Rheum 1990; 33: 1129–1134.CrossRefGoogle ScholarPubMed
24.Ishikawa, K. Natural history and classification of occlusive thromboaortopathy (Takayasu’s disease). Circulation 1978; 57: 27–35.CrossRefGoogle ScholarPubMed
25.Mishima, Y. Lerich Memorial Lecture at 24th World Congress. “Takayasu’s arteritis in Asia”. Cardiovasc Surg 2001; 9: 3–10.CrossRefGoogle Scholar
26.Ishikawa, K, Maetani, S. Long-term outcome for 120 Japanese patients with Takayasu’s disease. Clinical and statistical analyses of related prognostic factors. Circulation 1994; 90: 1855–1860.CrossRefGoogle ScholarPubMed
27.Hoffman, GS, Ahmed, AE. Surrogate markers of disease activity in patients with Takayasu arteritis. A preliminary report from The International Network for the Study of the Systemic Vasculitides. Int J Cardiol 19981; 66 Suppl 1: S191–194; discussion S195.CrossRefGoogle Scholar
28.Park, MC, Lee, SW, Park, YB, Lee, SK. Serum cytokine profiles and their correlations with disease activity in Takayasu’s arteritis. Rheumatology (Oxford) 2006; 45: 545–548.CrossRefGoogle ScholarPubMed
29.Berkmen, Y, Lande, A. Chest roentgenography as a window to the diagnosis of Takayasu’s arteritis. AJR 1975; 125: 842–846.CrossRefGoogle Scholar
30.Sharma, S, Rajani, M, Kamalakar, T, Kumar, A, Talwar, KK. The association between aneurysm formation and systemic hypertension in Takayasu’s arteritis. Clin Radiol 1990; 42: 182–187.CrossRefGoogle ScholarPubMed
31.Weiler, V, Redtenbacher, S, Bancher, C, Fischer, MB, Smolen, JS. Concurrence of sarcoidosis and aortitis: case report and review of the literature. Ann Rheum Dis 2000; 59: 850–853.CrossRefGoogle ScholarPubMed
32.Schmidt, WA, Nerenheim, A, Seipelt, E, Poehls, C, Gromnica-Ihle, E. Diagnosis of early Takayasu arteritis with sonography. Rheumatology 2002; 41: 496–502.CrossRefGoogle ScholarPubMed
33.Maeda, H, Handa, N, Matsumoto, M, et al. Carotid lesion detected by B-mode ultrasonography in Takayasu’s arteritis: ‘macaroni sign’ as an indicator of the disease. Ultrasound Med Biol 1991; 17: 695–701.CrossRefGoogle ScholarPubMed
34.Sun, Y, Yip, PK, Jeng, JS, Hwang, BS, Lin, WH. Ultrasonographic study and long-term follow-up of Takayasu’s arteritis. Stroke 1996; 27: 2178–2182.CrossRefGoogle ScholarPubMed
35.Gotway, MB, Araoz, PA, Macedo, TA, et al. Imaging findings in Takayasu’s arteritis. AJR 2005; 184: 1945–1950.CrossRefGoogle ScholarPubMed
36.Cantu, C, Pineda, C, Barinagarrementeria, F, et al. Noninvasive cerebrovascular assessment of Takayasu arteritis. Stroke 2000; 31: 2197–2202.CrossRefGoogle ScholarPubMed
37.Johnston, SL, Lock, RJ, Gompels, MM. Takayasu arteritis: a review. J Clin Pathol 2002; 55: 481–486.CrossRefGoogle ScholarPubMed
38.Park, JH, Han, MC, Kim, SH, Oh, BH, Park, YB, Seo, JD. Takayasu arteritis: angiographic findings and results of angioplasty. AJR 1989; 153: 1069–1074.CrossRefGoogle ScholarPubMed
39.Yoshida, S, Akiba, H, Tamakawa, M, et al. The spectrum of findings in supra-aortic Takayasu’s arteritis as seen on spiral CT angiography and digital subtraction angiography. Cardiovasc Intervent Radiol 2001; 24: 117–121.CrossRefGoogle ScholarPubMed
40.Numano, F. Pulmonary changes in Takayasu arteritis. Cardioangiol 1979; 6: 97–108 (In Japanese).Google Scholar
41.Park, JH, Chung, JW, Im, JG, Kim, SK, Park, YB, Han, MC. Takayasu arteritis: Evaluation of mural changes in the aorta and pulmonary artery with CT angiography. Radiology 1995; 196: 89–93.CrossRefGoogle ScholarPubMed
42.Hayashi, K, Fukushima, T, Matsunaga, N, Hombo, Z. Takayasu arteritis: Decrease in aortic wall thickening following steroid therapy, documented by CT. Br J Radiol 1986; 59: 281–283.CrossRefGoogle ScholarPubMed
43.Tanigawa, K, Eguchi, K, Kitamura, Y, et al. Magnetic resonance imaging detection of aortic and pulmonary artery wall thickening in the acute stage of Takayasu arteritis. Improvement of clinical and radiologic findings after steroid therapy. Arthritis Rheum 1992; 35: 476–480.CrossRefGoogle ScholarPubMed
44.Choe, YH, Han, BK, Koh, EM, Kim, DK, Do, YS, Lee, WR. Takayasu’s arteritis: assessment of disease activity with contrast-enhanced MR imaging. AJR 2000; 175: 505–511.CrossRefGoogle ScholarPubMed
45.Desai, MY, Stone, JH, Foo, TK, Hellmann, DB, Lima, JA, Bluemke, DA. Delayed contrast-enhanced MRI of the aortic wall in Takayasu’s arteritis: initial experience. AJR 2005; 184: 1427–1431.CrossRefGoogle ScholarPubMed
46.Andrews, J, Al-Nahhas, A, Pennell, DJ, et al. Non-invasive imaging in the diagnosis and management of Takayasu’s arteritis. Annals Rheumatic Dis 2004; 63: 995–1000.CrossRefGoogle ScholarPubMed
47.Nakamura, T, Hayashi, S, Fukuoka, M, Sueoka, N, Nagasawa, K. Pulmonary infarction as the initial manifestation of Takayasu’s arteritis. Intern Med 2006; 45: 725–728.CrossRefGoogle ScholarPubMed
48.Webb, M, Chambers, A, AL-Nahhas, A, et al. The role of 18F-FDG PET in characterising disease activity in Takayasu arteritis. Eur J Nucl Med Mol Imaging 2004; 31: 627–634.CrossRefGoogle ScholarPubMed
49.Kobayashi, Y, Ishii, K, Oda, K, et al. Aortic wall inflammation due to Takayasu arteritis imaged with 18F-FDG PET coregistered with enhanced CT. J Nucl Med 2005; 46: 917–922.Google ScholarPubMed
50.Davenport, AP, Kirkpatrick, PJ, Arch, BN, Pickard, JD, Weissberg, PL. Imaging atherosclerotic plaque inflammation with [18F]-fluorodeoxyglucose positron emission tomography. Circulation 2002; 105: 2708–2711.Google Scholar
51.Seyahi, E, Ugurlu, S, Cumali, R, et al. Atherosclerosis in Takayasu arteritis. Ann Rheum Dis 2006; 65: 1202–1207.CrossRefGoogle ScholarPubMed
52.Hoffman, GS, Leavitt, RY, Kerr, GS, Rottem, M, Sneller, MC, Fauci, AS. Treatment of glucocorticoid-resistant or relapsing Takayasu arteritis with methotrexate. Arthritis Rheum 1994; 37: 578–582.CrossRefGoogle ScholarPubMed
53.Ozen, S, Duzova, A, Bakkaloglu, A, et al. Takayasu arteritis in children: preliminary experience with cyclophosphamide induction and corticosteroids followed by methotrexate. J Pediatr 2007; 150: 72–76.CrossRefGoogle ScholarPubMed
54.Matsuyama, A, Sakai, N, Ishigami, M, Hiraoka, H, Yamashita, S. Minocycline for the treatment of Takayasu arteritis. Ann Intern Med 2005; 143: 394–395.CrossRefGoogle ScholarPubMed
55.Hoffman, GS, Merkel, PA, Brasington, RD, Lenschow, DJ, Liang, P. Anti-tumor necrosis factor therapy in patients with difficult to treat Takayasu arteritis. Arthritis Rheum 2004; 50: 2296–2304.CrossRefGoogle ScholarPubMed
56.Liang, P, Hoffman, GS. Advances in the medical and surgical treatment of Takayasu arteritis. Curr Opin Rheumatol 2005; 17: 16–24.CrossRefGoogle ScholarPubMed
57.Weaver, FA, Yellin, AE, Campen, DH, et al. Surgical procedures in the management of Takayasu’s arteritis. J Vasc Surg 1990; 12: 429–439.CrossRefGoogle ScholarPubMed
58.Tyagi, S, Verma, PK, Gambhir, DS, Kaul, UA, Saha, R, Arora, R. Early and long-term results of subclavian angioplasty in aortoarteritis (Takayasu disease): comparison with atherosclerosis. Cardiovasc Intervent Radiol 1998; 21: 219–224.CrossRefGoogle ScholarPubMed
59.Fava, MP, Foradori, GB, Garcia, CB, et al. Percutaneous transluminal angioplasty in patients with Takayasu arteritis: five year experience. J Vasc Interv Radiol 1993; 4: 649–652.CrossRefGoogle ScholarPubMed
60.Liang, P, Tan-Ong, M, Hoffman, GS. Takayasu’s arteritis: vascular interventions and outcomes. J Rheumatol 2004; 31: 102–106.Google ScholarPubMed
61.Sharma, S, Saxena, A, Talwar, KK, Kaul, U, Mehta, SN, Rajani, M. Renal artery stenosis caused by nonspecific arteritis (Takayasu disease): Results of treatment with percutaneous transluminal angioplasty. AJR 1992; 158: 417–422.CrossRefGoogle ScholarPubMed
62.Sakai, H, Oyama, N, Kishimoto, N, Takahashi, M, Urasawa, K, Tsutsui, H. Revascularization of malignant coronary instent restenosis resulting from Takayasu’s arteritis using Sirolimus-eluting stents. Int Heart J 2006; 47: 795–801.CrossRefGoogle ScholarPubMed
63.Furukawa, Y, Tamura, T, Toma, M, et al. Sirolimus-eluting stent for instent restenosis of left main coronary artery in takayasu arteritis. Circ J 2005; 69: 752–755.CrossRefGoogle ScholarPubMed
64.Matsuura, K, Ogino, H, Kobayashi, J, et al. Surgical treatment of aortic regurgitation due to Takayasu arteritis: long-term morbidity and mortality. Circulation 2005; 112: 3707–3712.CrossRefGoogle ScholarPubMed